Natural Factors, Pycnogenol, 25 mg, 60 Vegetarian Capsules

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Product name: Natural Factors, Pycnogenol, 25 mg, 60 Vegetarian Capsules
Quantity: 60 Count, 0.05 kg, 5.6 x 5.6 x 9.9 cm
Categories: Natural Factors, Supplements, Antioxidants, Pine Bark Extract, Pycnogenol, Non Gmo, Vegetarian, Vegan

Dietary Supplement, French Maritime Pine Bark Extract, Healthy Aging, Isura – Non-GMO – Mass-Spec – Documentation – Lab Tested, Suitbale for Vegetarians / Vegans, Pycnogenol French maritime pine bark extract is extracted from the bark of pine trees (Pinus pinaster) grown exclusively in Les Landes de Gascogne forest in southwest France near the famous Bordeaux region. The forest is an unspoiled and natural plantation with no pesticides and no herbicides. May help provide support for healthy joint function and maintenance. May support natural inflammation transition from acute to resolution state. Helps reduce (climacteric) symptoms associated with peri-menopause including hot flushes, restlessness (difficulty falling asleep), and poor mental concentration and focus. Helps support cognitive health in an aging population (>60 years of age). Provides antioxidants for the maintenance of good health.

These data suggest that interactions between the major constituents of this supplement combination are unlikely and therefore could be investigated to manage patients with osteoarthritis without significant concerns for possible pharmacokinetic interactions. This is how i know that this product works as well as branded pycnogenol because i truly felt the difference without it. In rodent studies, pine bark extract showed antioxidant effects and improved insulin resistance and hyperglycemia. All five studies reported subjective improvements in cvi-related symptoms in the pycnogenol treatment groups. The aim of this study was to explore in a pilot trial whether supplementation with french maritime pine bark extract pycnogenol could alleviate side effects and improve patient’s quality of life. A study of 58 patients with hypertension showed that 100 mg of pycnogenol daily had a positive effect on their blood pressure. 9 By administering a combined daily dose of pine bark extract, 480 mg, and vitamin c, 240 mg, to 24 healthy subjects in an open-label preevaluation and postevaluation, shand et al 12 found a significant decrease of 7 mm hg in the mean systolic blood pressure at 6 weeks, with a sustained decrease at 12 weeks. Results of recent studies also suggest that pine bark extract may have additional cardiovascular benefits, including enhanced glycemic metabolism, 8, 9 reduced body weight, 12 and improved lipid profile.

Natural Factors, Pycnogenol, 25 mg, 60 Vegetarian Capsules: Pycnogenol, Pine Bark Extract, Antioxidants, Supplements

I’ve been taking pine bark (Pycnogenol) since the 90S to help me manage my adhd and nothing is more powerful and helping me concentrate and alleviate many of the negative symptoms of adhd. In addition to the antioxidant activity, pycnogenol enhances production of vasodilatory endothelial nitric oxide and prostacyclin. Is a powerful super-antioxidant shown in decades of research to boost blood circulation and act as a natural anti-inflammatory. After three months, about 45 percent of those who took pycnogenol were completely asymptomatic compared to 23 percent of controls. Stay with viva’s pine bark from les landes de gascogne forest in southwestern france. Even though the health effect of pine extract has been well studied, there is little understanding about the detailed mechanism. In this study, the antioxidant activity of several phytochemicals was compared using two different antioxidant assays: The oxygen radical absorbance capacity (Orac) assay, which measures the decrease in fluorescence decay caused by antioxidants, and the total oxyradical scavenging capacity (Tosc) assay, which measures the decrease in ethylene production caused by antioxidants. There are limited clinical data showing pine bark extract can be used together with standard blood pressure medication. There are several sources for pycnogenol, but this one if from the original and from my experience, the most potent.

By becoming an examine plus member, you will have access to all of the latest nutrition research on over 300 supplements across over 500 different health goals, outcomes, conditions, and more. Pyc antagonizes the vasoconstriction caused by epinephrine and norepinephrine by increasing the activity of endothelial nitric oxide synthase. Toyo shinyaku co, ltd provided study tablets (Toyo-fvg pine bark extract and placebo). Pyc also participates in the cellular antioxidant network as indicated by it’s ability to regenerate the ascorbyl radical and to protect endogenous vitamin e and glutathione from oxidative stress. Pine bark extract is a supplement used for anti-aging and preventive care as well. This dosage was selected based on the midrange of administration in past studies and the opc content of this pine bark extract compared with other formulations. Of japan, which provided the pine-bark extract along with the placebo tablets. Children who took a pycnogenol supplement for one month had healthy antioxidant levels. Pycnogenol (Pyc) is a standardized extract composed of a mixture of flavonoids, mainly procyandins and phenolic acids. A recent study showed that pycnogenol can offer protection from the free radicals that come from the harmful rays of the sun (Photoprotection) and may also reduce hyperpigmentation of the skin, improve the skin barrier function and extracellular matrix homeostasis (The maintenance of the structure of cells and soft tissues).

In this study, we investigated the anti-tumor effects of pycnogenol on hl-60, u937 and k562 human leukemia cell lines. Compelling data from a preliminary clinical trial conducted in germany has shown improved skin elasticity and skin hydration in post-menopausal women taking just 75 mg of pycnogenol for 12 weeks. A new study from the stanford university school of medicine shows that pine-bark extract had no effect in lowering blood pressure or reducing other risk factors for heart disease. According to the makers of pycnogenol, the extract has four basic properties. The strength of this study is that it is the first meta-analysis to assess the potential role of arginine supplements in ed compared with placebo or no treatment. The free radical generated from the oxidation of a french maritima pine bark extract pycnogenol (Pyc), by the horseradish peroxidase (Hrp)-hydrogen peroxide (H2o2) system at ph 7,4-10,0 was studied using electron spin resonance (Esr) spectrometer. Antidiabetic effect of pycnogenol french maritime pine bark extract in patients with diabetes type ii. Various pharmacological effects of pcos have been reported, such as antioxidant and radical scavenging activities, reduction of capillary permeability and fragility, inhibition of destruction of collagen, and reduction of inflammation. Radiata are medium-sized pines growing up to 30 m tall with bright red-brown, deeply fissured bark. In conclusion, pycnogenol was found to be more efficacious than venostasin for the treatment of cvi.

It was recently shown that pycnogenol (Pyc; a proprietary mixture of water-soluble bioflavonoids extracted from french maritime pine bark) was selectively toxic to established malignant ovarian germ cells. Histological sections of the intestines showed a dramatically better condition of the mucosal layers compared with the irradiated control animals administered water without pycnogenol. Conclusions this pine bark extract (At a dosage of 200 mg/d) was safe but was not associated with improvement in cardiovascular disease risk factors. In a trial of 60 children with asthma, 16 out of the 30 in the treatment group were able to stop using their inhaler after taking 1 mg of pycnogenol for 3 months. Diabetic group pyc treated group pyc treated diabetic group recommendation and dosages can vary between supplements. It is pricey, but i am glad to continue taking both of these supplements. One study found pycnogenol is not effective in treating adhd in adults. Although traditional strategies such as prescription medications, dietary changes, and physical activity have proven benefits for reducing cardiovascular disease (Cvd) risk, a substantial population seeks alternative therapies, including various dietary supplements, to lower cvd risk. Anthocyanidin production and tannic acid equivalent (Tae) of extracts of species in which a and d type procyanidins have been reported to occur have been studied.

Natural Factors Pycnogenol

Essential oil composition and the amount of extracts (Lipophilic and hydrophilic) of maritime pine wood and fresh cone samples had been tested. The aim of this study is to investigate anticancer effect of pycnogenol in mc-3 human mucoepidermoid carcinoma (Mec) cell line. New research shows that adults over the age of 55, supplementing with pycnogenol over the course of one year, showed superior results in brain related tasks compared to placebo groups. Pine bark extract is available without a prescription in the us health food stores and pharmacies, as well as from online sources. While pycnogenol is a natural supplement, it can have powerful effects on your health, both positive and negative. Also chemical composition varies among dietary supplements, making standardized testing difficult. Supplements containing the french maritime pine bark extract pycnogenol may help protect against the effects of oxidative stress after exercise, says a new study with 20 healthy young men. Pine bark extract is generally recognized as safe (Gras) based on data from animal studies and clinical trials; however, few studies evaluate safety as a primary outcome. In the present study, we investigated whether pinus densiflora bark extract has potential to prevent cataract formation and elucidated the underlying mechanism. Pycnogenol is an extract of french maritime pine bark (Pinus pinaster) that consists of a concentrate of polyphenols, mainly procyanidins.

An increasing body of evidence indicates that pycnogenol (Pyc), a standardized extract of french maritime pine bark, has favorable pharmacological properties. A study of 53 college students, for instance, showed pycnogenol enhanced memory and focus leading to improved test scores. The extract has been used for anemia, inflammation, and cardiovascular conditions. Trials of pine bark extract have shown decreases in ldl-c level, 6, 23 while equal numbers of trials, including ours, reported no significant benefits of pine bark extract on ldl-c level. A study of 146 people suffering from a common cold found supplementing with pycnogenol was able to reduce the duration (I. Study results showed that 18 of the 24 participants who took pycnogenol had an improvement in their vision, while no such improvements were observed in those who took the placebo. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements.

27 Issue of the archives of internal medicine, is the largest randomized, placebo-controlled clinical trial to date examining the effects of pine-bark extract on blood pressure and other heart disease risks. The most important intracellular antioxidant in the human body is glutathione (Gsh). In an open, controlled comparative study 40 patients with diagnosed cvi were treated either with 600 mg chestnut seed extract per day or 360 mg pycnogenol per day over a period of 4 weeks. The low-dose buildup effect of pycnogenol as an antiinflammatory agent would make it useful in a multinutrient format, but it may not be the most potent antiinflammatory in isolation. Although a different dosage or formulation might produce different results, our findings argue against recommending this pine bark extract to improve cvd risk factors. The extract has been widely studied for the past 40 years and has more than 280 published studies and review articles ensuring safety and efficacy as an ingredient. A double blind, placebo-controlled study of 77 diabetic patients taking their prescription medications, along with 100mg of supplemental pycnogenol, found greater improvement in blood sugar control and cardiovascular health when pine bark extract was combined with diabetic medications. The primary hypothesis was that pine bark extract would lower blood pressure in a population of overweight and obese participants with baseline prehypertension or hypertension.

Arthritis and inflammation have also been improved in studies using pine bark extract, as well as the uncomfortable symptoms of pms and menopause. In another group of 19 american smokers, increased platelet aggregation was more significantly reduced by 200 than either 150 mg or 100 mg pycnogenol supplementation. The aim of this study was to compare the efficacy of venostasin (Horse chestnut seed extract) and pycnogenol (French maritime pine bark extract) in the treatment of chronic venous insufficiency (Cvi). Furthermore, pycnogenol significantly decreased cholesterol and ldl values in the blood, whereas hdl remained unaffected. Two of the studies supplemented subjects with 150 mg/day, while the latter used 100 mg/day. If undergoing medical therapies, then consult with your respective therapist or health care professional about possible interactions between your treatment, any pharmaceuticals or drugs being given, and possible nutritional supplements or practices hosted on examine. Many pine bark extracts on the market are not standardized and the concentration of active components and bioactivities are hard to determine. The mixed results suggest that pycnogenol blood-pressure lowering effects may be dependent on the underlying cause of hypertension.

Three-day food records were administered at baseline and at 12 weeks to monitor changes in diet, particularly intake of antioxidant-rich foods.