Product name: Carlson Labs, Lycopene, 15 mg, 180 Soft Gels
Quantity: 180 Count, 0.09 kg, 5.1 x 5.1 x 10.4 cm
Categories: Carlson Labs, Supplements, Antioxidants, Lycopene, FDA Regulated Facility, Gluten Free, No Artificial Preservatives
Tomato-Free, Dietary Supplement, Prostate Health, Cardiovascular Support, Antioxidant, Potency and Quality Guaranteed, An FDA Regulated Facility, Gluten Free, No Artificial Preservatives, Carson – Providing the highest quality nutritional supplements since 1965, Lycopene is a powerful antioxidant carotenoid that promotes prostate health, supports healthy cardiovascular function, and helps protect against free radical damage. Carlson Lycopene is tomato-free.
In general, lipid-soluble antioxidants protect cell membranes from lipid peroxidation, whereas water-soluble antioxidant molecules react with oxidants in the hydrophilic cell cytosol and blood plasma. Studies have shown that antioxidant supplements may help prevent the deterioration of cognition. In a chemoprevention study, 59 transgenic adenocarcinoma of the mouse prostate (Tramp) mice were fed diets supplemented with tomato paste or lycopene beadlets (Both preparations contained 28 mg lycopene/kg chow). Whilst we accept the limitations of a post-hoc correlation analysis combining data from 2 non-stratified arms (Namely hv and cvd patients), we were able to demonstrate a correlation between changes in serum lycopene concentrations and changes in endothelium dependent vasodilatation, irrespective of whether this increase in lycopene was due to changes in dietary intake or treatment allocation. Carotenoids in human buccal mucosa cells after 4 wk of supplementation with tomato juice or lycopene supplements. It seems to be one of the highest concentrations of lycopene and a good price for the two tubs. A major question, however, is whether delivering lycopene through a supplement source is as effective as or more effective than consuming lycopene through whole food sources, specifically the tomato, which is the richest source of lycopene in the western diet. The combination effect of the selenium and vitamin e could be synergistic, as was demonstrated in in vitro experiments where the 2 supplements together achieved greater cell growth inhibition than either alone.
Carlson Labs, Lycopene, 15 mg, 180 Soft Gels: Lycopene, Antioxidants, Supplements
Nonetheless, there continues to be interest by consumers and a booming dietary supplement industry built on sales of naturally and synthetically derived individual nutrients and dietary components, of which lycopene and tomatoes are 1 example. Plants and photosynthetic bacteria naturally produce all- trans lycopene. The recommended dietary allowance (Rda) for men is 900 mcg and it is estimated that approximately 3% of men are taking this vitamin as a supplements. The bioavailability of lycopene varies according to the preparation of tomatoes (Puree, ketchup etc), as well as it’s origin, size, shape, and the manner in which it is consumed (Very bioavailable in the presence of oil, for instance). Based on extrapolations from the epidemiological literature, to match the lycopene intake among the people with the lowest risk for cardiovascular disease and prostate cancer, you should strive for at least 10 mg of lycopene per day, and a higher intake of 15-30 mg per day is probably better. Alpha-lipoic acid as a biological antioxidant. A number of clinical studies have been conducted investigating lycopene as a chemopreventive agent and as a potential treatment for prostate cancer. Studies on lycopene supplementation for breast cancer prevention are lacking.
No association between vitamin e supplements and prostate cancer risk was found. Thus, zinc supplementation could promote the development of prostate cancer. In addition, epidemiological studies have determined that natural lycopene may be particularly important for the support of prostate health, as well as for the health of the digestive tract. 1,2 Unfortunately, the human body is unable to produce lycopene and therefore must obtain this molecule from natural sources containing dietary carotenoids. Prostate cancer cells were treated with three different pectins; cp, pectasol (Pes, a dietary supplement containing mcp), and fractionated pectin powder (Fpp). Although vitamin supplements are generally regarded as safe, the studies included in this review did not provide good evidence as to safety as they were generally too small. Polyphenols are chemicals that act as powerful antioxidants. Unlike other fruits and vegetables, where nutritional content such as vitamin c is diminished upon cooking, processing of tomatoes increases the concentration of bioavailable lycopene. There is evidence that dietary fat may help increase the absorption of carotenoids, including lycopene.
Most studies have examined the association of lycopene intake with the risk of all prostate cancers and have not separately considered indolent versus aggressive disease. Fractionate analysis of the phytochemical composition and antioxidant activities in advanced breeding lines of high-lycopene tomatoes. No prospective controlled clinical study of lycopene supplementation has been performed to date. In a placebo-controlled, double-blind, randomized study, 199 men with localized prostate cancer were randomly assigned to either a food supplement, pomi-t, or placebo (2:1) For 6 months. So, again, we are unable to comment whether different doses of the supplement to the ones used here may lead to the same results. A systematic review of the evidence on harms of vitamin supplements is needed. The trial was stopped early when researchers saw a significant increase in lung cancer among those taking the supplement compared to those taking the placebo. Compliance with the intervention was good and similar in both treatment arms, with median compliance of 97,6% and 94,3% in the placebo and lactolycopene arms, respectively (Table 1).
Duration of treatment, dose and bioavailability of lycopene, and vascular endpoint were also different in the studies published on this topic and might have influenced obtained results. No one would deny that vitamin c is vital to a healthy lifestyle, as are all antioxidants, but unless you are following doctor’s orders, these supplements are rarely going to be the answer for a longer life when a healthy diet is also an option. The clinical research on using lycopene for systemic inflammation in people who are overweight or obese uses a high lycopene diet in conjunction with supplementation, so you may need to up the standard dosage. A greater decrease in serum psa levels was observed in men treated with lycopene supplements, compared with those who did not take the supplementation. The ability of antioxidants to combat free radicals strengthens the immune system to identify and fight toxins. When the effects of tomato extract supplementation were studied in 50 moderately hypertensive individuals, supplementation for 6 weeks was associated with reduced systolic and diastolic blood pressure (Sbp and dbp, respectively) and increased serum lycopene levels. Tomato consumption does increase lycopene concentrations in the breast milk and plasma of lactating women. The daily telegraph said that the new product contains lycopene, a natural compound found in tomatoes that is a powerful antioxidant.
Carlson Labs Lycopene
While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people. I have been taking lycopene for a number of years, following recommendations by a doctor on television that it was good for prostate health. Considering the mentioned anti-inflammatory mechanisms (Figure 3), including decrease of adhesion molecules, pro-inflammatory cytokines, inhibition of leukocyte migration and genes involved in inflammation, impaired monocyte-endothelium interaction, t lymphocytes activation and synthesis of age and rage and downregulation of cyclooxygenase 2, lycopene can be useful in the therapy for vascular inflammatory disorders. It is reported to have powerful antioxidant properties which prevent and reduce oxidative stress. Animal and epidemiological studies have suggested there may be an inverse relationship between selenium supplementation and cancer risk. Furthermore, the molecular mechanisms behind the actions of lycopene on human rpe cells, and the potential beneficial effects of lycopene in the prevention and treatment of age-related macular degeneration and proliferative vitreoretinopathy, are discussed. Reported reduced systolic bp at a similar dose (15 Mg/d lycopene) in healthy participants, suggesting that lycopene may also have a role in reducing or maintaining bp within the normal range.
More research is needed to determine the effects of lycopene alone. Since tomatoes also contain other nutrients, such as vitamin c and potassium, the potential benefits of lycopene alone are still unclear. Lycopene is one of the most biologically active plant-derived compounds, and tomatoes and tomato-based foods are the richest sources of lycopene in the american diet. In vitro experiments support the conclusion that increased bioavailability of lycopene cis-isomers is at least partially due to increased micellarization and increased uptake by the enterocyte compared to all- trans lycopene. Our goal was to determine whether there was compelling evidence in favor of lycopene supplementation or tomato intake to reduce cvd risk. The other study, 37 an rct of lycopene supplementation for 2 years in addition to orchidectomy, was also small (54 Patients), and neither rct achieved a jadad score of 3 or higher. They are white, not red, not sure why they are not red but i take the manufacturers at their word and swallow them, expecting all the benefits of this supplement.
49 Plasma ldl cholesterol concentrations were reduced by 14% in 6 men consuming dietary supplements of lycopene 60 mg/day for a 3-month period. These synergistic effects hamper assessment of quantitative and qualitative effects of lycopene as a dietary factor. Caution is advised in people taking herbs or supplements that lower blood pressure. Most of the time, if you eat a balanced diet, supplements should not be needed. The dietary/tomato lycopene intervention produced intermediate results. More information is needed on the potential effects of lycopene alone. 2, Barqawi a, gamito e, o’donnell c, crawford ed: Herbal and vitamin supplement use in a prostate cancer screening population.
However, adding mevalonate prevented the growth-inhibitory effects of lycopene, indicating that the mevalonate pathway may be important to the anticancer activity of lycopene. Although not all studies have found that lycopene confers a protective effect against prostate cancer, 36 data from a variety of case-control and large prospective studies focusing on dietary assessment show a beneficial effect, especially against advanced prostate cancer. Therefore, studies using these assay methodologies for aox status to illustrate the associated health effects of tomato intake or lycopene supplementation should be interpreted with caution. It has been shown that this strong antioxidant blocks free radicals that can damage cells. Tomato consumption and plasma lycopene concentration in people aged 65 y and over in a british national survey. That left another 10 studies that found many patients to be in a measurably worse state after being administered antioxidants than before, including an increased incidence of diseases such as lung and breast cancer. It is possible that antioxidant vitamins may help to protect the macula against this deterioration and loss of vision.
The national institutes of health-american association of retired persons (Nih-aarp) diet and health study was initiated to examine whether supplemental vitamin e and dietary tocopherol intakes may prevent prostate cancer. Once absorbed, lycopene is distributed to tissues around the body, but not uniformly. Most of the studies considered only tomatoes and tomato products as lycopene source. Calcium, the most abundant mineral in the body, is found in some foods, added to others, available as a dietary supplement, and present in some medicines (Such as antacids). There are cases of intolerance or allergic reaction to dietary lycopene, which may cause diarrhea, nausea, stomach pain or cramps, gas, and loss of appetite. Compared with placebo, selenium supplementation had no effect on prostate cancer incidence or psa velocity. These data are consistent with previous studies, suggesting that lycopene can prevent malignant transformation in human prostatic epithelial cells at the stages of cancer initiation, promotion, and/or progression. But randomized controlled trials of patients with advanced cancer did not find significant benefit of supplementation over placebo. Comparative multiple dose plasma kinetics of lycopene administered in tomato juice, tomato soup or lycopene tablets. Among men with baseline psa values of less than or equal to 4 ng/ml, the results showed a significant 65% reduction in prostate cancer incidence with selenium supplementation.
One study examined vitamin and supplement use in men with a family history of prostate cancer.