Product name: Now Foods, Alpha Lipoic Acid, Extra Strength, 600 mg, 120 Veg Capsules
Quantity: 120 Count, 0.16 kg, 6.4 x 6.4 x 11.4 cm
Categories: Now Foods, Supplements, Antioxidants, Alpha Lipoic Acid, Kosher, Vegetarian, Vegan, Gmp Quality Assured, Produced In A Gmp Certified Facility
Extra Strength, Free Radical Scavenger, With Grape Seed Extract and Bioperine, Kosher, A Dietary Supplement, Vegetarian/Vegan, General Health, Family Owned Since 1968, GMP Quality Assured, Alpha Lipoic Acid (ALA) is naturally produced in the human body in very small amounts, but it is also available in some foods. ALA is unique in that it can function in both water and fat environments. ALA promotes the production of glutathione and can also recycle vitamins C and E, thereby enhancing their antioxidant activities. In addition, ALA may help to maintain healthy neural tissues, promote proper glucose metabolism and support healthy cardiovascular function.
Because of the extreme difficulty (And high cost) of isolating natural (R)-ala, researchers in the us and europe originally conducted studies with synthetic lipoic acid. Memory loss in old rats is associated with brain mitochondrial decay and rna/dna oxidation: Partial reversal by feeding acetyl-l-carnitine and/or r-alpha -lipoic acid. Research has shown that alpha-lipoic acid may affect weight loss in several ways. Neuroprotection by the metabolic antioxidant alpha-linoic acis. We were unable to evaluate the dose response association between supplementation dose and inflammatory markers due to the low number of studies included. (Note: Urine odor is common when taking lipoic acid). With respect to the antioxidant capacity of ala, it has been pointed out that it is a powerful redox pair that is capable of neutralizing different ros. Very good potency i provide alpha lipoid acid to a certain subgroup of my patients and they all agree that the 600mg vitamin world product works better than the 600mg capsules from other on-line supplement stores. Reported that administration of lipoic acid reduced relapse frequency and decreased corticosteroid consumption in patients with ms. As an antioxidant, it works throughout the body to neutralize harmful free radicals in a variety of ways. Consequently, blood glucose concentrations should be monitored closely when lipoic acid supplementation is added to diabetes treatment regimens.
Now Foods, Alpha Lipoic Acid, Extra Strength, 600 mg, 120 Veg Capsules: Alpha Lipoic Acid, Antioxidants, Supplements
Antioxidant properties of lipoic acid and it’s therapeutic effects in prevention of diabetes complications and cataracts. Regarding the efficacy of oral lipoic acid supplementation, an initial short-term study in 24 patients with type 2 diabetes mellitus found that the symptoms of peripheral neuropathy improved in those who took 600 mg of lipoic acid three times a day for three weeks compared to those who took a placebo. Metabolic maintenance vitamins and supplements are time-tested and physician-approved. Ala is also able to regenerate the reduced forms of other antioxidants, such as vitamins c and e. Alpha lipoic acid can lower the level of vitamin b1 (Thiamine) in the body. Studies have also discovered that alpha-lipoic acid may ease symptoms of diabetic neuropathy, which is nerve pain caused by uncontrolled diabetes (14, 15). Foodpharmacy Blog and it’s editors do not ensure that unforeseen side effects will not occur even at the proper dosages, and thereby does not assume liability for any side effects from supplements or practices hosted under the domain of examine. In addition to it’s function as a radical scavenger, lipoic acid has chelating capability.
Com and it’s editors do not advocate nutritional supplementation over proper medical advice or treatment and this sentiment will never be expressed through pages hosted under examine. Humans only produce alpha-lipoic acid in small amounts. Pharmacokinetic studies in humans have found that about 30%-40% of an oral dose of a racemic mixture of r-lipoic acid and s-lipoic acid is absorbed (6, 7). During this time i was also on a prescription drug and yet the alpha lipoic acid made a significant difference that the rx alone could not do. Alpha-lipoic acid in the treatment of diabetic polyneuropathy in germany: Current evidence from clinical trials. Effects of alpha lipoic acid supplementation on serum levels of il-8 and tnf-alpha in patient with esrd undergoing hemodialysis. Ala is an antioxidant that protects against damage to the body’s cells from free radicals.
Some studies have shown that lipoic acid can help support weight loss by suppressing hypothalamic ampk activity. All subjects were independent and had a medical diagnosis of type 2 diabetes mellitus for one to three years without complications or comorbidity and were under medical treatment in a public hospital: (I); (Ii) medicines: All patients taking two tablets of glibenclamide/metformin (5/500 Mg) per day as a hypoglycemic treatment and not taking antioxidant supplements (Vitamins or minerals) nor anti-inflammatory drugs for at least 6 months prior to initiation of or during the study; (Iii) habits: No smoking, no frequent alcoholic drinks (Less than two drinks or beers per week), or no drug addictions (Marijuana, cocaine and others) in the last three years; and (Iv) sedentary: All participants who reported that they do not exercise regularly during the last year. This is why it’s actually known as the and quot;universal antioxidant! Effect of alpha-lipoic acid and vitamin e supplementation on oxidative stress, inflammation, and malnutrition in hemodialysis patients. While considered safe, there are no guidelines directing the appropriate use of alpha-lipoic acid. They discovered that in addition to being a powerful antioxidant in it’s own right, ala is able to raise intracellular glutathione levels. Most oral supplements are sold in formulations ranging from 100 to 600 mg. In combination with other anti-oxidants, supplements and diet changes, this has effectively given me my life back. Alpha lipoic acid is an antioxidant that the body actually produces.
In another parallel-designed trial, the effect of 300 mg ala supplementation was tested in type 2 diabetic patients by mazloom et al. Alpha lipoic acid (Ala) is a natural compound that functions as a co-factor in vital, energy-producing reactions. In the same analysis, alpha-lipoic acid did not significantly affect waist circumference. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. I personally take this crucial supplement as a preventative measure as one of the most powerful antioxidants out there. Alpha-lipoic acid can also recycle used antioxidants, including vitamin c, vitamin e, and a potent amino acid compound known as glutathione. Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase. Alpha-lipoic acid as a biological antioxidant. However, all of the published human studies have used r,s-lipoic acid (Racemic mixture). The most frequently reported side effects of oral lipoic acid supplementation are allergic reactions affecting the skin, including rashes, hives, and itching.
Now Foods Alpha Lipoic Acid
As science has shown, the human body relies on both internal and external antioxidants for a lifetime of protection, and ala is uniquely capable of playing both protective roles. In addition to the physiological functions of protein-bound lipoic acid, there is increasing scientific and medical interest in potential therapeutic uses of pharmacological doses of free (Unbound) lipoic acid. Lipoic acid occurs naturally in food covalently bound to protein, whereas supplements contain unbound (Free) lipoic acid. Ala is also widely available as an over-the-counter supplement. A trail of research from lipoic acid to alpha-keto acid dehydrogenase complexes. Induction of endogenous antioxidants and phase 2 enzymes by alpha-lipoic acid in rat cardiac h9c2 cells: Protection against oxidative injury. I never cease to be impressed by the effectiveness of supplements by bulksupplements. What most impressed researchers was the discovery that ala functions as both a fat and water-soluble antioxidant that can easily cross cell membranes. The result showed that daily oral administration of 300 mg of lipoic acid for three months prevented the deterioration of contrast sensitivity in patients with diabetes and improved it in healthy patients compared to placebo.
And quot; spring valley alpha lipoic acid capsules are specially formulated to help support antioxidant health in the body, and they also contribute to nerve health and sugar metabolism. When an antioxidant molecule reacts with an unstable free radical molecule, the antioxidant molecule itself becomes oxidized and loses it’s benefits until it is reduced again. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. Because alpha-lipoic acid is a powerful antioxidant, studies have examined it’s ability to slow the progression of disorders characterized by memory loss, such as alzheimer’s disease. Eg received 600 mg of racemic alpha-lipoic acid (Two capsules of 300 mg per day), pg received two capsules containing microcrystalline cellulose (295 Mg) plus magnesium stearate (5 Mg) of pharmaceutical presentation similar to that of the treatment, and cg did not receive any treatment. Combination of alpha lipoic acid (Thioctic acid), silymarin, and selenium: Three case histories. In cells, lipoic acid is swiftly reduced to dihydrolipoic acid, and in vitro studies indicate that dihydrolipoic acid is then rapidly exported from cells. There may also be differences in bioavailability of the two isomers of lipoic acid.
Alpha lipoic acid has so many uses, it is like magic in a bottle. These findings can be explained by rising effect of the supplement on reduced gsh levels in tissues gsh peroxidase activity and nitric oxide production in endothelial cells. Available information regarding the effects of ala supplementation on inflammatory cytokines is inconclusive. Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. I do not know whether it was simply this product or it complementing other supplements i am taking, but the pain and condition is improving. Alpha-lipoic acid (Ala) is an amphipathic substance, which is synthesized in the mitochondria of plants and animals from octanoic acid and cysteine as a sulfur donor through the reactions catalyzed by the enzyme lipoic acid synthase. Although the body does produce alpha lipoic acid on it’s own, it may be a good idea for patients to include this nutrient in their daily vitamin regimen, especially if they have blood glucose control issues or other health concerns improved by ala. Both lipoic acid and dihydrolipoic acid have been found to inhibit copper- and iron-mediated oxidative damage in the test tube (22, 23) And to inhibit excess iron and copper accumulation in animal models (24, 25). Much has been written about the efficacy of ala as an antioxidant that is both fat and water soluble, and dr. The use of lipoic acid is currently approved for the treatment of diabetic neuropathy in germany. Lipoic and dihydrolipoic acids as antioxidants.
There is some controversy over antioxidants in general, with some studies showing a negative effect from some individual antioxidants, so i recommend evaluating each product individually. There is confusion between alpha-lipoic acid and alpa linolenic acid because both are sometimes abbreviated ala. Another analysis of 12 studies found that people who took alpha-lipoic acid lost an average of 2,8 pounds (1,27 Kg) more than those taking a placebo over an average of 23 weeks. The non-accidental ingestion of a very high dose of lipoic acid led to multi-organ failure and subsequent death of an adolescent girl. Free (Unbound) lipoic acid supplements may contain either r-lipoic acid or a 50:50 (Racemic) mixture of r-lipoic acid and s-lipoic acid (See supplements). Suggested use: As a dietary supplement, adults take one Or more tablets per day as directed by your healthcare provider. In addition to glutathione, lipoic acid is an important thiol antioxidant, and exerts it’s protective effects by scavenging free radicals, chelating metal ions, and recycling antioxidants.
Now Foods, Alpha Lipoic Acid, Extra Strength, 600 mg, 120 Veg Capsules Product Review
Alpha lipoic acid. Extra Strength, 600 mg. ALC. good afternoon. No way. For Metabolism. Love it. Caution GIT. Good. Included in the four health. ALA
A new, well-proven drug (as a rule, this is some kind of vitamin or other dietary supplement, which suddenly revealed useful side effects), as thousands of volunteers immediately try it out, not in the framework of controlled scientific research, but in framework of spontaneous interest. So, lipoic acid (it is thioctic, it is alpha-lipoic, it is also thioctacid) is the current object of universal worship. The substance was discovered in the middle of the last century. Initially, lipoic acid was considered a vitamin, and then we found out that it is synthesized in the human body, but its concentration in blood serum decreases with age. In the late 80s – early 90s, scientists established a clear link between the deficiency of endogenous lipoic acid and liver diseases, and also found its antioxidant and hypoglycemic properties. It turned out that the drug is able to fight the formation of free radicals (which are responsible for aging processes), restore liver cells, increase the concentration of vitamins E and C, and also have a beneficial effect on the metabolism of carbohydrates and fats in the body. In particular, lipoic acid contributes to the rapid uptake of glucose by cells and prevents the fatty degeneration of the liver. Such useful qualities of thioctacid did not go unnoticed by doctors of various specialties – first of all, gastroenterologists, endocrinologists and neurologists. Lipoic acid began to be used to treat liver damage – including alcohol, as well as to combat the complications of diabetes. In the injection form, it is prescribed, in particular, for the treatment of diabetic neuropathy – damage to the nerves of the legs due to chronically elevated blood sugar. Facts about the improvement of fat metabolism and antioxidant properties have aroused additional interest among bodybuilders and women interested in ways to preserve youthful skin. But it is important to understand two facts – firstly, lipoic acid reduces the accumulation of fat deposits, but does not eliminate the folds already present on the sides. So you can consider this drug only as an addition to diet and exercise in a reputable fight with excess weight, nothing more. Well, and as a protection of the liver against any harmful effects (it is worth remembering that drinking alcohol in any quantity during therapy with lipoic acid is strictly prohibited!). Lipoic acid is a part of many expensive creams and other cosmetics. On the other hand, the possible side effects of the use of this drug in doses exceeding those recommended have not been studied. No one knows whether it is possible to prescribe lipoic acid to pregnant women, whether there can be negative consequences of dragging this drug in the long term. In general, I will recommend to consult a doctor before experimenting with a fashionable medicine. But the choice is yours.
I read about it and decided to try it. But one must be careful with it, because it has the property to bind metals and remove them. Therefore, it can not be taken with magnesium, iron, calcium, and drink after 2 hours. Later I will supplement the review.
Great drug, suitable for those who want to reduce their sugar intake
I did not notice any changes.
This is the second time I’ve bought this product. To improve metabolism and type 2 diabetes. But if I drink 30 minutes before a meal, then heartburn starts. I drink 10 minutes before a meal. All health!
For this purchase, the quality of this product feels very good and the taste is easy to accept. The product is similar to the seller’s description. I feel satisfied and really like it. The speed of delivery is average, and the packaging is very careful and rigorous. I am very satisfied with the shopping.
The dietary supplement is wonderful, but for people with gastrointestinal tract problems, in particular, weak mucous membranes, erosions, ulcers and gastritis, it should be taken with caution, thioctic acid itself burns very much, burning can be compared to black pepper, and it is enhanced by black pepper extract if to drink a capsule it will dissolve in one place somewhere in the stomach and it will be unpleasant to burn one section, it is best to open the capsule and drink the contents with a large volume of water? it is strange that the manufacturer himself is silent about this! All health and happiness)
I ordered myself and my parents a 3-month course. After the first month: A father with stage 2 diabetes (on the recommendation of a doctor) does not feel anything special. But he began to eat substantially less sweet. He says he does not pull. Overweight mom (for company with dad) says that the hips have become less cellulite. relief decreased. To the touch, the skin on the body has become smoother, velvety. I (because it’s fashionable) feel that my legs swell less. The thighs on the hips become somehow softer. I will watch further. We drink with the omega of the same manufacturer
I take more than six months. There are no side effects. I am not too careful to notice dramatic changes.
I finish the can, according to the scheme prescribed by the doctor. She said after 45 it is necessary to drink constantly. I drink in conjunction with other dietary supplements. Feeling good
Questions and Answers
Since ALA is very dangerous to take (when not according to half-life in small doses, e. i. according to the work of dr. Andrew Cutler) if you have any level av mercury toxicity (which everybody has to some degree), wouldn’t this product be far more damaging than helpful?
Is this ala natural or synthetic, (R or S), also is it stabilized?
Since this product contains ALA which is very dangerous to take (when not according to half-life in small doses, e. i. according to the work of dr. Andrew Cutler) if you have any level av mercury toxicity (which everybody has to some degree), wouldn’t this product be far more damaging than helpful?
Our family uses kinesiology (& other methods) to test if a product is beneficial and at what doses. One type of kinesiology is taught by Dr Dietrich Klinghardt. Quicksilver Labs has a good labs & protocols, btw, for addressing mercury toxicity. Dr Ben Lynch also has much free info avail online for addressing detox. Hth.
There is no information on the bottle regarding the source (natural vs. synthetic), the optical isomer (R/S) or whether it is stabilized. The product does contain grape seed extract if that is of any help.