Product name: California Gold Nutrition, Vitamin K2 (as MK-4, MK-6, MK-7, MK-9), 120 mcg, 60 Veggie Capsules
Quantity: 60 Count, 0.05 kg, 8.4 x 4.6 x 4.6 cm
Categories: California Gold Nutrition CGN, Supplements, Vitamins, Vitamin K, Vegetarian, Vegan, Gluten Free, Non Gmo, Soy Free, Produced In A 3rd Party Audited Cgmp Registered (Certified) Facility, Gmp Quality Assured, Produced In A Gmp Certified Facility, Certificate of Analysis
California Gold Nutrition Full Spectrum Vitamin K2, Blend of MK-7, MK-4, MK-6 and MK-9, Featuring Menaquinone-7 and MenaQ7, Supports Bone and Cardiovascular Health, Suitable for Vegetarians and Vegans, Formulated to Contain: No Gluten, No GMOs, No Soy, Produced in a 3rd Party Audited cGMP Registered (Certified) Facility, Vitamin K is the generic term for a family of fat soluble essential vitamin compounds that play an important role in bone and cardiovascular health. Vitamin K2 refers a group of compounds called menaquinones that are part of the Vitamin K family and are the most well recognized for their health promoting value and bioavailability, California Gold Nutrition Full Spectrum Vitamin K2 contains a blend of menaquinone compounds: MK-7, MK-4, MK-6 and MK-9. Each MK compound is produced from a fermentation process in which the end result is soy free. MenaQ7 is sourced from naturally fermented chickpea protein that research has shown to be long lasting, bioactive and bioavailable, Foodpharmacy Blog Blog: What are the Health Benefits of Vitamin K2? iTested, Quality Confirmed: Certificate of Analysis.
Certain hard and soft cheeses are also good sources of vitamin k2, in the form of mk-8 and mk-9, additionally, a recent study discovered several pork products contain vitamin k2 as mk-10 and mk-11. When data from a large study of more than 16,000 women was analyzed, the results showed subjects reduced the risk of developing heart disease by 9% for every 10 micrograms of vitamin k2 taken. Reported no correlation between responses in a food frequency questionnaire and plasma phylloquinone. All but 2 trials used menaquinone-4, with the remainder using phytonadione supplements. It uses soybean oil to dissolve the vitamin k2, instead of the healthier but more expensive olive oil or coconut oil used by other supplements, and purists will not like the use of artificial coloring agents either. The binding of calcium ions in this way very often triggers the function or binding of gla-protein enzymes, such as the so-called vitamin k-dependent clotting factors discussed below. Read for yourself on how important vitamin k is for your health! Compared to the other fat-soluble vitamins, very small amounts of vitamin k circulate in the blood. Plasma vitamin k1 in mothers and their newborn babies. Because a synthetic form of vitamin k, vitamin k 3 (Menadione), may be toxic by interfering with the function of glutathione, it is no longer used to treat vitamin k deficiency.
California Gold Nutrition, Vitamin K2 (as MK-4, MK-6, MK-7, MK-9), 120 mcg, 60 Veggie Capsules: Vitamin K, Vitamins, Supplements
Moreover, higher doses of calcium from supplements than calcium obtained from dietary intake might promote cardiovascular calcification. Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat. Despite positive outcomes of calcium supplementation, a risk for cardiovascular risk events may exist in specific population. Other populations with an increased prevalence of vitamin k deficiency include those who suffer from liver damage or disease (E. The sudden popolarity of vitamin d3 and k2 supplement combinations has made finding the perfect of these combination products a difficult task. Furthermore, in individuals with inadequate calcium intake, the supplementation plan seems to be beneficial in reducing fragility fractures especially in osteoporotic women (86, 107). Both vitamins k1 and k2 can partake in the activation of vkdp; however, long-chain menaquinones, which are more hydrophobic, have a higher bioavailability and longer half-life and thus bioactivity (154, 155). A growing body of evidence is also documenting the interaction between vitamins d and k in animal models. A safe strategy for addition of vitamins and minerals to foods. This is because vitamin k is a fat-soluble vitamin.
Though this needs to be studied in more detail, current research on vitamin k2 and health is promising. It has several subtypes called menaquinones (Mks) that are named by the length of their side chain. Some cholesterol-lowering medications can also interfere with the body’s ability to absorb vitamin k. The ageing population – especially in major markets like europe, japan, china and the us – is also having an impact on supplement sales, with an increase in osteoporosis resulting in more interest in bone health. In osteoporotic patients, vitamin k2 resulted in elevated levels of coc and prevented fractures when compared with placebo-treated osteoporotic patients. Many studies have confirmed the link between the levels of these vitamins and lower incidences of cancer. The science certainly shows a greater need for mk-4 over mk-7, i think you need mk-4 more than mk-7, i take both and eat cheese for the longer mks like mk-8 and 9 that are not available as supplements. The recommended dietary allowance (Rda) for vitamin k is based on the requirements for blood clotting.
In the last few years, physicians have reported a rise in late-onset cases of vkdb due to an increasing trend of parental omission or refusal of newborn vitamin k prophylaxis. Both trials reported the restoration of serum vitamin k and undercarboxylated osteocalcin levels to the normal range after one month of daily supplementation with 1 mg of vitamin k. In one trial (14 Children aged 8 to 18 years old) for one month half of the participants were given oral vitamin k supplements at a dose of 1 mg/day and the other half were given 5 mg/day. Further investigation may seek to evaluate whether phylloquinone supplementation could improve skeletal health in subjects at high-risk for vitamin k inadequacy (E. I had ordered country life natural vitamin a and d3 last week along with the thorne mk4 and it was delivered today! Infants whose mothers are on anticonvulsant medication to prevent seizures are also at risk for vitamin k deficiency. Vitamin k, specifically the vitamin k2 form, plays a significant role in the maintenance of healthy bones, and we are only beginning to appreciate the full extent of it’s impact on human health. In the presence of vitamin k both proteins are carboxylated (Cmgp and coc) preventing calcification of vsmc and promoting mineralization of osteoblasts.
Also my b12 levels were sky high and i do not supplement with b12, she prescribed lithium orate at 5mg to balance b12, read dr. Perhaps because of it’s limited ability to store vitamin k, the body recycles it through a process called the vitamin k-epoxide cycle (Figure 2). The factors involved in the regulation of calcification are being studied, including matrix gla protein (Mgp) and vitamin k2 or menaquinones. In this review we provide the latest insights of the calcium paradox and the potential of using vitamin k to support both bone and vascular health. A three-year, double-blind, controlled trial investigated the potential effect of vitamin k on the progression of coronary calcification in 401 older, community-dwelling adults (Ages, 60-80 years) free of cvd at baseline. The structure of phylloquinone, vitamin k 1, is marked by the presence of a phytyl group. An excellent selection of k2 supplements can be found on amazon. However, because green leafy vegetables are the primary dietary source of phylloquinone and because they are usually part of a balanced diet, high phylloquinone consumption may be just an indicator of healthy eating habits which may, rather than phylloquinone itself, account for all or part of the association reported in observational studies. I want to be clear, just because these are the supplements that my doctor approved of, it might not be the best for you! Like b vitamins, vitamin k is a family of vitamins and k1 and k2 are the most important to know about.
California Gold Nutrition CGN Vitamin K
Worldwide, a large group of people is prescribed to a supplemental regime of both vitamin d and calcium. Identification and purification to near homogeneity of the vitamin k-dependent carboxylase. This supplement is gluten free, vegetarian, and kosher. Yet, the investigators found no association between dietary phylloquinone intake and bone mineral density (Bmd) in the framingham subjects. The amount of vitamin k2 present in animal-based products depends mainly of the quality and type of food fed to the animals while they are young and developing. Average diets are usually not lacking in vitamin k, and primary deficiency is rare in healthy adults. For example, cooked spinach has a 5% bioavailability of phylloquinone, however, fat added to it increases bioavailability to 13% due to the increased solubility of vitamin k in fat. These limited studies indicate that joint supplementation might be beneficial for cardiovascular health. Carboxylation is the chemical modification of proteins triggered by the presence of vitamin k. Foods rich in vitamin k2 are very rare in a western diet.
In people with cystic fibrosis, the pancreas often does not produce enough enzymes to allow the body to absorb digested food properly and this may also be linked to deficiencies of fat-soluble vitamins like vitamin k. For example, the incidence of vertebral fractures was inversely correlated with lumbar bmd and plasma phylloquinone in a four-year prospective study that included 379 japanese women ages 30-88 years. Western diet does not provide sufficient vitamin k to activate all oc and mgp that is produced (21, 22). G, rifampin and isoniazid) to pregnant or breast-feeding women may place the newborn at increased risk of vitamin k deficiency. When both foods and supplements are considered, the average daily vitamin k intake increases to 164 mcg for women and 182 mcg for men. It explains why menaquinones may have a relatively large impact on extra hepatic vit k status than generally assumed, and that mk9 may form a more constant source of vitamin k. It has been suggested that increased circulating ucoc/oc ratio could reflect a poor overall nutritional status that would include vitamin d inadequacy, which would explain the above-mentioned observations. With such low effects it would be challenging to implement calcium supplementation into standard treatment for reduction of fracture risk in the healthy elderly population.
I have read above website link, they high recommended to take vitamin k2 mk7 form not mk4 because mk4 form is synthetic form but you said mk4 is better than mk7, may you explain why? Controversies concerning vitamin k and the newborn. Although supplementation with phylloquinone decreased ucoc levels in all five studies, only one study reported an effect of supplemental phylloquinone on bmd. Supplements of vitamin k1 and k2 may help reduce the risk of diabetes by improving insulin sensitivity and glucose metabolism, says a new review of the scientific literature. In addition, certain medications can have an adverse effect on vitamin k levels. Vitamin k is a group of fat-soluble vitamins that share similar chemical structures. In western populations, vitamin k2 deficiency seems to be common. Molecular basis of vitamin k-dependent gamma-carboxylation. You may have thinner blood, but you may also increase arterial calcification with the medically-induced vitamin k deficiency. Use of vitamin k1 in pregnancy: Effect of serum bilirubin and plasma prothrombin in the newborn. Because vitamin d absorption can be impacted by diet, lifestyle, age, health, surgery, and genetic variation, dr. If you doubt this, ask your doctor how many classes he had on vitamins and holistic treatment while in medical school, the answer should be near zero.
Nearly 50 years later, we continue to innovate science-backed vitamins and supplements, delivering wellness solutions that help people live simply healthier together, and find vitality at any age. Most people do not get enough of either of these vitamins, so those doing the recommending are well-intentioned. Quickly and easy look up evidence on over 400 supplements across over 500 different health goals, outcomes, conditions, and more. An additive effect was noticeable for decreased percentage of uncarboxylated osteocalcin, which indicates an improved vitamin k status in the treatment group.