California Gold Nutrition, French Maritime Pine Bark Extract, Oligopin, Antioxidant Polyphenol, 100 mg, 60 Veggie Caps
Product name: California Gold Nutrition, French Maritime Pine Bark Extract, Oligopin, Antioxidant Polyphenol, 100 mg, 60 Veggie Caps
Quantity: 60 Count, 0.04 kg, 4.6 x 4.6 x 8.4 cm
Categories: California Gold Nutrition CGN, Supplements, Antioxidants, Pine Bark Extract, Pycnogenol, Vegetarian, Produced In A 3rd Party Audited Cgmp Registered (Certified) Facility, Gmp Quality Assured, Produced In A Gmp Certified Facility, Gluten Free, Non Gmo, Soy Free, Certificate of Analysis
California Gold Nutrition French Maritime Pine Bark Extract Antioxidant Polyphenol, Featuring Oligopin Patented Pine Bark Extract Sourced from Les Landes Forest France, Supports Free Radical Scavenging and Anti-Inflammatory Functions, Supports Cardiovascular and Vasotonic Functions , 60 Veggie Capsules, Suitable for Vegetarians, Produced in a 3rd Party Audited cGMP Registered (Certified) Facility, Formulated to Contain: No Gluten – No GMOs – No Soy, 100% Gold Guarantee, Pine Bark (Pinus pinaster bark) contains potent polyphenol antioxidant compounds called proanthocyanidins. Antioxidants are known for their free radical scavenging functions that can help to prevent premature aging and cellular damage. Proanthocyanidins have been shown in research to have vasotonic properties and to support cardiovascular function and healthy blood flow. French Maritime Pine Bark Extract features Oligopin, a patented extract of Pine Bark sourced from Les Landes Forest France. Due to the high concentration of low mass molecular procyanidins, it is one of the most purified pine bark extracts on the market, California Gold Nutrition French Maritime Pine Bark Extract is manufactured in the USA and meets or exceeds all qualitative and quantitative Quality Control specifications, California Gold Nutrition Certificate of Analysis, Foodpharmacy Blog Blog Link: 14 Health Benefits of Pine.
In this study, we determined the effects of pycnogenol on (A) oxidative burst of macrophages, (B) oxidation of plasma low density lipoprotein (Ldl), and (C) hydroxyl radical-induced breakage of plasmid dna. The proprietary extract comes from the bark of the french maritime pine tree pinas pinaster, which grows on the coast of southwest france. A trial of 84 people found that both pycnogenol oral supplements and creams (0,5%) May prevent hemorrhoids from bleeding during acute attacks after 7 days. Since grape extract (Ge) contains oligomeric proanthocyanidins and numerous polyphenols, dietary ge supplements may exert protective effects against various diseases. This is the best antioxidant i have ever used! You may also be interested in taking an eye health supplement. Radiata bark extract effectively inhibits anaphylaxis-like reactions. 2, 3, 5 The pharmacokinetics of maritime pine bark extract constituents have been studied in human volunteers. Pine bark extract has been studied for multiple conditions including diabetic retinopathy and ulceration, tinnitus, hemorrhoids, hyperpigmentation in melasma, menopausal symptoms, motion sickness, traveler’s thrombosis, control of inflammation in lupus patients, as an adjunct for childhood asthma, and in a chewing gum for gingival bleeding and plaque. Nutritional supplements are not as well-regulated, (Or minimally regulated) as prescription drugs. Pine bark extract is recommended to improve the health and smoothness of the skin, including damage caused by overexposure to sunlight.
California Gold Nutrition, French Maritime Pine Bark Extract, Oligopin, Antioxidant Polyphenol, 100 mg, 60 Veggie Caps: Pycnogenol, Pine Bark Extract, Antioxidants, Supplements
Some research suggests that procyanidins may have antioxidant and anti-inflammatory activity. I also like the fact that pine bark is very good for your general health so everyone should take it. The popularity of natural product supplements has increased in recent years, especially those with purported anti-inflammatory and/or antioxidant effects. In vitro and animal studies using the standardized extract have indicated a multimodal action of pycnogenol, and several human studies have shown improvements in cognitive function after chronic administration. The results indicate that pycnogenol exhibits an extensive antioxidant effect in all three in vitro systems. Is available in more than 1,000 dietary supplements and multi-vitamins worldwide. Antidiabetic effect of pycnogenol french maritime pine bark extract in patients with diabetes type ii.
Safety informationas with any dietary supplement, consult your healthcare practitioner before using this or any product if you are pregnant, nursing, trying to conceive, taking medication or have a medical condition. In a randomized clinical trial, liu et al 8 found that participants with hypertension taking pine bark extract (100 Mg/d) required lower doses of nifedipine to obtain normal blood pressure but did not test the effect of pine bark extract in the absence of conventional medications. There were no subgroups for whom intake of pine bark extract affected cardiovascular disease risk factors. Most subgroups reviewed suggest an overall beneficial effect on microvascular function, particularly grape-derived products, cocoa, tea, pine bark and rutaceae aurantiae. Investigators and all study staff were blinded to treatment assignment until all study results were collected, at which time the study sponsor revealed which tablet, a or b, contained pine bark extract. Nhs has the exclusive rights to market and sell pycnogenol in north america and benefits from more than 35 years of scientific research assuring the safety and efficacy of pycnogenol as a dietary supplement. Studies have shown that taking 30 – 150 mg pycnogenol daily helps support the mobility and flexibility of joints and reduces aches and pains. (Nhs), based in hoboken, new jersey, is the north american distributor for pycnogenol (Pic-noj-en-all) brand french maritime pine bark extract on behalf of horphag research.
All five studies reported subjective improvements in cvi-related symptoms in the pycnogenol treatment groups. The evidence supporting supplements made from french pine bark is not convincing. This is the first report about positive cellular effects of a dietary supplement on key catabolic and inflammatory markers in patients with severe oa. Approximately 60% of patients treated with pycnogenol(R) experienced a complete disappearance of edema (The most rapidly disappearing symptom) and pain at the end of the treatment, while almost all the patients reported a reduction in leg heaviness which disappeared in approximately 33% of patients. Devaraj s, vega-lopez s, kaul n, schonlau f, rohdewald p, jialal i : Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. A trial of 39 people with hay fever found that pycnogenol may reduce nose and eye symptoms. M1 also displays structural features that allow oxidation under formation of an electrophilic benzoquinone that would be preferentially attacked at c4 by the nucleophilic thiol moiety of glutathione. Protection from inflammation, immunosuppression and carcinogenesis induced by uv radiation in mice by topical pycnogenol. I have not changed my diet, taken any new meds or anything like that so it has to be the pine bark supplement. In rodent studies, pine bark extract showed antioxidant effects and improved insulin resistance and hyperglycemia.
The purpose of the present study was to examine whether 14 days of supplementation with maritime pine extract leading up to and following an exercise test would increase performance and reduce biomarkers associated with muscle damage, inflammation, and oxidative stress. Of the extract, and advocates say the antioxidants fight oxidative stress involved in disease development. A study of 146 people suffering from a common cold found supplementing with pycnogenol was able to reduce the duration (I. In addition, pycnogenol can help maintain your skin elasticity and hydration and slow the aging process. In group 3 (Experimental), after laparotomy was performed, punctate hemorrhage was induced by cecal abrasion in the cecum and each rat was intraperitoneally administered a sterile pycnogenol derivative. Clinical studies using pine bark extracts report no clinically important adverse events at doses of 150 mg daily; however, few studies evaluate safety as a primary outcome. In total, 40 patients with diabetes, atherosclerosis and other vascular diseases involving the retina were enrolled; 30 of them were treated with pycnogenol and 10 with placebo.
California Gold Nutrition CGN Pycnogenol
Doses of pine bark extract 60 to 300 mg daily have been studied in clinical trials, most commonly at 150 mg/day in 3 divided doses. For that reason, you should be careful taking pine bark if you have hypertension or diabetes. While no specific incidents have been reported, as an immunostimulant, pycnogenol may increase symptoms of immune system disorders such as multiple sclerosis, lupus, and rheumatoid arthritis. In conclusion, our results demonstrate the anti-inflammatory and antioxidant potential of hiper containing the natural products, pbe, honey, aloe vera, and papain. 5,0 Out of 5 stars i found that this supplement was recommended by the american uveitis society that could help control. Thus, smoking-induced enhanced platelet aggregation was inhibited by 500 mg aspirin as well as by a lower range of 100-125 mg pycnogenol. Herein, we look at the most recent uses of pine bark extracts in the food industry and for biomedical purposes. To investigate possible mechanisms involved in pycnogenol’s suppression of peroxide release, confluent monolayers of j774 cells were incubated with pycnogenol for 18 h, washed, resuspended in phosphate buffered saline, and sonicated to obtain a cell lysate. This supports the idea that taking pycnogenol may help control some cardiovascular risk factors, particularly in this patient population.
Statements regarding dietary supplements have not been evaluated by the fda and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Participants were queried about their use of dietary supplements and medications at screening and were asked to report any changes. Pine bark has been used as a food source in emergencies. In one clinical trial of 156 osteoarthritis patients, pycnogenol reduced pain, stiffness, swelling, and improved joint function after 3 months. We previously reported that pycnogenol prevents vascular endothelial cells from injury induced by an organic oxidant t-butyl hydroperoxide. Reduction of cardiovascular risk factors in subjects with type 2 diabetes by pycnogenol supplementation. Research shows that pine bark extract is capable of reducing pro-inflammatory cytokines il-1 and il-6, responsible for many of the adverse effects of chronic inflammation. Start receiving pine bark extract’s benefits now!
Pycnogenol may increase the risk of bleeding, so it should be avoided by those with bleeding disorders, people taking blood thinning medication or supplements, or in the weeks before surgery. This metabolite is no constituent of the extract, but is generated in vivo from the procyanidins Catechin units through multiple step reactions. These results also lead me to determine that pycnogenol will be a useful natural alternative therapy in various diseases in which oxidative stress is involved in the pathogenesis. Is available in more than 1,000 dietary supplements, multi-vitamins and health products worldwide. Here we report the scavenging activity of pycnogenol (The polyphenols containing extract of the bark from pinus maritima) against reactive oxygen and nitrogen species, and it’s effects on no metabolism in the murine macrophages cell line raw 264,7, macrophages were activated by the bacterial wall components lipopolysaccharide (Lps) and interferon (Ifn-gamma), which induces the expression of large amounts of the enzyme nitric oxide synthase (Inos). A study of 47 women with painful menstrual cramps who were given 30 mg pycnogenol twice a day, showed subjects had fewer days of menstrual pain when taking the product. A recent study showed that pycnogenol can offer protection from the free radicals that come from the harmful rays of the sun (Photoprotection) and may also reduce hyperpigmentation of the skin, improve the skin barrier function and extracellular matrix homeostasis (The maintenance of the structure of cells and soft tissues).
A double blind, placebo-controlled study of 77 diabetic patients taking their prescription medications, along with 100mg of supplemental pycnogenol, found greater improvement in blood sugar control and cardiovascular health when pine bark extract was combined with diabetic medications. The glutathione (Gsh) redox cycle and antioxidant enzymes-superoxide dismutase (Sod) and catalase (Cat)-play an important role in scavenging ros and preventing cell injury. Although the type of rampant inflammation during a flare far-exceeds the ability of pycnogenol, it has shown some efficacy for patients in remission phases of their disease, where symptoms tend to be driven by lower-level, chronic inflammation. 1 A majority of the studies reviewed in this article focus on it’s antioxidant, anti-inflammatory, and vasodilation properties. Pycnogenol (Procyanidins extracted from pinus maritima) has been reputed as a potent free-radical scavenger and an antioxidant phytochemical. Confusion previously arose when grape seed extract was marketed as containing pycnogenol. Pycnogenol is another name for the extract of french maritime pine bark. Radiata bark on compound 48/80-induced or antidinitrophenyl (Dnp) immunoglobulin e (Ige)-mediated anaphylaxis-like reactions in vivo. The plethora of research available regarding pycnogenol suggests it has a promising future, particularly as a preventative and adjunct treatment for cvd, diabetes, and cvi.
By becoming an examine plus member, you will have access to all of the latest nutrition research on over 300 supplements across over 500 different health goals, outcomes, conditions, and more. If viva’s pycnogenol is doing this much good on the outside where i can see the improvement, how much good is it doing on the inside? How do one actually find the words to describe pine bark extract have been taken it for almost 25 years and still am taking it, l will end up writing an essay. Stafford said the researchers felt these were the types of people who would be more likely to seek out dietary supplements as an alternative therapy.