Product name: Doctor’s Best, Natural Vitamin K2 MK-7 with MenaQ7, 100 mcg, 60 Veggie Caps
Quantity: 60 Count, 0.05 kg, 5.3 x 5.3 x 9.7 cm
Categories: Doctor’s Best, Supplements, Vitamins, Vitamin K, Vegan, Non Gmo, Gluten Free, Soy Free
Science-Based Nutrition, Natural Vitamin K2, A Superior Form of Vitamin K for Healthy Bones and Soft Tissue, Vegan, Dietary Supplement, Non-GMO, Gluten Free, Soy Free, Natural Vitamin K2 with MenaQ7provides the superior form of vitamin K for optimum bioavailability and delivery to the body. Vitamin K isn’t one vitamin, it’s a family of fat-soluble vitamins with similar chemical structures but different metabolic properties. K2 belongs to a group of vitamin K compounds called menaquinones, which show greater bioactivity when compared to K1, the ordinary supplemental form. K2 is absorbed more completely, remains in the body longer and delivers more benefits for bones, blood vessels and other soft tissues, Helps support bone health and soft tissue elasticity, Highly effective delivery of vitamin K to bone and soft tissue, Helps support calcium metabolism for meaintenance of healthy bone.
A vitamin d3 and k2 combination supplement is especially beneficial to older women and helps prevent osteoporosis. According to the ods, vitamin k deficiency affects very few adults in the united states. I want to be clear, just because these are the supplements that my doctor approved of, it might not be the best for you! 37 In another 3-year, double-blind, placebo-controlled trial, vitamin d and vitamin k were investigated. However, these products must be used for at least 6 months to resolve an acute case of hypovitaminosis. It is also available in dietary supplements containing only vitamin k or vitamin k combined with a few other nutrients, frequently calcium, magnesium, and/or vitamin d. Metabolism and cell biology of vitamin k. They can increase your vitamin k intake. In such high doses, though, vitamins are often classified as drugs, rather than food supplements. The vitamin d3 form is three times more effective than the d2 and has less in the way of side effects than vitamin d3! Both trials reported that in patients who had low levels of vitamin k measured in the blood and also another laboratory marker of vitamin k (Undercarboxylated osteocalcin), these levels returned to the normal range after one month of daily supplementation with 1 mg of vitamin k. The structure of phylloquinone, vitamin k 1, is marked by the presence of a phytyl group.
Doctor’s Best, Natural Vitamin K2 MK-7 with MenaQ7, 100 mcg, 60 Veggie Caps: Vitamin K, Vitamins, Supplements
Research has shown that too little vitamin k is associated with various age-related concerns, such as cognitive function, heart health, and mobility. When vitamin k 1 is given to patients with warfarin, a more stable international normalised ratio (Inr) has been noted. Gla-rich protein is a novel vitamin k-dependent protein present in serum that accumulates at sites of pathological calcifications. As a dietitian, when i used to counsel individuals, there were several occasions when my clients brought in shopping baskets filled with supplements. The potential mechanisms, although not yet fully understood, implicate vitamin k-dependent proteins, including matrix gla protein (Mgp) and the newly described gla-rich protein (Grp). They require vitamin k for carboxylation in order to function properly. This matches the most recent recommendations from the office of dietary supplements at the national institutes of health, which cites a target intake of 120 mcg per day for adult males and 90 mcg per day for adult females (24 ). However, both menaquinones were found in tgrlp and low-density lipoproteins, and mk4 was even present in high density lipoprotein. In some cases, fortified foods and dietary supplements may be useful in providing one or more nutrients that otherwise may be consumed in less-than-recommended amounts.
Pilkey et al 70 demonstrated that 29% of patients with haemodialysis have coexisting subclinical vitamin k deficiency. Foodpharmacy Blog and it’s editors do not ensure that unforeseen side effects will not occur even at the proper dosages, and thereby does not assume liability for any side effects from supplements or practices hosted under the domain of examine. Vitamin k is a group of fat-soluble vitamins that share similar chemical structures. Less common adverse side effects: Some unpleasant symptoms have been reported with the use of vitamin d3 and k2 supplements, such as nausea, vomiting and severe abdominal pain. This means the supplement is extremely pure and extremely well absorbed, because the fat-soluble vitamin k2 is ingested in a dissolved format already. The disbalance between vitamin d and vitamin k promotes an environment in which excess calcium will be deposited into our vascular tissue instead of bone. Average diets are usually not lacking in vitamin k, and primary deficiency is rare in healthy adults.
In addition to blood clotting and bone health, vitamin k also seems to play an important role in preventing heart disease. Newborn babies who are exclusively breast-fed are at increased risk for vitamin k deficiency, because human milk is relatively low in vitamin k compared to formula. Worldwide, a large group of people is prescribed to a supplemental regime of both vitamin d and calcium. Do any supplements help prevent or treat osteoporosis? Few data are available on the relative bioavailability of the various forms of vitamin k supplements. Table 2 summarizes vitamin-k dependent proteins involved in calcification. Vitamin k supplement along with vitamin d and calcium reduced serum concentration of undercarboxylated osteocalcin while increasing bone mineral density in korean postmenopausal women over sixty-years-old. Although both have demonstrated bone health benefits, mk-7, for several reasons, activates the greatest proportion of osteocalcin and is the preferred form for supplementation. Prevention of vitamin k deficiency bleeding in newborn infants: A position paper by the espghan committee on nutrition (Pdf). 2 Worldwide, the food richest in vitamin k2 is soybeans fermented with the bacterium bacillus subtilis. According to this review, vk supplementation showed no benefits for the reduction of neonatal bleeding but for maternal plasma vitamin k1 status. 38 Evidence demonstrates that the vitamin k requirement for carboxylation of osteocalcin is not met by usual dietary intakes but that carboxylation readily responds to phytonadione or menaquinone supplementation.
The function of vitamin k 2 in the animal cell is to add a carboxylic acid functional group to a glutamate (Glu) amino acid residue in a protein, to form a gamma-carboxyglutamate (Gla) residue. This study shows the differential effects of vitamin k and vitamin d supplementation on calcium balance in young rats fed with a normal or low calcium diet. If you have enjoyed our guide about vitamin d3 and k2 supplements, please leave a comment and share this article in your social media platforms. You may have thinner blood, but you may also increase arterial calcification with the medically-induced vitamin k deficiency. However, some experts fear that very high levels of vitamin d and calcium could result in the deposit of this mineral in places where it can be detrimental to your health. The function and metabolism of vitamin k. My wife and i were discussing how much vitamin a for her to shoot for in her diet or supplementation before and during the hopeful upcoming pregnancy. The combination of vitamins d3 and k2 has made a big impression in the world of supplements. The role of vitamin k in haemorrhage in the newborn period.
Doctor’s Best Vitamin K
A 3-year study in 244 postmenopausal women found that those taking vitamin k2 supplements had much slower decreases in age-related bone mineral density. Several proteins involved in blood clotting depend on vitamin k to get their job done. Research has shown first and foremost that the forms of vitamin k are not toxic at any reasonable/rational dosage. Q: What vegan foods are high in vitamin k2? Further, potential interaction between vitamin k status and polymorphisms of the vitamin d receptors was investigated. Make sure you add this incredible supplement pair to your regime! In both bone and vascular tissue, vitamin k-dependent processes play an important role in calcium homeostasis and it is tempting to speculate that vitamin k supplementation might protect from the potentially untoward effects of calcium supplementation. This topic review will focus on vitamin k. Coagulation meets calcification: The vitamin k system. If you follow our advice, you can get the most out of your vitamin d3 and k2 supplement combination.
Substantially different from calcium from dietary sources, calcium form supplements induce an acute rise in serum calcium levels that highly oscillates in blood for up to 6 h (15, 16). My suggestion is to get a lot of summer time sun exposure and rely of d3 supplements during winter and spring. An excellent selection of k2 supplements can be found on amazon. However, substantial concentrations of undercarboxylated gla proteins are found in the circulation of people who do not take vitamin k supplements, suggesting that the rda should be higher. Sports research makes a high-quality vitamin k2 supplement that uses the proprietary chickpea extract mk-7 as it’s source for the vitamin. Now my wife is taking omegavia dha 600, full spectrum vitamin k, choline, calcium and mutivitamin prenatal. Mk-7 (Menaq7) supplementation in patients with ckd3-5 significantly reduced circulating levels of dp-ucmgp.
Routine supplementation, however, is not justified until these results are confirmed in a large pragmatic rct with fractures as the main outcome. Biosynthesis of vitamin k (Menaquinone) in bacteria (Pdf). Not all studies observed synergistic effects of vitamin d and k supplementation. Vitamin k 2 (As menaquinones mk-4 through mk-10) intake level is inversely related to severe aortic calcification and all-cause mortality. When taken together, these two nutrients make an unbeatable team, providing the advantages of colecalciferol, and at the same time, lowering the severity of the unwanted side effects of vitamin d3 alone. However, a systematic review and meta-analysis of the effects of calcium supplementation along with vitamin d treatment showed that this treatment was not associated with a lower incidence of fracture risk in adults, questioning whether calcium supplementation contributes to the maintenance of healthy bone. Conversion of dietary phylloquinone to tissue menaquinone-4 in rats is not dependent on gut bacteria. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. So the thought sequence goes like this: Tooth development occurs in weeks 5 thru 12, menaquinones are required for tooth/jaw development. Gla-containing proteins (Mgp and osteocalcin) regulate many anticalcification and bone-forming processes in the body, which are dependent on vitamin k in order to be produced.
In infants, vitamin k deficiency may result in life-threatening bleeding within the skull (Intracranial hemorrhage). An increasing amount of randomized controlled trials have demonstrated the combined effects of vitamins d and k on postmenopausal osteoporosis mostly pursued in japan with a study duration between 8 weeks and 3 years (Table 1). Because a synthetic form of vitamin k, vitamin k 3 (Menadione), may be toxic by interfering with the function of glutathione, it is no longer used to treat vitamin k deficiency. Low-dose menaquinone-4 improves gamma-carboxylation of osteocalcin in young males: A non-placebo-controlled dose-response study.
Doctor’s Best, Natural Vitamin K2 MK-7 with MenaQ7, 100 mcg, 60 Veggie Caps Product Review
An obligatory addition to vitamin D. Synergist Vitamin D -3! Bone strengthening. Take with Vit. D. Vitamin D3 Needs Vitamin K2 To Get Calcium To The Bones. Drink Scheme Together With D3. Swicth. Natural Vitamin K2 MK-7 with MenaQ7, 100 mcg, 60 Vegetable Capsules. I drink with vitamin D. Arteries Helper
I take vitamin D, the benefits of which have already been written and told, but it has a nuance – in high doses it can contribute to calcification, especially if you take extra calcium (which for women after 30 – it is necessary!). And calcification can be in the most unexpected places. Whatever it is, it is necessary to take this form of vitamin K. If not difficult, click Yes.
I take this supplement in combination with vitamin D-3, because vitamin K-2 in the form of MK-7 100? g is needed for every 10,000 IU of vitamin D3, for better absorption and to avoid the occurrence of sand in the kidneys. In the absence of vitamin K2, calcium circulating in the body, which is absorbed from food by vitamin D, is also deposited in the soft tissues of the body and in arteries leading to atherosclerosis. Therefore, vitamin D3 should always be taken in combination with vitamin K2. These two vitamins work together, and calcium obtained from food is deposited in the bones, not in the arteries. In addition to its magical properties in the complex work with vitamin D-3, Vitamin K-2 is a new nutrient that supports the cardiovascular system, because clinical studies have confirmed that it provides what no other compound can give: a decrease in arterial stiffness. But not all K2 have shown this health benefit. MenaQ7 – is the only vitamin K2 as MK-7, specifically used in revolutionary clinical trials, which makes it the only K2 patented for cardiovascular disease. Recommend.
I break my femur and drink it to strengthen my bones.
If you drink high doses of vit. D, then this drug is simply necessary.
Vitamin K2 used to be in our food before food processing came along. You need it to have calcium reach your bones. Vitamin D3 gets the calcium into the blood stream and K2 takes it from there to the bones. I take this supplement and gouda cheese daily to insure an adequate amount of K2. Read the book “Calcium Paradox” for the technical details.
I’m happy, there are no side effects.
I just learned that K2 is what you want to eat if you need to strengthen your bones. Not calcium. So i have swithed to K2
I drink 10,000 vitamin D every 3 days after breakfast and 1 capsule K2.
I think it works but it’s slow. I guess it’s a function of how much calcium you have in your arteries. The more you have the the more time it takes to remove it.
Questions and Answers
This product is not soy, therefore what is the m7 ingrediant. I would like k2 with fermented chickpeas
how much cis isomers does each cap have?
MenaQ7 manufactures both a synthetic K2 (called PharmaPure) and a three other grades which are naturally fermented K2. Is the MenaQ7 K2 used in these capsules obtained from natural fermentation or synthetic? I would prefer the naturally fermented MenaQ7 K2.
Does this product have the Prop 65 warning?
Naturally derived Vitamin K2 as MK-7 uses a fermentation medium with chickpea protein and Bacillus licheniformis. The result is a MenaQ7 variety free from all known allergens including soy. A proprietary multi-step process of purification, condensation, and crystallization produces a product that is more than 96% pure, natural, all-trans MK-7. In addition, MenaQ7 Natural is: Non-GMO certified Suitable for Vegans and Vegetarians Gluten free Free of cis-isomers
It has zero cis-isomers.
This one is from fermentation according to Doctor’s Best website. MK-7 K2 sourced from fermentation is always superior to MK-7 K2 sourced from chemcal synthesis because fermentation only produces the trans isomer whereas chemical synthesis usually contains a combination of trans and cis forms. The cis form of MK-7 K2 don’t exist in nature and probably useless in the body. It might also antagonize or interfere with the body’s efficient utilization of the trans MK-7 K2 isomer.
There is no Prop 65 warning on the vitamin K2 (menaquinone). You can see what’s listed, if you go to the prop 65 website: https://www.p65warnings. ca. gov/