Product name: Now Foods, Pycnogenol, 30 mg, 150 Veg Capsules
Quantity: 150 Count, 0.11 kg, 6.4 x 6.4 x 11.4 cm
Categories: Now Foods, Supplements, Antioxidants, Pine Bark Extract, Pycnogenol, Vegetarian, Vegan, Non Gmo
Free Radical Scavenger, With 300 mg Bioflavonoids, Healthy Vascular Function, Balanced Immune Response, Pycnogenol Horphag Research, A Dietary Supplement, Vegetarian/Vegan, Non-GMO, General Health, Family Owned Since 1968, Quality GMP Assured, Pycnogenol is a unique combination of proanthocyanidins obtained from the bark of the French maritime pine. As a potent natural scavenger of free radicals, Pycnogenol helps to protect the body’s tissues from oxidative stress and supports a healthy, balanced immune system response to normal metabolic stress. Through these mechanisms, Pycnogenol helps to maintain vascular strength and function.
Pine bark extract is used to reduce the risk and severity of heart disease, strokes, high cholesterol, and circulation problems. Research has shown that taking pycnogenol daily for 2 months can prevent or reduce the symptoms of retinal disease caused by diseases such as diabetes and atherosclerosis. No side effects due to supplementation were observed; tolerability was optimal. Pine bark extract is gras, based on data from animal studies and clinical trials; however, few studies evaluate safety as a primary outcome. Confusion previously arose when grape seed extract was marketed as containing pycnogenol. The antioxidant properties of pycnogenol support the maintenance of healthy retinal capillaries and better vision. If you have too many free radicals in your system and not enough antioxidants to counterbalance them, your cells can become damaged through oxidization.
Now Foods, Pycnogenol, 30 mg, 150 Veg Capsules: Pycnogenol, Pine Bark Extract, Antioxidants, Supplements
Studies have shown that taking 30 – 150 mg pycnogenol daily helps support the mobility and flexibility of joints and reduces aches and pains. This information relates to an herbal, vitamin, mineral or other dietary supplement. 1 A majority of the studies reviewed in this article focus on it’s antioxidant, anti-inflammatory, and vasodilation properties. In this study, we examined the effects of proanthocyanidin-rich water extract (Pawe) isolated from p. Converging evidence suggests that the biomodulating effects of pyc improve several mechanisms that may underpin cognition including vascular, anti-inflammatory, neuroprotective, and antioxidant processes. While pycnogenol is a natural supplement, it can have powerful effects on your health, both positive and negative. In this study, we compared the response of human breast cancer cells (Mcf-7) and normal human mammary cells (Mcf-10) to apoptosis in the presence of pycnogenol. In conclusion, our results demonstrate the anti-inflammatory and antioxidant potential of hiper containing the natural products, pbe, honey, aloe vera, and papain. These increases were not influenced by oral consumption of pycnogenol or aspirin just before smoking. Regarding the food industry, pine bark extracts have been successfully used as antioxidants in the meat industry and have been proposed as interesting additives for the juice industry and songzhen noodles production. Pycnogenol (Procyanidin extracted from pinus maritima) has been shown to be a potent free radical scavenger and an antioxidant phytochemical.
Is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest france and is found to contain a unique combination of procyanidins, bioflavonoids and phenolic acids, which offer extensive natural health benefits. In some studies, the extracted compounds are designated procyanidiol oligomers. Radiata are medium-sized pines growing up to 30 m tall with bright red-brown, deeply fissured bark. Evaluation of antioxidant activity was made using dpph and tbars test. Foodpharmacy Blog and it’s editors do not advocate nutritional supplementation over proper medical advice or treatment and this sentiment will never be expressed through pages hosted under examine. These results suggest that the antiinflammatory effect of pycnogenol may at least in part be due to it’s ability to modulate the gsh redox cycle and activities of catalase and superoxide dismutase. Herein, we look at the most recent uses of pine bark extracts in the food industry and for biomedical purposes. M1 also displays structural features that allow oxidation under formation of an electrophilic benzoquinone that would be preferentially attacked at c4 by the nucleophilic thiol moiety of glutathione. Pycnogenol is one of the most powerful natural antioxidants.
We previously reported that pycnogenol prevents vascular endothelial cells from injury induced by an organic oxidant t-butyl hydroperoxide. All of the aforementioned studies showed improvement in the symptoms of knee osteoarthritis patients treated with pycnogenol. The strength of the association between arginine supplements and ed was assessed using relative odds ratios and weighted mean differences with 95% ci. The primary hypothesis was that pine bark extract would lower blood pressure in a population of overweight and obese participants with baseline prehypertension or hypertension. Nonetheless, it is important to note that a majority of research is based on the pycnogenol trademarked formula. Moreover, pycnogenol reduces serum levels of low-density lipoproteins (Ldl) cholesterol and increases high-density lipoproteins (Hdl) cholesterol. 2, 3, 5 The pharmacokinetics of maritime pine bark extract constituents have been studied in human volunteers. Some other species such as pilea cadieri, although rich in prodelphinidin, are not suitable as sources because of the inextractability of the tannin. Of 130 randomized participants, 7 participants (4 In the pine bark extract group and 3 in the placebo group) dropped out before the 6-week data collection point, and 2 participants in the placebo group dropped out after the 6-week data collection point, for a 93,1% retention rate (Figure 1). Study results showed that 18 of the 24 participants who took pycnogenol had an improvement in their vision, while no such improvements were observed in those who took the placebo.
Most subgroups reviewed suggest an overall beneficial effect on microvascular function, particularly grape-derived products, cocoa, tea, pine bark and rutaceae aurantiae. Antidiabetic effect of pycnogenol french maritime pine bark extract in patients with diabetes type ii. It is included in hundreds of dietary supplements, cosmetic products and functional foods and beverages worldwide. French maritime pine bark extract inhibits viral replication and prevents development of viral myocarditis. Of 4 participants in the pine bark extract group who dropped out, 2 were concerned about possible adverse effects of the supplement, 1 began a blood pressure medication, and 1 began cancer treatments. In this study, the needle extract of 5lp was fractionated and analyzed by lc/ms/ms to search for possible antihypertensive candidates. The extract is subsequently compounded with excipients of palatinit sugar, caramel, sucrose, fatty acid ester, and calcium stearate. Because pycnogenol lowers blood sugar, it may interact with other medications taken by people with diabetes. In this study, we tested the antioxidant and anti-inflammatory effects of a supplement, hiper health supplement (Hiper), on cytokine-induced inflammation and oxidative stress in human coronary artery endothelial cells (Hcaecs). Two of the studies supplemented subjects with 150 mg/day, while the latter used 100 mg/day. So far there is still limited information on which compounds of the complex extract are mainly responsible for the documented bioefficacy.
Now Foods Pycnogenol
To summarize, we found that caffeic acid, taxifolin, ferulic acid, and m1 all bind to human erythrocytes, but only the pycnogenol metabolite m1 revealed accumulation within the cells. Comparative effects of enzogenol and vitamin c supplementation versus vitamin c alone on endothelial function and biochemical markers of oxidative stress and inflammation in chronic smokers. Arthritis and inflammation have also been improved in studies using pine bark extract, as well as the uncomfortable symptoms of pms and menopause. Pycnogenol is a trade name for a supplement derived from french maritime pine bark extract. 2, 3, 4 However, clinical studies evaluating changes in antioxidant status after pine bark extract administration in humans have produced equivocal results. Researchers from loma linda university conducted a randomized, placebo-controlled, double-blind study evaluating the effect of pycnogenol as an adjunct therapy for asthma. Is available in more than 1,000 dietary supplements, multi-vitamins and health products worldwide. The proprietary extract comes from the bark of the french maritime pine tree pinas pinaster, which grows on the coast of southwest france. In vitro and animal studies using the standardized extract have indicated a multimodal action of pycnogenol, and several human studies have shown improvements in cognitive function after chronic administration.
No positive outcomes indicating that pycnogenol reduces intra-abdominal adhesions were obtained. Furthermore, past studies 8, 15 have shown decreases in cvd risk factors when pine bark extract was tested as an adjunct to conventional pharmacologic treatment. Our preliminary data indicated that 10% tahitian noni liquid dietary supplement or tahitian noni juice (Tnj), made from morinda citrifolia fruit by morinda inc, in drinking water for one week was able to prevent dmba-dna adduct formation. More recently, pycnogenol has been subjected to more than 100 research trials. Trusted suppliers of pycnogenol are those that have been gmp-certified. In this study, the antioxidant activity of several phytochemicals was compared using two different antioxidant assays: The oxygen radical absorbance capacity (Orac) assay, which measures the decrease in fluorescence decay caused by antioxidants, and the total oxyradical scavenging capacity (Tosc) assay, which measures the decrease in ethylene production caused by antioxidants. These constituents of pycnogenol could be detected in serum, blood cells, and synovial fluid of oa patients. 4 Consumption of pine needles is associated with abortion in cattle. It is the largest study to date of pine bark extract and cvd risk factors.
There are limited clinical data showing pine bark extract can be used together with standard blood pressure medication. In conclusion, pycnogenol was found to be more efficacious than venostasin for the treatment of cvi. An increasing body of evidence indicates that pycnogenol (Pyc), a standardized extract of french maritime pine bark, has favorable pharmacological properties. Furthermore, when we limited our analysis to subgroups with more extreme values of numerous risk factors, we also failed to detect an effect of this pine bark extract (At 200 mg/d) on outcomes. Pinus radiata bark extract exerts multiple biological effects and exhibits immunomodulatory and antioxidant properties. 2 Perhaps what makes pycnogenol unique is it’s potential to manage such a broad spectrum of conditions. Background: Pycnogenol is extracted from the pine bark of a tree known as pinus pinaster that has variety biological effects. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect. There is growing interest in the biologic activities of plant extracts such as that obtained from the bark of the french maritime pine pinus maritima, pycnogenol. Reduction of cardiovascular risk factors in subjects with type 2 diabetes by pycnogenol supplementation.
It is recommended that you take pycnogenol with or after meals to reduce potential side-effects to the gut. Pinus pinaster is a type of pine tree native to france. In total, 40 patients with diabetes, atherosclerosis and other vascular diseases involving the retina were enrolled; 30 of them were treated with pycnogenol and 10 with placebo. Sources especially rich in prodelphinidin were a number of ribes spp, salix cinerea and platanus acerifolia, from all of which the tannin was easily extracted.