Product name: Dr. Mercola, Vitamin K2, 180 mcg, 30 Capsules
Quantity: 30 Count, 0.12 kg, 8.9 x 4.8 x 5.1 cm
Categories: Dr. Mercola, Supplements, Vitamins, Vitamin K, Soy Free
Dietary Supplement, Soy Free, Dr. Mercola has been providing quality products since 2001.
Quickly and easy look up evidence on over 400 supplements across over 500 different health goals, outcomes, conditions, and more. 24 Additionally, subclinical vitamin k deficiency is not uncommon, especially in patients receiving warfarin. Research results suggest that the use of vitamin k is potentially beneficial in attenuating the progression of vascular calcification and several outcome trials are currently underway. Sufficient quantities of vitamin k in the body are necessary for the activation of these proteins in the body to take place, which then allows the proteins to bind calcium, and to move it around, and to function as an essential regulator of calcium and magnesium metabolism within the body, and specifically in bones, the heart, the arteries, the kidneys, teeth, etc. It is important to expand the knowledge base regarding the health effects of menaquinones and the distribution of mks in the food supply. Coli, as facultative anaerobes, can carry out both aerobic respiration and menaquinone-mediated anaerobic respiration. There are different types of vitamin k2, and the differences are reflected in the number next to the k. The concentrations of k-1 and k-2 vary, depending on the supplement. Most people are not deficient in vitamin k and symptomatic deficiency is rare, so unless you have a malabsorption condition or are severely malnourished, you likely get sufficient vitamin k from your diet (E. It appears that not having enough vitamin k is associated with, if not predictive, of certain types of death.
Dr. Mercola, Vitamin K2, 180 mcg, 30 Capsules: Vitamin K, Vitamins, Supplements
You should take an adequate amount of vitamin k2 to ensure that the vitamin d3 functions properly, and also to prevent arterial hardening which results from the improper depositing of calcium. Until a few years ago, it was believed that the only difference between vitamin k1 and vitamin k2 was their respective origina, and that the body was easily able to transform phylloquinone into menaquinone. But all this is somewhat irrelevant because this form of caramel color is not used by the supplement industry for making capsule shells. Large doses of vitamin a and vitamin e have been found to antagonize vitamin k. It is also not recommended for women who are pregnant or breastfeeding to take this supplement without medical supervision. Vitamin k2 can be further divided into several different subtypes, the most important ones being mk-4 and mk-7, summary vitamin k was initially discovered as a nutrient involved in blood clotting. I’m considering taking vitamin k for my bones, but i take blood thinner (Anti-coagulant) medication. In these observational studies, intake of vitamin k1 had no effect on outcomes. All but 2 trials used menaquinone-4, with the remainder using phytonadione supplements. The following groups are among those most likely to have inadequate vitamin k status. Matrix gamma-carboxyglutamate (Gla) protein (Mgp) is a vitamin k-dependent protein and a strong inhibitor of vascular calcification.
Dietary intake and adequacy of vitamin k. Plasma phylloquinone (Vitamin k 1) concentration and it’s relationship to intake in a national sample of british elderly people. 34 Thus, if further trials are performed, vitamin k 1 and k 2 should be tested. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect. In general, the vitamin k1 found in plants is poorly absorbed by the body. 2 Worldwide, the food richest in vitamin k2 is soybeans fermented with the bacterium bacillus subtilis. Determination of phylloquinone and menaquinones in food. Controversies concerning vitamin k and the newborn. Gla-containing proteins (Mgp and osteocalcin) regulate many anticalcification and bone-forming processes in the body, which are dependent on vitamin k in order to be produced. Q: Does vitamin k2 interact with vitamin d3? A second japanese study found that vitamin k intake, especially mk-7, was inversely correlated with fracture risk in men and women. K2 works in tandem with d3, and vitamin a. The recommended adequate intake for vitamin k depends on age and gender.
This could be further mediated by the combined use of vitamin d derivatives and warfarin. Although vitamin k is a fat-soluble vitamin, the body stores very small amounts that are rapidly depleted without regular dietary intake. However, this use of both calcium and vitamin d, while being possibly protective for bone disease, may aggravate vascular calcification. Vitamin k2 (Menaquinone) is produced by bacteria in both animal and human intestines. Role of vitamin k2 in the development of hepatocellular carcinoma in women with viral cirrhosis of the liver. Certain oral anticoagulants, such as warfarin, are known to be antagonists of vitamin k (See coagulation). 37 In another 3-year, double-blind, placebo-controlled trial, vitamin d and vitamin k were investigated. Food and dietary supplement labeling purposes, the amount in a serving is expressed as a percentage of daily value (%Dv). In the past few decades, vitamin k has emerged from a single-function haemostasis vitamin to a multi-function vitamin. People who are struggling to control their levels of blood sugar should be very careful with this supplement, which can cause an expected reduction of glucose levels. The problem is that vitamin k1 obtained from fresh vegetables is very poorly absorbed. Conversion of dietary phylloquinone to tissue menaquinone-4 in rats is not dependent on gut bacteria.
Aside from silica as a binder and filler, the supplement design is fairly clean, though not the best. Active 1,25-dihydroxyvitamin d enhances absorption of intestinal calcium and phosphate thus contributing to the regulating of mineral balance (43, 44). There are two main forms of vitamin k: Phylloquinone, also known as phytonadione, (Vitamin k1) which is found in green leafy vegetables such as lettuce, broccoli and spinach, and makes up about 90% of the vitamin k in a typical western diet; and menaquinones (Vitamins k2), which make up about 10% of western vitamin k consumption and can be synthesized in the gut by microflora. Beyond just the dose, we also looked at how the supplemental vitamin k2 was delivered. Although allergic reaction is possible, there is no known toxicity associated with high doses (Dietary or supplemental) of the phylloquinone (Vitamin k 1) or menaquinone (Vitamin k 2) forms of vitamin k. D3 helps your body absorb the all-important calcium, and vitamin k2 (As mk-7, the form of k2 with the highest bioavailability) directs the calcium to your bones instead of your joints and arteries, where too much calcium could be problematic. Newborns normally receive a vitamin k injection to protect them from bleeding in the skull, which could be fatal. Make sure your d3 levels are optimal and get at least 400 mg of magnesium via supplements every day.
Dr. Mercola Vitamin K
This paper should be used to support future research programs to further confirm and explore the vitamin k effects for risk reductions for developing diseases, and also identifying diseases where vitamin k could be the preferred action over a drug. This can prsent a problem for vegans and vegetarians, who need to expose themselves to direct sunlight for 30 minutes every day, if they want to raise their vitamin d3 reserves to appropriate levels. For example, the incidence of vertebral fractures was inversely correlated with lumbar bmd and plasma phylloquinone in a four-year prospective study that included 379 japanese women ages 30-88 years. Both forms of vitamin k are essential for blood clotting and bone health. 11, 12 Low vitamin k consumption or impaired vitamin k status is associated with a higher risk of hip fracture among older women 13, 14 and men, 14 lower bone mass in older women 15, 16 and men, 16 and increased bone turnover in girls. Effect of alpha-tocopherol and alpha-tocopherolquinone on vitamin k-dependent carboxylation in the rat. The mk-4 form of vitamin k 2 is produced by conversion of vitamin k 1 in the testes, pancreas, and arterial walls. The vitamin d3 form is three times more effective than the d2 and has less in the way of side effects than vitamin d3! Thirteen trials were included in the systematic review, and 12 showed that supplementation with either phytonadione or mk-4 improved bone mineral density. To date, calcium supplements are the most commonly used non-prescription drug to treat age-related bone loss.
Molecular basis of vitamin k-dependent gamma-carboxylation. A triage perspective reinforces recommendations of some experts that much of the population and warfarin/coumadin patients may not receive sufficient vitamin k for optimal function of vitamin k dependent proteins that are important for maintain long-term health. Thus, unless you are an institutionalised postmenopausal woman or you have already experienced a fracture, the uspstf does not recommend calcium and vitamin d for preventing a first-time fracture, as there is a lack of evidence. Beyond bone health and heart health, there are a few special groups who are particularly prone to vitamin k2 deficiency. Sports research makes a high-quality vitamin k2 supplement that uses the proprietary chickpea extract mk-7 as it’s source for the vitamin. Substantially different from calcium from dietary sources, calcium form supplements induce an acute rise in serum calcium levels that highly oscillates in blood for up to 6 h (15, 16). Worldwide, a large group of people is prescribed to a supplemental regime of both vitamin d and calcium. Structural differences in the different types of vitamin k govern many facts of metabolism of k vitamins including the way they are transported, taken up by target tissues and subsequently excreted.
Although there are no known toxicities, further research is needed before specific recommendations for supplements can be given. Dietary induced subclinical vitamin k deficiency in normal human subjects. The key difference between vitamin d2 and d3 is their origin. Vitamin k2 is one form of vitamin k, a relatively recently discovered vitamin that contributes to bone strength, blood clotting, and cardiovascular health. 896 Healthy volunteers and defined target groups for vitamin k supplementation had markers of vitamin k sufficiency measured in the blood, i. The vitamin k2 content for 3,5 ounces (100 Grams) of several foods is listed below (4, 5, 6). We propose a new hypothesis that if vitamin d concentrations are constantly high, there might not be enough vitamin k for activation of vitamin k-dependent proteins. In the case of vitamin k2, there are numerous isoforms (Or molecular variants) available for use as a food supplement.