Product name: Doctor’s Best, Vitamin D3, 125 mcg (5000 IU), 720 Softgels
Quantity: 720 Count, 0.22 kg, 12.4 x 6.6 x 6.6 cm
Categories: Doctor’s Best, Supplements, Vitamins, Vitamin D, D3 Cholecalciferol, Non Gmo, Gluten Free, Soy Free
Science-Based Nutrition, Dietary Supplement, Non-GMO, Gluten Free, Soy Free, Helps Support Immune, Heart and Bone Health, Doctor’s Best Vitamin D3 provides D3 (as cholecalciferol) needed for the body to regulate phosphorus and calcium levels for healthy bones, teeth and heart. Vitamin D3 is produced in the skin by absorbing the sun’s UV rays and is obtained from food in limited amounts. Sun protection and climate factors may influence low Vitamin D3 levels. Vitamin D3 is beneficial for immune, cardiovascular, bone density and structure, and cellular function. It plays a role in most organs and systems of the body and influences the chemical messengers of the immune systems, Helps regulate calcium and phosphorus levels needed for healthy bones and teeth, Helps support immune and heart health.
I have also read that you need magnesium for vitamin d to work. I also discuss a reduction in vitamin d supplementation if a patient has a blood level greater than 50 ng/ml. The reason is thought to be because vitamin d is an oily substance that tends to get stored in the body’s fat tissue. While substituting it with exactly measured vitamin d supplements. Unlike cholecalciferol, which is typically only available as a maximum dose of 5,000 units per capsule or tablet, ergocalciferol is available as a monster 50,000 unit dose. The normal liver harbors the vitamin d nuclear receptor in nonparenchymal and biliary epithelial cells. Some meta-analyses make the assumption that vitamin d is a pharmacological agent, and not as a nutrient. A better understanding of how magnesium supplementation might reduce complications related to vitamin d deficiency would help improve patient care. This is mostly due to vigilant sun protection, since sunscreen with spf 30 reduces vitamin d production by 95%. You are likely to get enough vitamin d through food, and increasing your intake of vitamin d through sun exposure is not worth the added risk. Furthermore, vitamin d intoxication also exerts significant undesirable actions on the cardiovascular system via elevations in serum phosphate and serum calcium/calciproteins, impairment of vsmc elastin biology, and inhibition of protective vascular pth/pthrp receptor signaling.
Doctor’s Best, Vitamin D3, 125 mcg (5000 IU), 720 Softgels: D3 Cholecalciferol, Vitamin D, Vitamins, Supplements
I was diagnosed with low vitamin d and after the first prescription i was advised by the chemist that at this strength they were cheaper to buy online. A small study published earlier this month suggested that high-dose vitamin d could reduce redness and inflammation following sunburns, but the dose tested far exceeded the recommended daily dose of vitamin d. Once in the bloodstream, vitamin d undergoes several transformations into a hormone that helps strengthen bones. Role of vitamin d in diabetes mellitus and chronic kidney disease. Affluence was no protection from this disease of insufficient vitamin d and, in fact, may have promoted the disease because pampered children were discouraged from playing outside. Too much vitamin d can be harmful, including (Ironically) increasing fractures, falls, and kidney stones, and can be toxic by causing excessive levels of calcium. Given that both ergocalciferol and cholecalciferol undergo metabolic changes in the human body, which differ from other animals, it should make sense that a binding study in rats may not be sufficient to show equivalence. For asymptomatic patients with vitamin d intoxication, we suggest monitoring of clinical symptoms and serum 25ohd and calcium levels until serum 25ohd values start declining. The lower potency of vitamin d2 (Ergocalciferol) is in line with results of most randomized trials that tested the specific ability of the two vitamin d isoforms to raise and maintain circulating 25-hydroxyvitamin d concentrations.
When the manufacturing method for ergocalciferol was created, binding studies of the vitamin d receptor in rats showed equipotency between ergocalciferol and cholecalciferol. Vitamin d supplementation for the management of knee osteoarthritis: A systematic review of randomized controlled trials. Studies are now testing whether adding various doses of vitamin d to regular treatments can help people with ms. In general, vitamin d 2 is found in fungi and vitamin d 3 is found in animals. A systematic review of randomized, double-blind, placebo-controlled trials examining the clinical efficacy of vitamin d in multiple sclerosis. The immune effects of high vitamin d doses were tested in a few trials in children and adolescents infected with hiv. While symptoms are more or less non-existent, the result of a vitamin d deficiency can be more serious. In fact, vitamin d supplementation remains recommended by experts. Synthesis of vitamin d in nature is dependent on the presence of uv radiation and subsequent activation in liver and in kidney. Pregnant or lactating women, people with existing medical conditions, or people taking medications should consult their health care provider/s before taking any dietary supplement. Most people are not deficient in vitamin d, but they do not have an optimal level of vitamin d either. Osteomalacia is a disease in adults that results from vitamin d deficiency.
This larger dose may be seen as more convenient for patients or healthcare providers who want to provide supplementation on a weekly or monthly basis. Your body produces vitamin d when the skin is exposed to sun, and it is estimated that most people need 1,000 to 1,500 hours of sun exposure throughout the spring, summer, and fall to obtain the necessary amount of vitamin d. Hence, the possibility cannot be dismissed that, because of dosage and compliance problems, changes in vitamin d status in the whi trial might not have been sufficient for observing a substantial influence on the risk of colorectal cancer. Form: D supplements come in tablets, softgels, liquid drops, and gummies. Essential nutrient interactions: Does low or suboptimal magnesium status interact with vitamin d and/or calcium status? All of the enzymes that metabolize vitamin d seem to require magnesium, which acts as a cofactor in the enzymatic reactions in the liver and kidneys. Advocates like the vitamin d council set higher thresholds. The vitamin d metabolites, calcifediol and calcitriol, were identified by competing teams led by michael f. Much debate and uncertainty surround how much (If at all) healthy infants, children, and adolescents should be supplemented with vitamin d. The vitamin also was said to improve athletic performance.
These various stages of vitamin d conversions are actively dependent on the bioavailability of magnesium. Vitamin d is fat-soluble and dietary sources from food or supplements are absorbed via the lymphatic system in the proximal small bowel. In particular, the women’s health initiative (Whi) trial was criticized for the vitamin d3 dose and for the low adherence of women to supplementation (8, 9). The vitamin d council recommends staying in the sun for half the time it takes your skin to turn pink or red. It is critical to immunocompetence and in natural and adaptive immunity, partly by influencing the activity of vitamin d metabolites. One case involved an infant who received a 30-fold overdose of vitamin d when the mother switched over-the-counter formulations from one that contained 400 iu/ml to another that contained 400 iu per drop. The most important steps in vitamin d metabolism are shown in figure 1, vitamin d hydroxylation to 25-hydroxyvitamin d (25Ohd) in the liver depends on substrate availability, and therefore, 25ohd concentrations rise in circulation during excess or intoxication. A human body produces vitamin d as a response to sun exposure. Increased serum 1,25-dihydroxyvitamin d after growth hormone administration is not parathyroid hormone-mediated.
Doctor’s Best D3 Cholecalciferol
Instead, i recommend being careful about sun exposure to protect against skin cancer, and instead taking a daily vitamin d supplement to avoid deficiency. At baseline, the children with rickets were much shorter with worse growth velocity than the healthy controls, whereas after the vitamin d treatment, the auxological parameters (Length and growth velocity) had significant improvement. The major natural source of the vitamin is synthesis of cholecalciferol in the lower layers of skin epidermis through a chemical reaction that is dependent on sun exposure (Specifically uvb radiation). Inverse associations were found between increases in 25-hydroxyvitamin d levels and the baseline serum 25-hydroxyvitamin d levels or the concomitant intake of calcium supplements, but these associations were not statistically significant. All infants and children are advised to take a vitamin d supplement containing 400 international units (10 Micrograms) of vitamin d, starting within days of birth. As far as i know, if you are no longer taking the supplement, your vitamin d level should slowly go down on it’s own. Because vitamin d toxicities relate in part to abnormal serum and vascular calcium phosphate homeostasis, recommended daily intakes of vitamin d and vdra treatment should incorporate consideration of this important physiological decline commonly seen in aging.
In a clinical setting, vitamin d (In combination with calcium) is most often used to treat and reverse conditions resulting in thin, brittle, and fragile bones: Rickets in children, ostemalacia in adults, and osteoporosis in older adults. Vitamin d3 can be taken as a supplement to improve overall health or used to treat osteoporosis. Vitamin d is crucial in calcium and vitamin d metabolism, as it’s absence around 15% of dietary calcium and 60% of phosphorus is absorbed. Bethesda, md: Office of dietary supplements, us national institutes of health. Although people can take vitamin d supplements, it is best to obtain any vitamins or minerals through natural sources wherever possible. The evidence for ensuring high-risk groups such as pregnant women, children and those from the middle east and african countries is vitamin d replete with either dietary, sunlight or combination with appropriate vitamin d supplements at moderate doses. In the absence of certain health problems, a low vitamin d level is unlikely in someone who takes a daily supplement. One doctor of mine says i should only be at 25 ng/dl and has demanded i stop taking vitamin d3 supplements. 14, 70- 72 The effectiveness and clinical benefits of vitamin d are significantly reduced when magnesium homeostasis in the body is not maintained. In the united states, commercially fortified cow’s milk is the largest source of dietary vitamin d, containing approximately 100 international units (2,5 Micrograms) of vitamin d per 8 ounces.
The diagnosis of vitamin d intoxication is based on elevated serum 25ohd concentrations, which are associated with hypercalcemia or hypercalciuria, whereas serum 1,25(Oh) 2d levels are normal and pth is suppressed. Additional studies are needed to determine the potential fracture risk posed by high-dose vitamin d, particularly in patients at risk for fractures and osteoporotic changes. Had severe vitamin d deficiency which caused my calcium levels to decline – this gave me back pain, restless legs, knee pain, weakness and depression. Before you start taking supplements, talk to your doctor about the right dosage for you. There’s also very little evidence supporting the use of vitamin d in preventing acne. People deficient in vitamin d may also experience increased testosterone levels after supplementation. D3 (Cholecalciferol) for vitamin d deficiency: Having severe bone loss, my md put me on vitamin d2 at 50,000 units a week. Under physiological conditions, 1,25(Oh) 2d has high affinity for the vitamin d receptor (Vdr), making it the active vitamin d metabolite. As a vegetarian person who looks deeply cares about my health, animals and environment, it was very important to find as pure and clean vitamin d as possible.
There is a paucity of cause-and-effect data surrounding vitamin d supplementation, but an abundance of associative data regarding low vitamin d levels. Experts call for more studies, and this statement cannot be more compelling than in pediatrics where data on the safety and long-term use of high vitamin d doses are limited. One study showed that 96% of people who had experienced heart attacks were low in vitamin d.
Doctor’s Best, Vitamin D3, 125 mcg (5000 IU), 720 Softgels Product Review
Great vitamin about a nice price.3 naive questions about vitamin D. D 10. 000. Worker D3. Not for permanent admission.5000 IU drink with a deficiency of vitamin D, established by blood tests, short courses, on the recommendation of a doctor. High dosage. I recommend. Good vitamin. recommend. Drinking The Whole Family All Year
I am an office worker, I live in the middle lane. An analysis conducted in the summer revealed an acute shortage of vitamin D. The endocrinologist prescribed a daily dose of Vit D at a dose of 5000 IU. Seeing on a jar that this dose is 625% of the daily norm, I was finally amazed. But I really trust my endocrinologist, so I began to take it calmly. Daily, simultaneously with omega (750 mg) in the morning after eating. Improved mood and sleep. Repeated analysis showed replenishment to the lower limit of the norm, I continue to take further. A very important vitamin for our body! It is great that now it can be taken in a convenient form once a day, without suffering from drops. Good quality and nice price!
1. WHOM DO I ACCEPT THIS PREPARATION? This drug, like any synthetic vitamin, is better not to take at all. Vitamin D is better to get out of food / to regularly visit the sun. But D3 is perhaps one of the few synthetic vitamins that official medicine did not say categorically “no” as a means of preventing a number of serious diseases (primarily prostate and breast cancer). In particular, the Canadian Cancer Research Association recommends that all residents of Canada take 1000 IU of Vitamin D3 every day during the winter months, since there are few sunny days in winter. And people over 65 years old and those who do not get much exposure to the sun should take vitamin D3 all year round. In the latter case, it is desirable to monitor the vitamin D content by quarterly blood tests.2. IS THERE A DIFFERENCE WHICH VITAMIN D RECEIVE? Yes, it is better to drink D3 (Cholecalciferol) – as in this drug. Vitamin D2 (Ergocalciferol), according to several studies, can be toxic.3. DOES THERE HAVE SUCH A HIGH DOSAGE OF 5000 IU? Because vitamin D3 is fat-soluble – the body can create its depot. Therefore, vitamin is not necessary to take daily. In particular, if you want to follow the preventive dosage recommended by the Canadian Cancer Research Association (see above), you can take 1 capsule from Doctor’s Best 1 every 5 days. For comparison: stay in the midday sun for 20 minutes provides a synthesis of 8,000 to 10,000 IU of vitamin D. If you want to take 1 capsule from Doctor’s Best daily, you should consult a doctor. More reviews – on my page The-best. I hope it helps you to choose the best on Ayherbe. I will be grateful if you press YES!
Since I lead a completely dissolute life with daily intake of alcohol and other temptations of this world, I do not have the opportunity to fully appreciate the properties of the drug. I really believe that it is thanks to him that I can still consciously write reviews.
I take vitamin D3 continuously for 4 years, 5 thousand units. since the beginning of this summer, I accept 10 thousand units, i. e.2 capsules, despite the fact that I travel to the sea. By the way, if you have a normal level of vitamin D3 in the body, your skin does not burn on the skin, and quickly recovers, even if you forgot to update the cream. Do not believe who writes here that you can get it by walking along the streets for 20 minutes. This is complete nonsense. As well as getting an overdose, our standards are outdated a long time ago at 400 IU daily dose will not work. The lack of this hormone, and this hormone is very important for the work of our entire body, almost the entire population of Russia lives with a lack of this vitamin, a large number of people get sick and die from cancer every year. From the lack of this vitamin (hormone) there are 18 types of cancer, it has already been proven. It can be obtained only when the sun is at its zenith and you stand 30 minutes as naked as possible WITHOUT SPF PROTECTION, in this case you will receive 2000ME. Vitamin D3 plays a large role for the immune system, without it, aging comes faster, for women in this regard it is important, with its lack of menopause comes sooner. My family constantly takes 5 thousand units. For 4 years of admission, all have increased immunity. During this time, they ceased to hurt. Even what snot is, no one remembers. Tissue regeneration and healing is mega fast. And he needs to be constantly supported, he quickly leaves, if suddenly stress, if suddenly there was an operation, if they suddenly took antibiotics. I recently passed his level after constant admission and he was 89, I want to raise to 100 and maintain the level constantly. So everyone’s health, and don’t listen to the ravings about the overdose that you can get if you take 50,000 IU. up to 10,000 are normal doses, especially in winter.
I wrote articles on vitamin D and calcium in my blog. These two elements depend on each other – vitamin D contributes to the absorption and regulation of calcium in our body. Articles will be useful to those who are just thinking about taking vitamin D and calcium, and those who already drink them. The latter will be able to compare the adequacy of their dosages with the norms proposed by the Russian Association of Endocrinologists (RAE)? It is known that vitamin D must be taken additionally as supplements, because it is low in foods, and the synthesis of vitamin D in the body under the action of UV is hampered by many factors? THIS VITAMIN D-3 from Doctor’s Best contains a dosage of 5000 IU in a single capsule. Vitamin D3 here from lanolin – wool sheep fat. This is the most common method of obtaining natural – natural vitamin D3. For better absorption of vitamin D3, extra virgin olive oil was added to the gelatin capsule? However, this dosage is above the safe upper limit and is not suitable for permanent prophylactic administration. This dosage is corrective, drink it with a deficiency of vitamin D, established by blood analysis 25 (OH) D, in short courses, as recommended by the doctor. An overdose of fat-soluble vitamins, which include vitamin D, is more difficult than a deficiency? The Russian Association of Endocrinologists recommends daily prophylactic intake of vitamin D in dosages: children up to a year – 400 IU, from 1 year to 50 years – 600 IU, 50 years and older – about 800-1000 IU, pregnant and nursing – 800 -1000. Preventive dosages do not require correction even during active sun exposure.1000 IU can be attributed to the optimal prophylactic dosage of an adult. Now Foods, for example, has vitamin D in the 1000th dosage, I like it very much, I added it to my list of favorite foods on my reviews page.
The famous vitamin D3 – tens of thousands of articles have already been written about it, how it is useful and how much it is needed. The main factors you need to know about it: we cannot get vitamin D3 from food, the only way to saturate our body with this vitamin is to be in the sun. Unfortunately, today, due to our meager lifestyle in nature, and living in the northern latitudes of our planet, people do not physically receive the right amount of vitamin D3. Not only do we have half a year, it is gloomy and not sunny in the cold season, but in the summer of good weather, too, has become scarce lately. And in addition, people simply have no time to be in the sun, even in the summer, because of today’s high pace of life. Personally, I think that vitamin D3 should be taken from around the beginning of November to the end of February. Many will say “what are you, we don’t have enough of it in the summer and we need to drink it in the summer”, you can’t take one vitamin all year round so that different paid scientists do not say there in order to increase sales of supplements. The body itself must also produce this vitamin; the body, after all, produces vitamin D3 in any case in the summer, but its greatest need is in the period that I wrote about above. What is most important to know about the benefits of vitamin D3 – regulating the balance of calcium, phosphorus and magnesium; regulates hormones; spreads elements throughout the body; promotes cells to divide properly; promotes the correct exchange of processes; supports vision. This is only an insignificant part of everything that this vitamin is needed for, the spectrum of benefits of vitamin D3 is huge. As for the dosage, the dosage should be adequate. I myself have witnessed how a person, due to a high dosage of vitamin D3, developed sand in his urine, the so-called oxalates, that is, organic salts. This is serious. A person may not know for weeks about his metabolic disorder until his urine turns red. I will share with you only my personal opinion on the correct dosage of vitamin D3, based on adequate statistics from scientists from different countries. Children under 12 years of age cannot even come close to this. For children from 12 to 18 years, the dosage should not exceed 400 IU / day. For adults, for prevention, the dosage should not exceed 1000 IU / day. For therapeutic purposes, everything is individual and everything is strictly according to the doctor’s recommendations.
Very good vitamin D3. Wellness has improved. Small capsule, comfortable to receive. The whole family accepts with pleasure!
A good budget option, in that dosage, which is recommended for filling the deficiency of vitamin D3. In the cold season, she drank two capsules. The skin first felt the use of this drug. became less dry.
good dose for prevention
I drink even in the summer, the beautician said to drink all year round, the tan is even less on the skin if he is in sufficient quantities.
Questions and Answers
Where is the D3 sourced from? After feeling like a complete idiot (from taking a D3 supplement that was made with Soybean Oil), I want to make sure this is a truly Non-GMO D3, and something that is truly GMP safe. Please do not tell me to go to the manufacture for the info, (I would appreciate an independent, honest response).
what is the price in US dollars?
Do you have D3 in veggie/fish softgel?I dont like bovine gelatin
Is it possible to use this pills in case you are pregnant or nursing?
Is the gelatin of the pig or not? please answer
i am 30 years old man should i take this?
Is the softgel animal based or plant based?
Hi, I would like to purchase Vitamins D3 5000 iu. All the time out of stock. When it will be available? Thanks
Hi Seller, This product is halal? This subtible for Muslim? plz reply. Thanks
I have been taking this for quite a while and I rate it very highly. I too will not put anything in my body if it contains soy and this company states the product does not contain any soy.
When I bought this last 11/9/18, each bottle of Vitamin D3 2000 IU, 180 softgetls, cost US$6.20. Hope this helps.
Foodpharmacy Blog’s house brand contains the same potency in a fish softgel (/pr/California-Gold-Nutrition-Vitamin-D-3-5-000-IU-90-Fish-Gelatin-Softgels/70316). I have used the California Gold product with great success and recommend it highly. I recently had my vitamin D levels tested for the first time and it was an excellent 60! Not bad for someone who works overnights and lives in a northern climate.
It is always best to check with your doctor or equivalent during pregnancy and when breastfeeding as to what supplements to take. It doesn’t hurt to do some research first and if you are taking prenatal vitamins, check concentration of D3. Here is a link to Medscape article about this question: https://www.medscape.com/viewarticle/852915 This article supports additional D3 especially during winter months of reduced daylight hours.
Really I don’t know. l hope someone can help you.
It depends upon how much sun exposure you receive on a daily basis as well as your geographical location. A good many health practitioners are now finding signs of Vitamin D deficiency in clients who have shunned the sun out of fear of skin cancers. I have read that unless you’re exposed to sunshine in regular daily quantities, then most people are likely to be deficient in Vitamin D3, and more so for those in colder climates, or those who, for religious reasons, wear more clothing. Discussion with a health care practitioner would be advisable. I also recommend taking Lycopene if out in the sun on a regular basis.
What’s your question?
I am a Christian and don’t care about my food being Halal. That is something you would have to ask the company. I’m sorry.