Product name: Kirkman Labs, Alpha Ketoglutaric Acid, 300 mg, 100 Capsules
Quantity: 100 Count, 0.07 kg, 9.4 x 4.3 x 4.3 cm
Categories: Kirkman Labs, Supplements, Amino Acids, AAKG Arginine Alpha-Ketoglutarate, Condition Specific Formulas, Gluten Free, Hypoallergenic
Ultra Tested, Tested for More Than 950 Contaminants! Heavy Metals- Bacteria- Yeast- Mold- Pesticides and More, Casein and Gluten Free, Hypoallergenic, Dietary Supplement, Kirkman’s Alpha-Ketoglutaric Acid is formulated especially for individuals with special requirements and sensitivities. This product is often recommended by physicians because it is a buffered product that doesn’t produce excess acidity, Alpha-ketoglutarate is the salt form of alpha-ketoglutaric acid that binds to other substances. For example, calcium alpha-ketoglutarate is alpha-ketoglutaric acid bound to calcium, By itself, alpha-ketoglutaric acid is a strong organic acid, and taking it by mouth can upset the stomach or irritate the esophagus. Kirkman has solved this problem by blending alpha-ketoglutaric acid with its calcium and magnesium salts to produce a “bi-element buffered alpha-ketoglutaric acid” that will not produce excess acidity, This nutrient can be taken with meals or away from meals. The hypoallergenic capsule can be swallowed or opened and the powder mixed with fruit juices or food. It has a pleasant, citrus-like taste.
It is important to understand how the supplement may interact with the body and with additional medications before taking it. It is a dietary supplement used mostly by athletic people because it is the amino acid that directly produces nitric oxide via the nitric oxide synthase enzymes. The human body requires arginine for various functions, but it is most important for eliminating ammonia, which is toxic to the human body, by controlling the urea cycle. L-arginine also stimulates the secretion of growth hormone. The purpose of this study was to examine the effect of creatine supplementation on the cognitive performance of elderly people. No Platinum increased plasma l-arginine levels; however, the effects observed in hemodynamics, brachial-artery blood flow, and nox can only be attributed to the resistance exercise. Recommended usage: As a dietary supplement, take 2 servings daily on an empty stomach.
Kirkman Labs, Alpha Ketoglutaric Acid, 300 mg, 100 Capsules: Condition Specific Formulas, AAKG Arginine a-Ketoglutarate, Amino Acids, Supplements
A sample size analysis was performed and showed that at least eight subjects were required in each group to achieve a power of 0,80, data for 1rm and tlv between aakg and placebo were analyzed using a 2 (Condition; aakg or placebo) x 2 (Status; untrained or trained) repeated measures analysis of variance (Anova) followed by an independent t-test when the 2 x 2 anova resulted in significant difference. Due to it’s mild taste, people recommend consuming aakg with a juice or smoothie. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect. Although there is limited evidence that the combination of arginine alpha-ketoglutarate has health benefits, the individual molecules l-arginine and alpha-ketoglutarate have been researched for their health benefits. However, l-arginine is often combined with other supplements, which have different results. Dietary supplements containing l-arginine are marketed to improve exercise performance, but the efficacy of such supplements is not clear. Aakg stands for arginine alpha-ketoglutarate. Also in this year, a group of italian scientists discovered that arginine helped reduce blood pressure in their patients. L-arginine has some potential side effects to be aware of when taking it as a supplement. There is insufficient evidence to support the use of l-arginine for any of the below listed uses. I have found an effective dose of this supplement to provide an increase in muscle pumps is 4 grams or 2 scoops of this version 30-40 minutes pre workout.
Aakg is a popular supplement among bodybuilders and other athletes because of claims that it increases production of nitric oxide in muscles. Several animal studies indicate that supplementation with l-arginine may be an effective way to improve blood vessel function in diabetes. Users and supplement manufacturers have established unofficial doses based on trial and error. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Take one hour before bedtime as a food supplement or as directed by a healthcare professional. This amino acid should never be used as a replacement for approved medical therapies. In addition to building protein, l-arginine releases nitric oxide in the blood. While supplementing, all groups participated in a periodized resistance training program performing the same relative load and volume of training regardless of their assigned experimental group.
However, in the current study, acute aakg supplementation provided no ergogenic benefit, regardless of the subjects training status. Our results indicate an improvement in the muscular resistance capacity to fatigue following the treatment by oral administration of arginine. If you experience an adverse reaction, stop taking the supplement and seek medical advice. Upon clearance and following a 5 minute rest, the participant ingested either a serving of commercially available aakg (Healthwatchers de inc, bohemia, ny) or a placebo composed of microcrystalline cellulose (Apotheca inc, woodbine, ia) with 300ml of water. Unlike l- form amino acids, akgs are shuttled directly to the muscle cells rather than being absorbed and used by the small intestines for nucleotide synthesis. Aakg 1:1 (L-arginine alpha ketoglutarate 1:1) Is the combination salt form of l-arginine and alpha ketoglutaric acid at the molecular ratio of 1:1, With weight ratio 54,38% l-arginine base, and 45,63% alpha ketoglutaric acid. This product contains 100% arginine-alpha-ketoglutarate in it’s purest form to give you continuous pumps and rock hard muscles. In these cases, people may be prescribed artificial l-arginine in the form of oral medication, injections, or creams.
To improve absorption in the stomach, alpha-ketoglutarate supplements come in the form of various salts. The ergogenic benefits of arginine-based supplementation remain equivocal in the literature. If using any pharmaceuticals or drugs given to you by a doctor or received with a prescription, you must consult with the doctor in question or an equally qualified health care professional prior to using any nutritional supplementation. A number of properly controlled clinical investigations have proved that 2g of arginine given to sportspeople over a period of 5 weeks, results in a substantial (In comparison to the control group) strength increase and growth of lean muscular mass, as well as a reduction of fat and protein decomposition products. If you want an arginine supplement that is clean, has no taste, and works fabulously, look no further. Anyone considering supplementing with arginine who suffers with existing heart or psychiatric conditions please consult your doctor prior to supplementing with any arginine-based products. What does 100% aakg amino acid work well with? Alpha-ketoglutarate (Akg) is the deaminated carbon skeleton of the amino acid glutamic acid.
Kirkman Labs AAKG Arginine a-Ketoglutarate Condition Specific Formulas
Patients with herpes infections should take l-arginine with caution, as it may aggravate the virus and increase symptoms. During normal protein turnover or when you take in a lot of protein, alpha ketoglutarate takes on nitrogen from amino acids, turning into glutamate. In this reaction, arginine is transformed into gas hormone – nitric oxide (No). If you are taking lysine, we do not recommend taking l-arginine, which will cancel out the beneficial effects of lysine and vice versa. Arginine alpha-ketoglutarate is a dietary supplement made up of the amino acid arginine and compound alpha-ketoglutarate. Quickly and easy look up evidence on over 400 supplements across over 500 different health goals, outcomes, conditions, and more. Excitatory amino acid transporter (Eaat)-2 is one of the major glutamate transporters expressed predominantly in astroglial cells and is responsible for 90% of total glutamate uptake. This improvement may be seen immediately after consuming arginine. I l-glutamine is an amino acid whose amount is the highest in human muscle and plasma accounting for approximately 60% of total free amino acids in a body And is the major source of energy in intestinal mucosal cells, fibroblasts, lymphocytes, and macrophages.
Akg drives the amino acid into muscle cells creating a pro-muscle growth environment. People doing weight training reported relief from muscle pain when taking arginine alpha-ketoglutarate. Data for hr were analyzed by using a 2 (Condition; aakg or placebo) x 3 (Time; pre, post upper, post lower) repeated measures anova, followed by paired t-test when the 2 x 3 anova resulted in significant difference. In an eight-week double-blind trial, weight lifters taking 4 grams of aakg three times a day reported no significant side effects, showed no changes in blood pressure or heart rate, and had no abnormalities on standard blood tests for general health. 5 Some doctors believe that people with herpes (Either cold sores or genital herpes) should not take arginine supplements, because of the possibility that arginine might stimulate replication of the virus. L-arginine has two effects: It turns into nitric oxide and helps the body build protein. Although l-arginine is considered safe in moderate doses, too much l-arginine can have severe side effects, including death. What vegan and vegetarian alternatives to aakg do you offer?
To maintain elevated arginine levels throughout the day, arginine can be taken up to three times a day, with a combined dose total of 15-18g. Ingredients: L-arginine alpha ketoglutarate, bulking agent: Microcrystalline cellulose, stabilizer: Hydroxy-propyl-methylcellulose; anti-caking agents: Magnesium salts of fatty acids, silicon dioxide. While the present findings reflect this relationship, hr values were not significantly different between subjects that ingested aakg or placebo. I would recommend going for this as a decent pump promoting compound that i find to be great to improve the quality of a range of workouts for anyone who is after a non stimulant supplement to use pre workout due to not getting on too well with caffeine or being in a stimulant break phase. Preliminary evidence suggests that arginine may be useful in the treatment of medical conditions that are improved by vasodilation, such as angina, atherosclerosis, coronary artery disease, heart failure, intermittent claudication/peripheral vascular disease, and vascular headache. Note: L-citrulline supplementation is more effective at maintaining elevated arginine levels for long periods of time. In muscular tissue, cyclic nucleotides take part in blood circulation and oxygen, amino acids, creatine and energy elements distribution, as well as in generating strength impulses and protein anabolism. Of note, although most supplements appear to be safe when consumed at typical doses, some adverse events have been reported for some of them (E.
Purebulk’s supplements are tested by accredited third party labs in the usa to ensure their identity, purity and potency. Taking arginine in capsule form is not recommended because it would take upwards of 20 capsules per serving to have a substantial impact on gh, which is why powder is the recommended delivery method. Scientifically formulated to give you more energy, strength, and stamina during every workout, zhou nutrition nitric oxide supplement helps you pump like a pro and maximize your results. I am combining arginine with beta alanine and 200 mgrms of caffeine to make a preworkout solution. This report provides estimates of dietary supplement use for specific population groups over time. Research-based evidence to support the use of arginine alpha-ketoglutarate to increase strength and improve exercise performance is limited and not conclusive. Studies suggest that aakg may effectively help the liver neutralize ammonia and other harmful substances, which should make for less pain, less muscle fatigue, and longer workouts. To receive a copy of these test results or any other purebulk supplement please fill out the coa request form found here. The amino groups of amino acids are attached to alpha-ketoglutarate via transamination reactions, where it is then carried to the liver where the urea cycle takes place. L-arginine is a conditionally essential amino acid. The l-arg supplementation alone did not impair renal fibrosis and renal function.
The amino-acid supplement and placebo were given twice/day for 6 weeks. There have been 3 reported hospitalizations associated with arginine alpha-ketoglutarate supplementations.