Product name: Allergy Research Group, Pycnogenol 100, 30 Vegetarian Capsules
Quantity: 30 Count, 0.02 kg, 7.6 x 4.1 x 4.1 cm
Categories: Allergy Research Group, Supplements, Antioxidants, Pine Bark Extract, Pycnogenol, Hypoallergenic
Original French Maritime Pine Bark Extract, Dietary Supplement, Hypoallergenic, Pycnogenol 100, Pycnogenol is the original French maritime pine bark extract, providing a unique combination of procyanidins, bioflavonoids, and phenolic acids. More than 400 published studies and review articles demonstrate its safety and efficacy.
In a randomized clinical trial, liu et al 8 found that participants with hypertension taking pine bark extract (100 Mg/d) required lower doses of nifedipine to obtain normal blood pressure but did not test the effect of pine bark extract in the absence of conventional medications. Pine bark extract is generally well tolerated, with occasional minor gastric discomfort, dizziness, nausea, and headache. In a study of 76 people with allergic asthma, pycnogenol (100 Mg/day) added to conventional corticosteroid inhalers for 6 months helped 55% of them reduce inhaler use frequency and dosage. In conclusion, our results demonstrate the anti-inflammatory and antioxidant potential of hiper containing the natural products, pbe, honey, aloe vera, and papain. Pyc also participates in the cellular antioxidant network as indicated by it’s ability to regenerate the ascorbyl radical and to protect endogenous vitamin e and glutathione from oxidative stress. After two weeks of supplementation with pycnogenol, results revealed blood flow increased in response to acetylcholine stimulation by 42 percent. In a study of 61 adhd children, pycnogenol reduced hyperactivity, improved attention, and motorics after 1 month. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders.
Allergy Research Group, Pycnogenol 100, 30 Vegetarian Capsules: Pycnogenol, Pine Bark Extract, Antioxidants, Supplements
We found that pycnogenol inhibited cell proliferation dose- and time-dependently, and the ic S of pycnogenol on hl-60, u937 and k562 cells were 150, 40 and 100 microg/ml, respectively. One study found that pycnogenol may reduce the activity of the inflammatory enzymes cox1 and cox2, similar to how nsaid drugs work. It is a natural source of several antioxidants including proanthocyanidins, which are also found in wine, grapes, apples, cocoa, tea, nuts, and some berries. In addition to main stream medical treatments, there is increasing popularity in using natural compounds for their intrinsic anti-inflammatory and antioxidant properties. No side effects due to supplementation were observed; tolerability was optimal. Here we report the scavenging activity of pycnogenol (The polyphenols containing extract of the bark from pinus maritima) against reactive oxygen and nitrogen species, and it’s effects on no metabolism in the murine macrophages cell line raw 264,7, macrophages were activated by the bacterial wall components lipopolysaccharide (Lps) and interferon (Ifn-gamma), which induces the expression of large amounts of the enzyme nitric oxide synthase (Inos). In this study, the antioxidant activity of several phytochemicals was compared using two different antioxidant assays: The oxygen radical absorbance capacity (Orac) assay, which measures the decrease in fluorescence decay caused by antioxidants, and the total oxyradical scavenging capacity (Tosc) assay, which measures the decrease in ethylene production caused by antioxidants.
Athletes can also benefit from the increase in no supported by pine bark extract, through enhanced circulation and blood flow. If using any pharmaceuticals or drugs given to you by a doctor or received with a prescription, you must consult with the doctor in question or an equally qualified health care professional prior to using any nutritional supplementation. Ic50 values for the methanol extract ranged from 11,58-16,01 mg/ml for dpph and from 9,41-15,76 mg/ml for tbars assay. A study to be published in the october edition of hypertension research reveals pycnogenol, (Pic-noj-en-all), an antioxidant plant extract from the bark of the french maritime pine tree, helps individuals by enhancing healthy nitric oxide (No) production which leads to an increase in blood flow and oxygen supply to muscles. A trial of 84 people found that both pycnogenol oral supplements and creams (0,5%) May prevent hemorrhoids from bleeding during acute attacks after 7 days. Pine bark extract is recommended to improve the health and smoothness of the skin, including damage caused by overexposure to sunlight. Furthermore, past studies 8, 15 have shown decreases in cvd risk factors when pine bark extract was tested as an adjunct to conventional pharmacologic treatment. At six months, 87 percent of those who took pycnogenol were asymptomatic, compared to almost 35 percent of controls, and had significantly better blood flow in the cochlea (A part of the inner ear that plays a key role in hearing).
Several laboratory studies have found that some of these bioflavonoids have anti-inflammatory and antioxidant properties. Supplements containing the french maritime pine bark extract pycnogenol may help protect against the effects of oxidative stress after exercise, says a new study with 20 healthy young men. Pycnogenol is officially extracted from the french maritime pine (Pinus pinaster), which grows in the southwest coast of france. The story goes that first nations tribes shared their ancestral wisdom with cartier and used the local pine tree bark as a decoction (E. The water extract of it’s bark is used treat several diseases, including some types of arthritis. (Nhs), based in hoboken, new jersey, is the north american distributor for pycnogenol (Pic-noj-en-all) brand french maritime pine bark extract on behalf of horphag research. Remember to speak with a doctor before taking pycnogenol. Many pine bark extracts on the market are not standardized and the concentration of active components and bioactivities are hard to determine. The adverse events and adverse effects questionnaire asked about symptoms commonly reported in past studies of pine bark extract, hospital and emergency department visits, new diagnoses, and changes in existing diagnoses. Pycnogenol (Pyc-nah-gen-ol) is a patented french maritime pine bark extract from horphag research. In another trial, 30 people with type 2 diabetes received a range of pycnogenol doses. Evaluation of antioxidant activity was made using dpph and tbars test.
When subjects had taken pycnogenol the relaxation of arteries was increased by 42 percent as compared to the group taking placebo tablets. More recently, pycnogenol has been subjected to more than 100 research trials. In group 3 (Experimental), after laparotomy was performed, punctate hemorrhage was induced by cecal abrasion in the cecum and each rat was intraperitoneally administered a sterile pycnogenol derivative. These constituents of pycnogenol could be detected in serum, blood cells, and synovial fluid of oa patients. There is insufficient evidence to support the use of pycnogenol for any of the uses listed below. The ophthalmoscopy and the electroretinogram (Erg) also confirmed the beneficial effects of pycnogenol. Antidiabetic effect of pycnogenol french maritime pine bark extract in patients with diabetes type ii. The water-soluble flavonoid extract was developed, trademarked, and patented by horphag research international. Pbe is extracted from the bark of the french maritime pine tree, pinus pinaster, and is commercially available as a herbal dietary supplement (Registered trade name: Pycnogenol).
Allergy Research Group Pycnogenol
We assessed whether an effect of pine bark extract might be limited to particular participant subgroups because participant baseline variables were within the normal range for many outcomes. Objective: The purpose of the present study was to evaluate and compare the effectiveness of vitamin e (E) and pycnogenol (P) in treatment of chemotherapy-related oral mucositis (Chrom) in children. Antioxidant properties of pine bark extracts have been well described in laboratory studies and are considered to be responsible for the majority of clinical effects. The pharmacology of the 19th century, with it’s extensive use of the anti-inflammatory willow bark, followed empirically the modern concept that free radicals are produced at sites of inflammation. This study shows that 200 mg of pycnogenol daily can have measurable benefits for controlling and normalizing oxidative stress, which plays a critical role for muscle recovery. While pycnogenol is thought to be safe for children, they should only take it for a few weeks at a time. Moreover, pycnogenol reduces serum levels of low-density lipoproteins (Ldl) cholesterol and increases high-density lipoproteins (Hdl) cholesterol. This supports the idea that taking pycnogenol may help control some cardiovascular risk factors, particularly in this patient population. In some studies, the extracted compounds are designated procyanidiol oligomers.
Clinical studies using pine bark extracts report no clinically important adverse events at doses of 150 mg daily; however, few studies evaluate safety as a primary outcome. Although traditional strategies such as prescription medications, dietary changes, and physical activity have proven benefits for reducing cardiovascular disease (Cvd) risk, a substantial population seeks alternative therapies, including various dietary supplements, to lower cvd risk. Some research suggests that procyanidins may have antioxidant and anti-inflammatory activity. 40 Years of research and over 400 scientific studies have confirmed what our ancestors long suspected, pycnogenol (A patented pine bark extract) has incredible health benefits. 9, 11, 12 Pine bark extract has been reported to reduce blood concentrations of endothelin, an endothelial-derived vasoconstrictor. 5 The opcs are flavonoids found in high concentration in extracts of pomegranate, grape seeds, and pine bark. Pycnogenol (Procyanidins extracted from the bark of pinus maritima aiton) is a potent free radical scavenger.
Regarding the food industry, pine bark extracts have been successfully used as antioxidants in the meat industry and have been proposed as interesting additives for the juice industry and songzhen noodles production. Systolic blood pressure change for pine bark extract group and placebo group from baseline to 6 weeks and 12 weeks. To see the full set of research information and references for pycnogenol. Reactive oxygen species (Ros) production, lipid peroxidation, reduction of antioxidant enzymes, crystalline proteolysis, and apoptosis are considered factors that contribute to pathogenesis of age-related nuclear cataract. Packer l, rimbach g, virgili f : Antioxidant activity and biologic properties of procynamidin-rich extract from pine bark, pycnogenol. Every day for two weeks young healthy men either took 180 mg pycnogenol or a placebo. It is the largest study to date of pine bark extract and cvd risk factors.
Early empirical usage of pine bark is explained through the observation that the natural pine-bark antioxidants that protect against free oxygen radicals also possess anti-inflammatory activity. As someone who is been working in the supplement industry for a very long time, i cannot advise enough only working with brands and ingredients that are deeply invested in science and production. In this study, we compared the response of human breast cancer cells (Mcf-7) and normal human mammary cells (Mcf-10) to apoptosis in the presence of pycnogenol. The ingredient is a combination of procyanidins, bioflavonoids and organic acids extracted from the bark of the maritime pine. Laboratory evidence suggests that certain specialty dietary supplements have antiinflammatory properties, though evidence in humans remains limited. Pycnogenol (Pyc), extracted from french maritime pine bark, has anti-inflammatory and antioxidant properties and can improve lipid profiles. Of the flavonoids tested, good protection in the retina was found at 10(-5) M for epigallocatechin gallate (50%) And at 50 ng/ml for pycnogenol (61%) And catechin (52%). However, increased platelet reactivity yielding aggregation 2 hours after smoking was prevented by 500 mg aspirin or 100 mg pycnogenol in 22 german heavy smokers. Pine bark extract can make a great addition to your nutritional arsenal for it’s potent antioxidant support, as well as it’s added support for blood flow, blood sugar, inflammation, immunity, brain function and skin support.
Damage caused by free radicals can be minimized by taking antioxidant supplements of key nutrients such as pine bark extract. In vitro studies suggest pine bark extract exhibits a number of beneficial effects, including inhibition of lipid accumulation in adipocytes, stimulation of lipolysis, and increased glucose uptake. Pine bark extract is rich in plant pigments called bioflavonoids. Adequate testing for such a widely used dietary supplement requires rigorous placebo-controlled clinical trials.