LifeTime Vitamins, Milk Thistle Extract, 250 mg, 60 Capsules

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Product name: LifeTime Vitamins, Milk Thistle Extract, 250 mg, 60 Capsules
Quantity: 60 Count, 0.16 kg, 5.6 x 9.9 x 5.6 cm
Categories: LifeTime Vitamins, Herbs, Homeopathy, Milk Thistle Silymarin

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In follow-up, silymarin use was associated with reduced progression of fibrosis to cirrhosis but without an impact on clinical outcome. Because it acts on the liver, milk thistle can theoretically interact with several medications that are processed through the liver. Patients either had the silymarin gel or a placebo gel starting on the first day of radiotherapy treatment and continuing for the full 5 weeks of treatment. This indicates that silymarin has anti-inflammatory and antiviral effects in patients with chronic hepatitis c. Based on safety and their multiple targeting actions, herbal therapies are potent therapeutic means in t2d. Milk thistle preparations are usually standardized to a concentration of 70 to 80% of three flavonolignans (Silibinin, silychristin, and silydianin), collectively known as silymarin. Further research on humans is needed to identify what benefits a person can expect from applying milk thistle to their skin. Its herbal remedy is known as milk thistle extract. Raloxifene: Coadministration of milk thistle and raloxifene may lead to 4- to 5-fold increases in raloxifene systemic exposure due to inhibition of intestinal glucuronidation by silybin a and silybin b. Herbal and complementary and alternative medicine therapies for liver disease. For these reasons, you should take herbs with extreme care, and only under the supervision of your doctor. The potential health benefits of milk thistle are explored below.

LifeTime Vitamins, Milk Thistle Extract, 250 mg, 60 Capsules: Milk Thistle Silymarin, Homeopathy, Herbs

Human research studies have shown that it is more effective to administer this herb in three or four small portions over the day than in one large daily dose. Of the 170 patients, 87 received 420 mg of silymarin daily, compared with 83 placebo patients. Oral consumption of milk thistle (Standardized to 70% to 80% silymarin) at 420 mg/day is considered safe for up to 41 months based on clinical trial data. These studies have also seen that milk thistle may be able to reduce the number of amyloid plaques in the brains of animals with alzheimer’s disease (18, 19, 20). The ancient greek and romans used milk thistle for snake bites. In a study of patients with liver cirrhosis, silymarin did not exert protective effects against contrast-induced nephrotoxicity. However, studies are mixed as to whether milk thistle improves liver function tests or quality of life for people with chronic active hepatitis b or c. Ten randomized trials have been reported in patients with hepatitis or cirrhosis, and one randomized trial has reported the use of silymarin as a prophylaxis to iatrogenic hepatic toxicity. A dose of 140 mg of silymarin 3 times daily has been suggested for hepatic cirrhosis. The median time to toxicity was prolonged significantly with the silymarin-based cream (45 Vs. Gaertner pharmacopeial name: Cardui mariae fructus other names: Blessed milk thistle, st. Poisoning suggests that silymarin has been shown to be an effective drug in the treatment of this mushroom poisoning.

The major constituents of silymarin are the three diastereomeric pairs, silybins a and b (Also called silibinin), isosilybins a and b, silychristin, isosilychristin, and silydianin. (B) the selected plants and compounds exert their antihyperglycemic effect through targeting one single mechanism (Insulin resistance (Type 1 herbs), -cell function (Type 2 herbs), glp-1 (Type 3 herbs), or glucose (Re)absorption (Type 4 herbs)) or multiple mechanisms. An early study from finland found that a four-week course of silymarin supplements lowered key liver enzymes in people with subacute disease, suggesting the liver was functioning more normally. They are seen in very high numbers in the brains of people with alzheimer’s disease, meaning that milk thistle could potentially be used to help treat this difficult condition. Cordyceps (Cordyceps sinensis): Is a type of mushroom used in traditional chinese medicine to support the liver. Only at very high concentrations was cell viability affected by silymarin in hepg2 cells. In vitro studies show that silymarin decreases the components of the cytochrome p450 enzyme system, which is involved in the clearance of certain chemotherapy drugs. In the eclectic medicine movement (19Th to 20th century), milk thistle was used to treat varicose veins, menstrual difficulty, and congestion in the liver, spleen, and kidneys.

Rare cases of milk thistle producing a laxative effect have been reported. The herb has been used since greco-roman times to treat liver problems. All symptoms resolved when the silymarin was discontinued. Ginger, zingiber officinale, is commonly used as an ingredient in foods and medicine. Most clinical trials have investigated silymarin’s effectiveness in the treatment of patients with hepatitis, cirrhosis, or biliary disorders. In a pilot, randomized, double-blind, placebo-controlled clinical trial, hospitalized patients receiving cisplatin were administered placebo or oral silymarin 420 mg/day in 3 divided doses starting 1 to 2 days prior to cisplatin initiation and continuing through the end of 3 cycles of 21-day chemotherapy. At present, there is not enough scientific data to say whether milk thistle can help the liver or not. The best way to prevent the complications is to ensure that these medicines be given only by physicians who are licensed and certified. Here are 7 science-based benefits of milk thistle. Summary the active ingredients in milk thistle have been shown in animals to improve the effects of some cancer treatments. Mucositis scores (World health organization, national cancer institute common toxicity criteria) were significantly lower in the silymarin group.

Pharmacologically effective substance of silymarin includes four main ingredients: Silybin, silychristin, silydianin, and isosilybin. In a study of rats receiving ethanol during specific weeks of the gestational period, coadministration of silymarin with ethanol resulted in no deficits in spatial working memory in rats on postnatal day 60, suggesting silymarin provided a protective effect against alcohol-induced learning issues. They suggest that a substance in milk thistle (Silymarin) can protect the liver from damage caused by viruses, toxins, alcohol, and certain drugs such as acetaminophen (Tylenol). In traditional chinese medicine, milk thistle is referred to as da ji, while the seeds are called shui fei ji. G, dry extract noted below) equivalent to 200-400 mg per day of silymarin, calculated as silibinin. Summary initial test-tube and animal studies have shown that milk thistle has some promising characteristics that could make it useful for protecting brain function. Nature is an extraordinary source of antidiabetic medicines. Agency for healthcare research and quality (Ahrq), milk thistle improved liver function in people with mild liver disease, but was less effective for those with severe liver disease, such as cirrhosis.

LifeTime Vitamins Milk Thistle Silymarin

Intense research activity has been dedicated to the identification of natural products from traditional medicine that regulate abca1 expression. But now more evidence has come in: In a careful, double-blinded study financed by the national institutes of health, researchers at the university of north carolina found that milk thistle had no real effect on people with chronic hepatitis c. The hepatoprotective activity of s5 was similar to the standard hepatoprotective drug silymarin and livome effects are more significant than the standard hepatoprotective drug silymarin. Ingredients: Grain alcohol (67-77%), Distilled water and milk thistle extractives. Several small studies have investigated silymarin for it’s direct treatment of cancer or for it’s effects on treatment-related toxicity. Neopterin, a marker of cellular immune system activation, and tnf-alpha were decreased in both groups after silymarin therapy, whereas production of interferon-gamma and il-4 were increased. A formula composed of two or more drugs has been demonstrated as more beneficial for disease treatment, but the selection of individual herbs in the formula must be strictly guided by the principles underlying chinese herbal medicine.

In a clinical trial of patients with prostate cancer and rising prostate-specific antigen (Psa) levels following radical prostatectomy or radiotherapy, a dietary supplement containing silymarin, soy, isoflavones, lycopene, and antioxidants delayed psa progression; however, because the product contained several ingredients, outcomes cannot be attributed to any single ingredient. The commission e approved the internal use of crude milk thistle fruit preparations for dyspeptic complaints. The active ingredient in milk thistle can help to reduce inflammation. This article highlights the current practice and recommended improvement of natural medicines in the treatment of liver diseases and gives some specific examples to emphasize the prevention and management of adverse reactions of the natural agents and suggests that natural medicine should be cautiously used to treat liver problems. Complementary medicine, self-help, and lifestyle interventions for obsessive-compulsive disorder and the ocd spectrum: A systematic review. A drop of mary’s milk fell, causing the distinctive white veins on the leaves of milk thistle. Herbs, like medications, contain active substances that can trigger side effects and interact with other herbs, supplements, or medications. More than 60 natural compounds from traditional medicine, especially traditional chinese medicine (Tcm), are reported to regulate abca1 expression in different in vitro and in vivo models (Such as cholesterol efflux and atherosclerotic animal models).

Most clinical trials of milk thistle have been conducted in patients with either hepatitis or cirrhosis. Natural products from traditional medicine constitute a large promising pool for compounds that regulate abca1 expression, and thus may prevent/treat diseases related to cholesterol metabolism, like atherosclerosis or alzheimer’s disease. Silybin and silymarin have been studied in the treatment of aging skin and rosacea, as well as in skin cancer prevention. Rats and dogs have received silymarin at doses of 50 to 2,500 mg/kg of body weight for a 12-month period. Our ultimate herbal detox program has a specific range of herbs designed to specifically detox your liver. Call 911 or seek emergency care if you experience shortness of breath, rash, hives, rapid heartbeat, lightheadedness, or swelling of the face, tongue, or neck after taking milk thistle. These findings suggest that silymarin plays a prominent role in the reduction of cancer cells and in preventing the formation of cancer cells. For an explanation of the scores and additional information about levels of evidence analysis of cam treatments for cancer, refer to levels of evidence for human studies of integrative, alternative, and complementary therapies. Pregnant or breastfeeding women should not use milk thistle or licorice. In the world of alternative medicine, milk thistle is the treatment of choice for liver disease, particularly chronic infection with hepatitis c. Some forms of hepatitis have responded to silymarin treatment.

There is mixed data regarding milk thistle’s ability to exert inhibitory or inductive activity on cyp1a2, 2c19, 2d6, 2e1, and 3a4, as well as p-glycoprotein. Milk thistle has poor oral availability, and as such, phospholipid complexes of silibinin and silymarin help improve absorption. Native americans use milk thistle to treat boils and other skin diseases.