Product name: Nature’s Way, Pycnogenol, Pine Bark Extract, 50 mg, 30 Tablets
Quantity: 30 Count, 0.02 kg, 4.3 x 4.3 x 8.6 cm
Categories: Nature’s Way, Supplements, Antioxidants, Pine Bark Extract, Pycnogenol, Vegetarian
Premium Quality, Pine Bark Extract, With 100% DV Vitamin E, Certified Potency, Vegetarian, Pycnogenol Horphag Research, Dietary Supplement, Health through the power of nature—that’s what it means to Trust the Leaf, Pycnogenol is an extract made from the bark of the Maritime Pine (pinus pinaster). Pycnogenol contains naturally occurring proathocyanidins, organic acids and other biologically active components. Vitamin E is a powerful antioxidant and a potent free-radical scavenger. Our Pycnogenol is carefully tested and produced to superior quality standards.
The extract properties were analyzed using wst-1, lowry, and cell migration assays as well as immunofluorescence staining. In vitro and animal studies using the standardized extract have indicated a multimodal action of pycnogenol, and several human studies have shown improvements in cognitive function after chronic administration. Early empirical usage of pine bark is explained through the observation that the natural pine-bark antioxidants that protect against free oxygen radicals also possess anti-inflammatory activity. We previously reported that pycnogenol prevents vascular endothelial cells from injury induced by an organic oxidant t-butyl hydroperoxide. It is the largest study to date of pine bark extract and cvd risk factors. The adverse events and adverse effects questionnaire asked about symptoms commonly reported in past studies of pine bark extract, hospital and emergency department visits, new diagnoses, and changes in existing diagnoses. Consistent with our recruitment of a population with blood pressures above the normal (120/80 Mm hg) range, the mean (Sd) blood pressures at baseline were 132,6 (10,9)/78,6 (7,9) Mm hg for the pine bark extract group and 133,2 (10,9)/79,9 (7,7) Mm hg for the placebo group. Results of recent studies also suggest that pine bark extract may have additional cardiovascular benefits, including enhanced glycemic metabolism, 8, 9 reduced body weight, 12 and improved lipid profile.
Nature’s Way, Pycnogenol, Pine Bark Extract, 50 mg, 30 Tablets: Pycnogenol, Pine Bark Extract, Antioxidants, Supplements
Although a different dosage or formulation might produce different results, our findings argue against recommending this pine bark extract to improve cvd risk factors. In addition to the antioxidant activity, pycnogenol enhances production of vasodilatory endothelial nitric oxide and prostacyclin. Pycnogenol also augmented the proliferative capacity of haemopoietic progenitors of bone marrow in samp8, these data suggest that pycnogenol may be useful for either retardation or restoration of parameters associated with ageing. Despite our extensive subgroup analysis, the only suggestion of an effect was for participants with baseline systolic blood pressure of 130 mm hg or higher, among whom the mean (Sd) lipoprotein(A) level decreased by 2 Nmol/l among 37 individuals in the pine bark extract group (Baseline level, 37 nmol/l) and increased by 4 Nmol/l among 38 individuals in the placebo group (47 Nmol/l). Pycnogenol, rich of many phytochemicals of medical value, is a commercialized nutrient supplement extracted from the bark of european coastal pine. A study of 146 people suffering from a common cold found supplementing with pycnogenol was able to reduce the duration (I. The researchers concluded that pycnogenol may increase production of hyaluronic acid and collagen, which are both found in many popular antiaging products.
All five studies reported subjective improvements in cvi-related symptoms in the pycnogenol treatment groups. Two of the studies supplemented subjects with 150 mg/day, while the latter used 100 mg/day. No beneficial effects of pine bark extract on cardiovascular disease risk factors. However, these cutaneous antioxidants can be depleted by sun exposure and environmental insults, resulting in an overload of oxidation products. In this study, we compared the response of human breast cancer cells (Mcf-7) and normal human mammary cells (Mcf-10) to apoptosis in the presence of pycnogenol. In a trial of 60 children with asthma, 16 out of the 30 in the treatment group were able to stop using their inhaler after taking 1 mg of pycnogenol for 3 months. These data begin to provide the basis for the conceptual understanding of the biological activity of pycnogenol and possibly other polyphenolic compounds as therapeutic agents in various human disorders. In an open, controlled comparative study 40 patients with diagnosed cvi were treated either with 600 mg chestnut seed extract per day or 360 mg pycnogenol per day over a period of 4 weeks. Gel-shift analysis of huvec demonstrated that pretreatment with pycnogenol exhibited a concentration-dependent suppression of tnf-alpha-induced activation of nf-kappa b. In vitro inhibition of helicobacter pylori growth and adherence to gastric mucosal cells by pycnogenol. Thus, topical antioxidants that replenish the antioxidant capacity of the skin have the potential to prevent oxidative damage.
Is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest france and is found to contain a unique combination of procyanidins, bioflavonoids and phenolic acids, which offer extensive natural health benefits. Thus, smoking-induced enhanced platelet aggregation was inhibited by 500 mg aspirin as well as by a lower range of 100-125 mg pycnogenol. The pine tree is native to the western and southwestern mediterranean regions but has rapidly naturalized to other countries, including the united states, england, south africa, and australia. Pinus eldarica (Pinaceae) is commonly known as tehran pine and planted in many parts of iran, afghanistan, and pakistan. Nevertheless, we still would have expected improvement in cvd risk factors given the putative biologic mechanism of antioxidants. This metabolite is no constituent of the extract, but is generated in vivo from the procyanidins Catechin units through multiple step reactions. Pine bark extract is generally well tolerated, with occasional minor gastric discomfort, dizziness, nausea, and headache. Foodpharmacy Blog and it’s editors do not ensure that unforeseen side effects will not occur even at the proper dosages, and thereby does not assume liability for any side effects from supplements or practices hosted under the domain of examine. Depending on the extraction process and the source pinus species used (P. The antioxidant activity of phytochemicals may be partially responsible for the reduced cancer risk.
To investigate possible mechanisms involved in pycnogenol’s suppression of peroxide release, confluent monolayers of j774 cells were incubated with pycnogenol for 18 h, washed, resuspended in phosphate buffered saline, and sonicated to obtain a cell lysate. Growth in the pays de mont treatment was completely absent and dieback symptoms appeared at the end of the first growing season, showing that the tamjoute pines were more resistant (Table ii). Pine bark extract has been studied for multiple conditions including diabetic retinopathy and ulceration, tinnitus, hemorrhoids, hyperpigmentation in melasma, menopausal symptoms, motion sickness, traveler’s thrombosis, control of inflammation in lupus patients, as an adjunct for childhood asthma, and in a chewing gum for gingival bleeding and plaque. The mixed results suggest that pycnogenol blood-pressure lowering effects may be dependent on the underlying cause of hypertension. There is additional evidence to support that pycnogenol may be helpful in other ways for people with diabetes. Studies have shown that pycnogenol can increase blood flow, and support better circulation by preventing blood clotting and the restriction of arteries caused by stress. Clinical studies using pine bark extracts report no clinically important adverse events at doses of 150 mg daily; however, few studies evaluate safety as a primary outcome.
Nature’s Way Pycnogenol
Pycnogenol (Pyc-nah-gen-ol) is a patented french maritime pine bark extract from horphag research. Study participants took pycnogenol as a supplement, and it was found to be most effective in women who started out with dry skin. Eleven sle patients were treated with first line medication according to disease activity and in addition, six of them received pycnogenol and five a placebo. One study found pycnogenol is not effective in treating adhd in adults. This formulation of pine bark extract is extracted from the milled bark of pinus pinaster (Also known as pinus maritime and pinus maritimus) using heated water. Mugo could be considered as a potential plant source for isolation of essential oil as well as flavonoids and other phenolics as they exhibit promising antioxidant activity. We assessed whether an effect of pine bark extract might be limited to particular participant subgroups because participant baseline variables were within the normal range for many outcomes. The evolution from willow bark to antiplatelet aspirin is synonymous with the successful development of modern science. In this study, we used macrophages (A major cell type in inflammation) to study the antiinflammatory effect of pycnogenol. Although these supplementations are individually known to benefit rheumatoid arthritis (Ra), there is no evidence suggesting any synergic effect.
The bark, from trees grown along the coast of southwest france, is processed and turned into a tonic that contains powerful antioxidants and anti-inflammatory compounds. Of the extract, and advocates say the antioxidants fight oxidative stress involved in disease development. The free radical generated from the oxidation of a french maritima pine bark extract pycnogenol (Pyc), by the horseradish peroxidase (Hrp)-hydrogen peroxide (H2o2) system at ph 7,4-10,0 was studied using electron spin resonance (Esr) spectrometer. It’s worth taking a chance and i am pretty critical with supplements because i have had bad experiences ordering them online in the past. If you have too many free radicals in your system and not enough antioxidants to counterbalance them, your cells can become damaged through oxidization. More research is needed to determine which individuals with hypertension may benefit from supplementation. None of the researchers has financial or consulting ties to the supplement company.
Pinus morrisonicola hayata, usually called taiwan five-leaf pine (5Lp), is an endemic species in taiwan and is traditionally used to relieve hypertension symptoms and improve cardiovascular function. Because of it’s favorable safety profile and sustained anti-inflammatory action, pycnogenol represents an option as an add-on supplement for oa patients. Unlike other supplement fads, this is one herbal ingredient that may be worth following. Two other studies 12, 14 showed no effect of pine bark extract on hdl-c level. Clinical trial results suggest pine bark extract improves skin hydration and elasticity in women. Some anti-aging skin creams and cosmetics contain pycnogenol. Pine bark extract is composed of 80% to 85% proanthocyanidins, the monomers catechin and taxifolin (5%), And phenolic acids, including derivatives of benzoic and cinnamic acids (2% To 4%). In this study, we investigated the anti-tumor effects of pycnogenol on hl-60, u937 and k562 human leukemia cell lines. Thanks to extensive research into the safety and efficacy of pycnogenol, we now know that there are many health benefits that our ancestors could only suspect through trial and error applications. Studies have also shown that pycnogenol can have a positive effect on arthritis and osteoarthritis. Inhibition mechanisms of bioflavonoids extracted from the bark of pinus maritima on the expression of proinflammatory cytokines. Moreover, pycnogenol reduces serum levels of low-density lipoproteins (Ldl) cholesterol and increases high-density lipoproteins (Hdl) cholesterol.
There are limited clinical data showing pine bark extract can be used together with standard blood pressure medication. These observations suggest an advantageous risk-benefit ratio for pycnogenol. Pine bark extract is recommended to improve the health and smoothness of the skin, including damage caused by overexposure to sunlight. Pycnogenol is a trade name for a supplement derived from french maritime pine bark extract. The aim of this study is to investigate anticancer effect of pycnogenol in mc-3 human mucoepidermoid carcinoma (Mec) cell line. I’ve been taking pine bark (Pycnogenol) since the 90S to help me manage my adhd and nothing is more powerful and helping me concentrate and alleviate many of the negative symptoms of adhd. Reduction of cardiovascular risk factors in subjects with type 2 diabetes by pycnogenol supplementation.
Evaluation of antioxidant activity was made using dpph and tbars test.