Product name: Natural Factors, Vitamin D3, 2000 IU, 120 Softgels
Quantity: 120 Count, 0.07 kg, 4.8 x 4.8 x 9.4 cm
Categories: Natural Factors, Supplements, Vitamins, Vitamin D, D3 Cholecalciferol, Non Gmo
Dietary Supplement, Supports Healthy Bones, Isura: Non-GMO- Mass Spec- Documentation – Lab Tested, Purity and Potency Guaranteed, Vitamin D3 is essential for strong bones and teeth as it increases the body’s absorption of calcium from food. Its role in regulating calcium levels also helps regulate the immune system and maintains healthy nerves and muscles. Vitamin D3 is carefully blended with organic flaxseed oil in an easy-to-swallow softgel, Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.
In some countries, staple foods are artificially fortified with vitamin d. An increasing number of biological studies in recent years have been focusing on the biochemical interaction between vitamin d and the gh/igf-1 axis in humans. Table 1 summarizes the 21 studies that provided information on serum 25(Oh)d or pth before and after vitamin d dosing compared to a control group. The best marker of vitamin d status is 25-(Oh)d, she says. You should not take more than 4,000 iu a day of vitamin d3 unless your doctor tells you otherwise. About four million australians now suffer from a vitamin d deficiency, according to the latest abs data. Although many trials have evaluated the influence of vitamin d supplementation on clinical outcomes and that use of vitamin d supplements is more widespread at older ages, few attempts have been made for evaluating the influence of variable doses of vitamin d supplementation on serum 25-hydroxyvitamin d levels in these older age groups (6, 7). Cholecalciferol supplementation alters gut function and improves digestibility in an underground inhabitant, the naked mole rat (Heterocephalus glaber), when fed on a carrot diet. Chemically, the various forms of vitamin d are secosteroids, i. Genetic contribution to bone metabolism, calcium excretion, and vitamin d and parathyroid hormone regulation.
Natural Factors, Vitamin D3, 2000 IU, 120 Softgels: D3 Cholecalciferol, Vitamin D, Vitamins, Supplements
In general, adults are advised to take a supplement containing 800 international units (20 Micrograms) of vitamin d per day to maintain a normal vitamin d level. Vitamin d doses in the range of 200,000 to 300,000 iu were associated with significantly lower plasma pth concentrations at 8 weeks in elderly adults (31, 35) And 24 weeks in vitamin d-deficient adults. Summary cod liver oil is the single best source of vitamin d3, fatty fish is also a good source, but you have to eat it frequently to get enough. 1,25(Oh) 2d, the active vitamin d form, binds to the vdr to increase intestinal calcium absorption and exert the other vitamin d-related actions. What are some symptoms of a vitamin d deficiency? Magnesium assists in the activation of vitamin d, which helps regulate calcium and phosphate homeostasis to influence the growth and maintenance of bones. The uk national health service recommends babies and young children aged six months to five years, pregnant or breastfeeding women, and sun-deprived elderly people should take daily vitamin supplements to ensure sufficient vitamin d intake. When the analysis was narrowed to those who were in the trial for at least two years, the researchers saw a 25 percent reduction in death from cancer with vitamin d. 1) Showed how the absolute increase in vitamin d status depended on the dose of supplement and also on the type of vitamin d, with vitamin d2 being less efficient than for increasing serum levels. Fish oil supplements offered some benefits, preventing heart attacks, but not stroke.
Sunlight and vitamin d for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. However, according to the model derived from the meta-regression, the increase obtained by the whi trial was about half the expected average increase based on randomized trials that reported the influence of vitamin d3 supplements on serum 25-hydroxyvitamin d concentration. The reason is thought to be because vitamin d is an oily substance that tends to get stored in the body’s fat tissue. But we found levels of lead in nine of 12 supplements that combine vitamin d with calcium that would have triggered warnings for reproductive risk under california proposition 65, however, a number of companies had reached a settlement with the california attorney general’s office that allows them latitude in how they count lead levels and in these cases the products do not have to have warnings. Of note, most experts recommend against direct sun exposure for children under the age of 6 months; for this demographic, vitamin d supplementation by itself is the best option. Evolutionary biology and pathology of vitamin d. Studies that evaluate the effects of gh on the other serum markers of bone function that are influenced by vitamin d (Ca, p, pth) in adults have yielded conflicting results. If you are only exposing your face and hands, you will produce much less vitamin d. Comparison of oral alendronate versus prednisolone in treatment of infants with vitamin d intoxication.
Pregnancy – low levels of vitamin d in pregnancy are associated with gestational diabetes, pre-eclampsia, and small (For gestational age) infants. Unlike cholecalciferol, which is typically only available as a maximum dose of 5,000 units per capsule or tablet, ergocalciferol is available as a monster 50,000 unit dose. I take one capsule every morning to top up my vitamin d as we approach winter. Studies are now testing whether adding various doses of vitamin d to regular treatments can help people with ms. In a clinical setting, vitamin d (In combination with calcium) is most often used to treat and reverse conditions resulting in thin, brittle, and fragile bones: Rickets in children, ostemalacia in adults, and osteoporosis in older adults. Three of four studies failed to show pth lowering using 200,000 to 300,000 iu vitamin d 2 (31, 33, 43); Only yu et al Showed a significant decrease in pth in pregnant women at delivery, following administration of 200,000 iu of vitamin d in the 27th week of pregnancy. Depression – clinical trials of vitamin d supplementation for depressive symptoms have generally been of low quality and show no overall effect, although subgroup analysis showed supplementation for participants with clinically significant depressive symptoms or depressive disorder had a moderate effect. More homogeneous results come from pediatric studies: Of the four studies that considered the effect of vitamin d supplementation on igf-1 levels, all showed a positive correlation between these two parameters.
Summary evidence suggests that vitamin d works with magnesium and vitamins a and k to promote health. Photobiology of vitamin d in mushrooms and it’s bioavailability in humans. The evidence for other health effects of vitamin d supplementation in the general population is inconsistent. And other countries, cow’s milk and plant-derived milk substitutes are fortified with vitamin d, as are many breakfast cereals. Further research is, therefore, necessary to confirm the protective effect of vitamin d on the flu. Vitamin d3 (Cholecalciferol) for vitamin d deficiency: After my wellness checkup and blood analysis, i was told by my md to start taking vit. Furthermore, magnesium is needed to activate vitamin d. Because the vitamin is necessary for bone health, many doctors recommend supplements for older people to help prevent breaks and falls. While symptoms are more or less non-existent, the result of a vitamin d deficiency can be more serious. Calcium can be found in food sources (Table 1) or dietary supplements (Table 2).
Natural Factors D3 Cholecalciferol
Adequate vitamin d during pregnancy also appears to reduce the chances of having a low-birthweight baby. Dark-skinned people living in temperate climates have been shown to have low vitamin d levels but the significance of this is not certain. Geographical location: People who live in northern latitudes or areas of high pollution, work night shifts, or are homebound should aim to consume vitamin d from food sources whenever possible. However, the national institutes of health (Nih) say that vitamin d toxicity is unlikely at intakes under 10,000 iu per day. Animal studies and a limited number of observations from human cases offer insight into alterations in vitamin d metabolism during states of intoxication (37, 38, 41, 42). Although the body can create vitamin d, a deficiency can occur for many reasons. A number of trials also had oral calcium supplements as part of the intervention, and we abstracted this information. Parathyroid function and vitamin d metabolism during human growth hormone replacement.
This larger dose may be seen as more convenient for patients or healthcare providers who want to provide supplementation on a weekly or monthly basis. The role of vitamin d in reducing cancer risk and progression. Came across the nutravita vitamin d3 4,000 iu, it peaked my interest. Interesting information about vitamin d status in patients with ghd before and after substitution treatment with rgh can be extrapolated from the italian prospective study by ciresi and colleagues. Winter vitamin d3 supplementation does not increase muscle strength, but modulates the igf-axis in young children. The most important steps in vitamin d metabolism are shown in figure 1, vitamin d hydroxylation to 25-hydroxyvitamin d (25Ohd) in the liver depends on substrate availability, and therefore, 25ohd concentrations rise in circulation during excess or intoxication. Furthermore, vitamin d intoxication has been reported after misunderstanding of physician instructions, emphasizing the need for improved communication regarding dosing. Revitahip active vitamin d protocol (Initial 250,000 iu followed by 800 iu vitamin d3 and 500 mg calcium daily at 4 weeks shows significance in reducing falls.
There is evidence of efficacy for it’s therapeutic use in several medical conditions, as well as of the dangers associated with vitamin d insufficiency or deficiency. I take vitamin d3, vitamin k2, vitamin b12, coq10, turmeric cucumin with black pepper, biotin, multivitamin, ashwagandha, glucosamine sulphate, maca root. Table 3 reports the main studies that investigate the correlation between vitamin d metabolites and growth in children. Most people are not deficient in vitamin d, but they do not have an optimal level of vitamin d either. Please note that cholecalciferol is available in 50,000 iu as well and is stocked in most pharmacies. Yet the endocrine society recommends a greater amount of supplementation for children at risk for vitamin d deficiency or low bone density mass: From 400 to 1,000 iu for children 1 year and younger, and 600-1,000 iu for all older children, adolescents, and adults. Foodpharmacy Blog has helped millions of people find the best of the best when it comes to all sorts of products and services, including vitamin d supplements. Lowered pth concentrations in response to vitamin d supplementation have been associated with lower fracture risk (54, 55). We also chose products containing vitamin d with no other dietary supplements.
1 A recent attempt to quantify the vitamin d production from sun exposure at different times of the day, at different latitudes, and in people with different amounts of skin pigmentation, found too much variation in vitamin d produced to accurately predict whether an individual would meet official recommendations of daily vitamin d needs, leading the authors to favor vitamin d supplementation. Summary estimates according to supplementation doses were estimated. I liked the look of the bottle and the idea of vitamin k being combined with vitamin d3, my usual vitamin d3 was always an oil-based substance contained in gelatin sometimes veggie form so i must admit i was surprised by this powder substitute. The recent increase in vitamin d interest by the general public has fuelled a big rise in sales of over-the-counter vitamin d preparations. Gastrointestinal effects and renal calculi continue to be mentioned as statistically more likely in vitamin d treatment groups than placebo groups. Often these patients are overweight, which could be affecting their vitamin d levels. In addition, people who have darker skin need more sun exposure to produce adequate amounts of vitamin d, especially during the winter months.
Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders.