Product name: Carlson Labs, Vitamin K2 MK-7 (Menaquinone-7), 45 mcg, 180 Soft Gels
Quantity: 180 Count, 0.14 kg, 5.6 x 5.6 x 11.2 cm
Categories: Carlson Labs, Supplements, Vitamins, Vitamin K, Gluten Free, No Artificial Preservatives, FDA Regulated Facility
Dietary Supplement, Bone Support, Cardiovascular Function, Calcium Bioavailability, Gluten-Free, No Artificial Preservatives, Potency and Quality Guaranteed, An FDA Regulated Facility, Vitamin K2 as MK-7 (menaquinone-7), derived from chickpeas, plays a role in several important functions beyond supporting healthy blood clotting, including promoting bone and cardiovascular system health. Vitamin K helps direct calcium to where our body needs it most, and MK-7 is the most bioactive form.
The situation with vitamin k2 is somewhat similar. Of the 10 menaquinone forms, mk-4 (With a shorter side chain) and mk-7 (With a longer side chain) are the most important to bone health. In this article, we discuss vitamin k-2, it’s functions, and how it differs from k-1, we also describe dietary sources, health benefits, the recommended daily intake, deficiency symptoms, and supplements. I just got the innovix labs vitamin k2 supplement and i am wondering if my wife who has just got pregnant should take this supplement as well as it has a much higher dosage than the recommended. The discovery of these vitamin k-dependent proteins is very significant, as it highlights how widely disbursed they are in many tissues of the body. You should choose a supplement that provides the daily recommended intake (Rdi) of vitamin d3 and k3, the majority of the products on the market offer much higher amounts of colecalciferol and menaquinone than the rdi. Though your body is quite capable of absorbing vitamin k in any of it’s forms, vitamin k that is found in vegetables is thought to be absorbed less efficiently than vitamin k2 from a supplement. These limited studies indicate that joint supplementation might be beneficial for cardiovascular health. Metabolism and cell biology of vitamin k. Adults need approximately 0,001mg a day of vitamin k for each kilogram of their body weight, according to the nhs. Meaning this little-known vitamin is a powerhouse when it comes to healthy bones, and a healthy heart.
Carlson Labs, Vitamin K2 MK-7 (Menaquinone-7), 45 mcg, 180 Soft Gels: Vitamin K, Vitamins, Supplements
However, it is not clear whether this measure can be used to quantitatively assess vitamin k status. The administration of vitamin d and/or calcium along with vitamin k could partly explain why some studies have found that vitamin k supplementation improves bone health while others have not. Overall, intervention trials have been inconclusive regarding the role of supplemental vitamin k in further reducing bone loss in otherwise calcium- and vitamin d-replete adults. But you may not know that it’s name actually refers to a group of several vitamins that provide health benefits far beyond helping your blood clot. Additional information on the interaction between warfarin and vitamin k is available from the national institutes of health clinical center. Although allergic reaction from supplementation is possible, no known toxicity is associated with high doses of the phylloquinone (Vitamin k 1) or menaquinone (Vitamin k 2) forms of vitamin k, so no tolerable upper intake level (Ul) has been set. However, these products must be used for at least 6 months to resolve an acute case of hypovitaminosis. The advantage of lowering phosphate concentrations if thus offset by aggravation vitamin k deficiency. Dietary induced subclinical vitamin k deficiency in normal human subjects.
Koncentrated k provides doses of three different types of vitamin k at levels high enough to have an effect on any disease process that may have begun, and enough to forestall any diseases that may begin as a result of vitamin k deficiency. Without vitamin k, the proteins are unable to move the calcium around appropriately, and carboxylation of these proteins is incomplete. However, studies involving supplements containing k1 or the mk-4 form of k2 tend to use very high doses (E. These findings have led some experts to suggest the use of an initial phylloquinone dose of 0,3 mg/kg for infants with birth weights of less than 1,000 g (2 Lbs, 3 oz), and an initial phylloquinone dose of 0,5 mg would probably prevent hemorrhagic disease in newborns. And quite a few other sites that say for pregnant women to steer clear of extra vitamin a. Menadione, which is sometimes called vitamin k3, is another synthetic form of vitamin k. I want to be clear, just because these are the supplements that my doctor approved of, it might not be the best for you! Vitamin k is a group of fat-soluble vitamins that share similar chemical structures. You should take an adequate amount of vitamin k2 to ensure that the vitamin d3 functions properly, and also to prevent arterial hardening which results from the improper depositing of calcium. Multiple scientific studies on postmenopausal women suggest that combined d3 / k2 supplements can improve bone density, possibly reducing the risk of fractures as you get older. Foods rich in vitamin k2 are very rare in a western diet.
The vitamin is dissolved in a mix of medium chain triglycerides and soybean oil, so absorption is likely to be good. Yes, many medical professionals think your talking about potassium (Chemical element k) when you mention vitamin k2, while you may have figured out some of these things by yourself, i strongly recommend that you track down a licensed integrative medicine md near you. Consequently, severe liver disease results in lower blood levels of vitamin k-dependent clotting factors and an increased risk for uncontrolled bleeding (Hemorrhage). When i supplement, i take my a, d3, k2, and e complex together with a meal. I wanted to use vitamin k2, but i am on coumadin/warfarin for heart problems caused by a heart attack i had 16 years ago. The benefits of supplementing with k2 may be enhanced even further when combined with a vitamin d supplement, as these two vitamins have synergistic effects. In addition, menaquinone intake was found to be inversely associated with aortic calcification, a major risk factor for cvd. A: You can find vitamin k2 specifically in fermented foods, like cheese, miso, tempeh, or natto. Vitamins d and k are both fat-soluble vitamins and play a central role in calcium metabolism. However, higher vitamin k intakes were not associated with lower cvd mortality in a prospective study that followed 7,216 older adults at risk for developing cvd. Pulse wave velocity was higher with the number of g-allele polymorphisms and highest in the top quartile of dp-ucmgp for the gg vitamin d receptor genotype.
The identification of gla as the result of vitamin k action has made it possible to search for vitamin k-dependent proteins on the basis of their amino acid structure: Each protein in which gamma-carboxyglutamate, generally referred to as gla, is found contains the fingerprint of vitamin k action during it’s biosynthesis. This study measured pivka-ii (Protein induced by vitamin k absence) and prothrombin time in intensive care patients and correlated vitamin k status with mortality. A: Vitamin k2 in supplements is going to be one of two forms: Mk-4 or mk-7, the mk-4 form is extracted from specific bacteria that produce this form of vitamin k2, while the mk-7 form is isolated from natto, a fermented soy product. A salad dressed with olive oil, for example, will help the supplement to assimilate more readily. K complete provides vitamin k1, k2 as mk-4, and k2 as mk-7 in a single soft gel. In summary, vitamin k may improve insulin sensitivity in men with diabetes. The realm of vitamin k dependent proteins: Shifting from coagulation toward calcification. The authors also suggest that the vitamin k-dependent protein osteocalcin (Oc) is important in the regulation of glucose metabolism. By increasing intakes of vitamin k2 in the general population, we may reduce worldwide healthcare spending on osteoporosis and offer substantial benefits to individuals in terms of bone and cardiovascular health.
Carlson Labs Vitamin K
There is some intriguing evidence that menaquinone-4 may possess other antiosteoporotic properties that are specifically associated with the geranylgeranyl side chain of this k 2 vitamin. Vitamins d and k are crucial for your health, but some say vitamin d is harmful to those low in vitamin k. Effect of vitamin k deficiency on urinary gamma-carboxyglutamic acid excretion in rats. Pivka-ii plasma levels as markers of subclinical vitamin k deficiency in term infants. Skip the weekly dosing, this is something that doctors do and it’s not effective in creating the best health and improving vitamin d levels. Nutrition during pregnancy: Part i: Weight gain, part ii: Nutrient supplements. Q: Who is at risk for vitamin k2 deficiency? The most important criteria you should keep in mind when choosing a vitamin d3 and k2 supplement are discussed below, so that you are confident that your purchase suits your needs. Now my wife is taking omegavia dha 600, full spectrum vitamin k, choline, calcium and mutivitamin prenatal. Carboxylation is the chemical modification of proteins triggered by the presence of vitamin k. Important information to know when you are taking: Warfarin (Coumadin) and vitamin k. For example, cooked spinach has a 5% bioavailability of phylloquinone, however, fat added to it increases bioavailability to 13% due to the increased solubility of vitamin k in fat.
Modulation of arterial thrombosis tendency in rats by vitamin k and it’s side chains. Vitamin d is very effective when taken in conjunction with vitamin k. Both trials reported the restoration of serum vitamin k and undercarboxylated osteocalcin levels to the normal range after one month of daily supplementation with 1 mg of vitamin k. But k2 supplements analyzed at the university of oslo suggests that some products contain only about 15% of mk-7 in the trans form. Unfortunately, circulating markers of vitamin k concentrations and vitamin k-dependent proteins were not taken into account to get a better mechanistic understanding. The most common sources of vitamin k in the u. Additionally, they give an overview of the current literature indicating potential adverse effects of long-term vitamin k antagonists in this population. Additionally, pth promotes reabsorption of ultra-filtered calcium in distal tubules and activates vitamin d thereby increasing circulating calcium levels by raising gastrointestinal uptake of calcium (17, 18). The mechanisms responsible include Activation of growth-inhibiting proteins requiring vitamin k 2, such as prothrombin, 62 Arylation pathways, 63 Activation of growth arrest genes such as gas 6, 64 and And increased c-jun and c-myc mrna expression in hepatoma cells. These conditions affect your ability to absorb vitamin k, which puts you at risk for deficiency in the long run. To top it off, the vitamin k2 is dissolved in extra virgin organic olive oil, which helps substantially with absorption.
However, newer generations of anticoagulants like eliquis, pradaxa or xarelto do not interfere with vitamin k while providing anticoagulant effects. Prevention of vitamin k deficiency bleeding in newborn infants: A position paper by the espghan committee on nutrition (Pdf). Vitamin k administration to elderly patients with osteoporosis induces no hemostatic activation, even in those with suspected vitamin k deficiency. The recommended adequate intake for vitamin k is based only on vitamin k1 and is set at 90 mcg/day for adult women and 120 mcg/day for adult men. In a study of healthy girls, plasma phylloquinone was inversely correlated with circulating oc concentrations showing that a better vitamin k status was associated with decreased bone turnover in healthy girls. The discovery of vitamin k and it’s clinical applications.