Product name: Bio Tech Pharmacal, D3-5 Cholecalciferol, 250 Veggie Caps
Quantity: 250 Count, 0.07 kg, 5.1 x 5.1 x 9.9 cm
Categories: Bio Tech Pharmacal Inc, Supplements, Vitamins, Vitamin D, D3 Cholecalciferol
Energy = Health, V Caps, Dietary Supplement, Vitamin D3 functions as a hormone, a chemical messenger with widespread effects in the human body. It is important for optimal bone, cardiovascular, neuromuscular, and immune health. Adequate calcium and vitamin D3 throughout life, as part of a well-balanced diet, may reduce the risk of osteoporosis. Supplementation with vitamin D may be necessary to meet daily needs, since obtaining sufficient vitamin D from natural food sources and sun exposure alone can be difficult. Research shows that vitamin D3 (cholecalciferol) is approximately 87% more potent than vitamin D2 for raising and maintaining vitamin D blood levels.
Land vertebrates required another source of vitamin d other than plants for their calcified skeletons. Local action of exogenous growth hormone and insulin-like growth factor-i on dihydroxyvitamin d production in llc-pk1 cells. Discuss supplement use with your doctor to ensure that the amount you are taking is appropriate for your needs. Exposure to sunlight for extended periods of time does not normally cause vitamin d toxicity. We liked the short list of ingredients: 2,000 Iu of vitamin d3 (As cholecalciferol, which mimics the way the body naturally processes vitamin d), soybean oil (Rich in heart-healthy polyunsaturated fats), plus gelatin, glycerin, and water for the softgel capsule. I do read the vitamin d council newsletter and it’s articles that are free to the public and not behind a pay wall. When the manufacturing method for ergocalciferol was created, binding studies of the vitamin d receptor in rats showed equipotency between ergocalciferol and cholecalciferol. (See prevention of vitamin d deficiency Below). Our take: A high-potency d3 supplement in softgel form. This result that was obtained for both adults and children reinforces the idea of a strict dependence between vitamin d function and that of gh/igf-1 axis, which is attributed to a gh and consequential igf-1 deficiency that afflicts ghd subjects with a role in determining the consensual vitamin d deficiency. The intervention was oral or i am supplements of vitamin d2 (Ergocalciferol) or d3 (Cholecalciferol), with or without concomitant calcium supplement.
Bio Tech Pharmacal, D3-5 Cholecalciferol, 250 Veggie Caps: D3 Cholecalciferol, Vitamin D, Vitamins, Supplements
Vitamin d also promotes calcium absorption, and high levels of vitamin d can cause high levels of blood calcium. The variability in both serum 25ohd concentrations and resulting hypercalcemia for a given amount of vitamin d needs also to be interpreted in light of recent developments in genetics. Vitamin d supplementation and falls: A trial sequential meta-analysis. The first one, a short-term study of 3 months that involved 113 newborns, showed no case of vitamin d excess and associated hypercalcemia or hypercalciuria. It is critical to immunocompetence and in natural and adaptive immunity, partly by influencing the activity of vitamin d metabolites. The smallest package is enough vitamin d to last for years. Before you start taking supplements, talk to your doctor about the right dosage for you. 1) Showed how the absolute increase in vitamin d status depended on the dose of supplement and also on the type of vitamin d, with vitamin d2 being less efficient than for increasing serum levels. The role of vitamin d in reducing cancer risk and progression. I also discuss a reduction in vitamin d supplementation if a patient has a blood level greater than 50 ng/ml. Vitamin d is a fat-soluble vitamin that is naturally present in very few food sources. Summary cod liver oil is the single best source of vitamin d3, fatty fish is also a good source, but you have to eat it frequently to get enough.
Outcomes of interest included: Serum/plasma 25(Oh)d, Serum/plasma pth, Differences between vitamin d 2 and d 3, and Adverse effects. Vitamin d deficiency can result in lower bone mineral density and an increased risk of reduced bone density (Osteoporosis) or bone fracture because a lack of vitamin d alters mineral metabolism in the body. Vitabright vitamin d3 has natural ingredients and i like that they are sourced responsibly and made in the uk. The most well-known symptom of vitamin d deficiency is rickets, a bone disease common in children in developing countries. Started taking vitamin d3 and the difference was night and day. In general, no good evidence supports the commonly held belief that vitamin d supplements can help prevent osteoporosis. Although this relationship seems to be significant only after supplementary vitamin d therapy, it is possible to hypothesize that in subjects with hypovitaminosis d, this should be corrected before making inquiries into the presence of igf-1 values below the norm to optimize the diagnosis of ghd, which is still complex and nonstandardized. Even seafood would have enough natural fat to help with vitamin d absorption. Adequate intake of vitamin d has shown to diminish the risk of some of the skeletal as well as nonskeletal disorders. However, according to the model derived from the meta-regression, the increase obtained by the whi trial was about half the expected average increase based on randomized trials that reported the influence of vitamin d3 supplements on serum 25-hydroxyvitamin d concentration.
Obesity, which has it’s own links to many conditions, can also reduce the amount of vitamin d in the blood because your body stores the vitamin in fat tissue, removing it from the bloodstream, where it would show up on tests. In the summer months, the use of sunscreen limits vitamin d synthesis. Decara (Cholecalciferol) for vitamin d deficiency: Decara was very helpful in improving my vit d levels. Only a few foods are a good source of vitamin d. I throughly recommend this product, especially in the winter months when sunshine (Needed by the body to convert to vitamin d3) is at a premium. You are likely to get enough vitamin d through food, and increasing your intake of vitamin d through sun exposure is not worth the added risk. I believe he also says to take k2 if you are supplementing with vitamind3, he also suggests annual testing for anyone over age 50, his research is quite amazing and i hope you get the chance to read his studies and his book. The biology and pathology of vitamin d control in bone. Vitamin d supplementation during pregnancy: Updated meta-analysis on maternal outcomes. Effect of vitamin d and calcium supplementation on cancer incidence in older women. Summary estimates from this model confirmed a significant association between the supplement dose and the change in 25-hydroxyvitamin d level. Resurrection of vitamin d deficiency and rickets. Although these two have historically been considered interchangeable and equipotent, the current body of literature strongly supports the preference of vitamin d3 (Cholecalciferol) over d2 (Ergocalciferol).
Vitamin d 2 (Ergocalciferol) and vitamin d 3 (Cholecaliferol) share a similar mechanism of action as outlined above. Single-dose vitamin d improved 25(Oh)d better than daily 800 iu vitamin d. But they do not require large amounts of vitamin d to get the benefit. The most serious complications of vitamin d deficiency are low blood calcium (Hypocalcemia), low blood phosphate (Hypophosphatemia), rickets (Softening of the bones during childhood), and osteomalacia (Softening of the bones in adults). Among these data, the pth-independent interaction between vitamin d metabolites and gh/igf-1 axis stands out. Cholecalciferol, also known as vitamin d3, is a type of vitamin d which is produced by the skin when exposed to sunlight. Vitamin d2 (Ergocalciferol) comes from fungi, and may be used in supplements. You should avoid or limit alcohol consumption while taking vitamin d3 because alcohol can decrease it’s absorption.
Bio Tech Pharmacal Inc D3 Cholecalciferol
Studies show that vitamin d may ease symptoms in people with clinical depression. Low blood calcifediol (25-Hydroxy-vitamin d) can result from avoiding the sun. Often these patients are overweight, which could be affecting their vitamin d levels. Some correlational and intervention studies note that higher serum vitamin d is associated with mildly lower blood pressure, although the evidence is somewhat conflicted and effects that have been found are rather small. Some of this variability may be explained by differences in vitamin d assay (81, 82) Or length of time between ingestion and laboratory evaluation. Awareness of the benefits of vitamin d has increased both in the medical community and the general population. Davis says testing is tricky because the vitamin goes through several steps to get to it’s active form. On the other hand, if you have been diagnosed with a serious vitamin d deficiency, your doctor will likely recommend a higher dose of vitamin d supplementation. Generally, we recommend supplementation indefinitely. Adults who have limited sun exposure are also at increased risk of vitamin d deficiency, especially if their skin is dark. In all, 154 deaths from cancer occurred in the vitamin d group versus 187 in the placebo group. My wife did the research, and found out vitamin d2 is not as well absorbed as vitamin d3, it also must be taken with a calcium supplement. The first data that relate to a correlation between ghd and hypovitaminosis d are derived from studies conducted on rats.
Among these two biochemical parameters, the authors also found a direct correlation that strengthens the idea of an igf-1/vitamin d axis with mutual influences. Vitamin d supplementation for preventing infections in children under five years of age. According to the model in table 3, if supplementation is done with vitamin d3 and if calcium supplements are not given simultaneously, the serum 25-hydroxyvitamin d concentration of these subjects should increase by 15,6 ng/ml; that is an increase of 0,78 ng/ml (1,95 Nmol/liter) per microgram of vitamin d3 supplement per day. I am not aware of any convincing randomized trial research showing that vitamin d improves arterial stiffness, but if you can share the reference here, i may be able to take a look. If you are only exposing your face and hands, you will produce much less vitamin d. Effect of race and genetics on vitamin d metabolism, bone and vascular health. Although the body can create vitamin d, a deficiency can occur for many reasons. Chemically, the various forms of vitamin d are secosteroids, i. Additional vitamins: Some d3 supplements include vitamin k, which is believed to work with d to help regulate calcium (Vitamin d helps your body absorb calcium). In other words, much of the data does not clearly support the idea that vitamin d supplementation in a patient with low vitamin d levels reduces the risk of these diseases.
Although both vitamin d 2 and d 3 undergo the same hydroxylation steps and are equipotent in treating rickets, vitamin d 2 has been found less toxic in animal studies and less efficacious in raising serum 25ohd concentration than vitamin d 3, when administered in the form of boluses. This fat soluble vitamin is stored in the liver for long periods, so intermittent use is adequate. The conversion of previtamin d 3 to vitamin d 3 in the skin is about 10 times faster than in an organic solvent.