Product name: Dr. Mercola, Vitamin K2, 180 mcg, 90 Capsules
Quantity: 90 Count, 0.07 kg, 9.4 x 5.1 x 5.1 cm
Categories: Dr. Mercola, Supplements, Vitamins, Vitamin K, Soy Free
Premium Supplements, 180 mcg Per Capsule, Dietary Supplement, Soy Free, Could your cardiovascular health or your “vascular age” be a more accurate indicator of your health and longevity? Some cardiovascular experts today believe so, Your arteries need to remain elastic and flexible in order to effectively transport blood and nutrients to all your cells and tissues. Researchers now realize much of that depends on your body’s balance of vitamins K2, D, and calcium, You want calcium to go to your bones and teeth, and not your arteries and organs. A protein called MGP (matrix Gla protein) is key for preventing the unwanted buildup of calcium in your arteries and requires vitamin K2 to function. Researchers have discovered that healthy arterial tissues contain up to 100 times more vitamin K2 than calcified arteries, Restoring blood levels of vitamin K2 can potentially help reverse the buildup of calcium caused by a vitamin K2 deficiency. Considering that an estimated 97 percent of the Western hemisphere may be deficient in vitamin K2, this is a nutrient you don’t want to ignore, MyVitamin K2supplies a nutritional dose of 180 mcg of a patented form of vitamin K2, MenaQ7. This isthe first and only clinical proven.
Summary vitamin k2 plays an essential role in bone metabolism, and studies suggest that it can help prevent osteoporosis and fractures. Do any supplements help prevent or treat osteoporosis? Q: Does vitamin k2 interact with vitamin d3? All studies but 1 showed an advantage of phytonadione and menaquinone in reducing bone loss. Population-based studies and clinical trials have linked k-vitamin status in children to the creation of strong and healthy bones. Vitamin k supplementation promoted the reduction in urinary calcium excretion and stimulated intestinal calcium absorption in rats on a normal calcium diet. I follow the recommendation of a nutrologist, allied to vitamin d3 supplementation and use it in a preventive way! Yet, observational studies are not designed to making causal inferences, and only randomized controlled trials can evaluate whether phylloquinone may have beneficial effects on bone health (See vitamin k supplementation studies and osteoporosis). An excellent selection of k2 supplements can be found on amazon. It creates a window of opportunity to supplement vitamin k in the abovementioned subgroups including ckd patients and post/peri menopausal women frequently deficient in vitamin k. There remains a need for suitable biomarkers or clinical endpoints that can be used to determine vitamin k requirements among adults. 100% Vegan supplements, products that contain other vitamins, minerals or plant extracts and those available from well known-brands may come with a higher price tag. All of these perks make it one of the best k2 supplements out there.
Dr. Mercola, Vitamin K2, 180 mcg, 90 Capsules: Vitamin K, Vitamins, Supplements
One was a dose-ranging parallel group trial in children (Aged 8 to 18 years); and the other (With an older cohort) had a cross-over design comparing supplements to no treatment, but no separate data were reported for the first intervention period. The main source of vitamin k1 is green vegetables, Whereas vitamin k2 can be found in fermented foods such as soy beans, cheese, and sauerkraut. There is also increasing evidence fat-soluble vitamin k is needed to help build strong bones. Therefore, adequate amounts of vitamin k make certain calcium is properly delivered to bones and arterial health is maintained. I had ordered country life natural vitamin a and d3 last week along with the thorne mk4 and it was delivered today! Background observational and some experimental data suggest that low intake of vitamin k may be associated with an increased risk of fracture. The extra carboxyl group in gla made clear that vitamin k plays a role in a carboxylation reaction during which glu is converted into gla. Several observational studies have suggested that vitamin k2 is better than k1 at reducing these calcium deposits and lowering your risk of heart disease (18, 19, 20).
More research on the stimulating role of vitamin d on vitamin k-dependent proteins is urgently needed to study the underlying mechanisms. Sufficient quantities of vitamin k in the body are necessary for the activation of these proteins in the body to take place, which then allows the proteins to bind calcium, and to move it around, and to function as an essential regulator of calcium and magnesium metabolism within the body, and specifically in bones, the heart, the arteries, the kidneys, teeth, etc. Simplified overview of potential synergy between vitamins d and k and bone and cardiovascular health. Vitamin k 2 includes a range of vitamin k forms collectively referred to as menaquinones. Malabsorption of fat and fat-soluble vitamins (A, d, e, k) may occur and can cause subclinical deficiencies of some of these vitamins. They both are co-factors for an enzyme that catalyzes the carboxylation of glutamic acid residues on vitamin k-dependent proteins. The body will mainly use vitamin k1, which is much more abundant in our food. Safely dosing vitamin e has always been a challenge until this puzzle piece was revealed to me. Several hormones and growth factors, including vitamin d but not vitamin k, regulate osteocalcin synthesis by osteoblasts.
Role of vitamin k2 in the development of hepatocellular carcinoma in women with viral cirrhosis of the liver. One 10-year population study, the rotterdam study, did show a clear and significant inverse relationship between the highest intake levels of menaquinone (Mainly mk-4 from eggs and meat, and mk-8 and mk-9 from cheese) and cardiovascular disease and all-cause mortality in older men and women. I highly recommend it to all those who need a boost on k-2 vitamin (Specially if they do not have much fermented food that would provide it to the body). 1 A few years later, american biochemist edward adelbert doisy determined the chemical structure of vitamin k and succeeded in synthesising it. Important information to know when you are taking: Warfarin (Coumadin) and vitamin k. There is some intriguing evidence that menaquinone-4 may possess other antiosteoporotic properties that are specifically associated with the geranylgeranyl side chain of this k 2 vitamin. The ageing population – especially in major markets like europe, japan, china and the us – is also having an impact on supplement sales, with an increase in osteoporosis resulting in more interest in bone health. Population uses calcium supplements. 1 – 4 In contrast, the evidence for supplementation with vitamin d (Cholecalciferol) with or without calcium is equivocal. In some cases, fortified foods and dietary supplements may be useful in providing one or more nutrients that otherwise may be consumed in less-than-recommended amounts.
Some observational studies support the hypothesis that optimal concentrations of both vitamins d and k support bone mineralization and lower fracture risk. Replacing dietary saturated fats like butter and cheese with monounsaturated fats found in olive oil and canola oil will increase dietary vitamin k intake and may decrease the risk of cardiovascular disease. Menaquinones, bacteria, and the food supply: The relevance of dairy and fermented food products to vitamin k requirements. A recent review summarizing the use and efficacy of calcium supplementation in treating osteoporosis and fracture risk questions the use of calcium supplements because of the weak beneficiary effect on fracture risk while increasing the risk on gastrointestinal problems, kidney stones, and cardiovascular risk. I have never supplemented with calcium, assuming i got enough in my raw milk. Warfarin works by blocking recycling of vitamin k, so that the body and tissues have lower levels of active vitamin k, and thus a deficiency of vitamin k. Keeping vitamin k intake consistent from day to day can prevent these problems. The science certainly shows a greater need for mk-4 over mk-7, i think you need mk-4 more than mk-7, i take both and eat cheese for the longer mks like mk-8 and 9 that are not available as supplements. Vitamin k supplements have been clinically tested to increase bone density and reduce fractures, as well as to improve cardiovascular function, but results have been mixed, so it is not clear that supplementation will help (See what it does).
Dr. Mercola Vitamin K
Moreover, a normal carboxylated mgp protein in the serum may not necessarily indicate a normal vitamin k status, as carboxylated mgp in the serum could be normal, but suboptimal in the arteries (Where vitamin k 2 is needed to prevent vascular calcification). To execute it’s physiological function, oc needs to be activated by carboxylation, catalyzed by vitamin k. A prospective cohort study in 807 men and women, 39-45 years of age, did not find any correlation between dietary phylloquinone intake and coronary artery calcification, as measured non invasively by computed tomography. Supplements are widely available at reasonable cost, and may be more effective when taken with vitamin d. Additionally, vitamin k may even play a vital role in the stabilisation of inr control for patients on warfarin. Our body utilizes all three vitamin k forms to achieve optimal cardiovascular, bone, and blood health. Vitamin k can interact with some drugs, especially blood thinners, so it is important for people taking prescription medications to speak to their doctor before using a dietary supplement. Vitamin d2 can be found in some vegetables, while eating food products derived from animals certain mushrooms increases reserves of vitamin d3 in the body. Unfortunately, vitamin k status was not measured which would have given valuable insight into the association between vitamins d and k with calcium excretion.
On the basis of previously presented data, warfarin may increase arterial calcifications and osteoporosis through the inhibition of vitamin k. I’ve heard it’s best to take fat-soluble supplements, like coq10, curcumin, and vitamin d, with fats or oils to increase absorption. Do supplements derived from natto still carry these potential estrogenic properties, or are they pretty much reduced to just the vitamin content? Circulating 25(Oh)d is further metabolized by the kidney for full biological activity into it’s most active form 1,25-dihydroxyvitamin d (1,25(Oh)d) also known as calcitriol. I want to be clear, just because these are the supplements that my doctor approved of, it might not be the best for you! Research has shown that vitamin k is an anticalcification, anticancer, bone-forming and insulin-sensitising molecule. In koncentrated k, we provide vitamin k at a level beyond what one could eat on a daily basis. Summary: It is best to incorporate a variety of food sources of both vitamin k1 and k2 in your diet to obtain the health benefits that these vitamins offer. However, recent data challenge the assumption that calcium supplementation improves bone mineral density. K complete provides vitamin k1, k2 as mk-4, and k2 as mk-7 in a single soft gel.
Some scientists are convinced that vitamin k2 supplements should be regularly used by people at risk of heart disease. Competing interests: Dr dinicolantonio works for a company that sells vitamin k but he does not directly profit from their sales. Food and dietary supplement labeling purposes, the amount in a serving is expressed as a percentage of daily value (%Dv). Swanson premium brand vitamin k-1 is an effective, economical source of this vital nutrient. Sports research makes a high-quality vitamin k2 supplement that uses the proprietary chickpea extract mk-7 as it’s source for the vitamin. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. Unfortunately, we could not analyse the data from this second trial because the investigators did not report data just from the first part of the trial (Only from the end of the trial when all volunteers had been in both groups), so we could not tell if the effects were due to supplements or no supplements. Commenting on the potential mechanisms of action for improving insulin sensitivity and glucose tolerance, the authors noted several possibilities including carboxylation of vitamin k-dependent protein, regulation of adipokine levels, anti-inflammatory activity, and lipid lowering effects. Further investigations are necessary to examine the role of other vitamin k-dependent proteins (E.
Although circulating dp-ucmgp was correlated to various markers of vitamin k status, no association with measures of coronary artery calcification were found. They concluded that mk4 supplementation at 600 ug/day or more was important in terms of the vitamin k requirements for bone health. Both vitamin k1 and vitamin k2 are also available in supplement form and often consumed in large doses.