Product name: Now Foods, Pycnogenol, 100 mg, 60 Veg Capsules
Quantity: 60 Count, 0.05 kg, 4.8 x 4.8 x 8.9 cm
Categories: Now Foods, Supplements, Antioxidants, Pine Bark Extract, Pycnogenol, Kosher, Vegetarian, Vegan, Non Gmo, Gmp Quality Assured, Produced In A Gmp Certified Facility
Free Radical Scavenger, Healthy Vascular Function, Balanced Immune Response, With Amla, Kosher, Pycnogenol Horphag Research, A Dietary Supplement, Vegetarian/Vegan, Non-GMO, General Health, Family Owned Since 1968, GMP Quality Assured, Pycnogenol is an extract of the bark of the French maritime pine that consists of a unique combination of proanthocyanidins. Pycnogenol is a potent free radical scavenger, support a healthy, balanced immune system response, and promotes the production of collagen, hyaluronic acid, and nitric oxide. Clinically and non-clinical studies have demonstrated that Pycnogenol can help to maintain healthy eyes, skin, and joints, and can support normal vascular structure and function.
Confusion previously arose when grape seed extract was marketed as containing pycnogenol. Evidence supports the use of dietary supplements such as fish oil for treating and preventing cvd, but rigorous evidence of efficacy and safety is lacking for most supplements. If you have trouble finding a supplier you trust, many of the active ingredients of pycnogenol can also be extracted from other sources, including peanut skin, grape seed, and witch hazel bark. One critical point with plant extracts is always the bioavailability of their constituents. In contrast, we evaluated the effects of pine bark extract as a solitary therapy, a design more likely to isolate the effect of pine bark extract. Moreover, pycnogenol reduces serum levels of low-density lipoproteins (Ldl) cholesterol and increases high-density lipoproteins (Hdl) cholesterol. Following our a priori primary analysis plan, the effect of pine bark extract on the primary outcome, 12-week blood pressure change, was examined using a regression model with 12-week blood pressure change as the dependent variable and with baseline blood pressure as a covariate. These observations suggest an advantageous risk-benefit ratio for pycnogenol.
Now Foods, Pycnogenol, 100 mg, 60 Veg Capsules: Pycnogenol, Pine Bark Extract, Antioxidants, Supplements
Pycnogenol, as a patented formulation of french maritime pine bark extract, is standardized to 65 percent to 75 percent procyanidin compounds by weight. Regarding the food industry, pine bark extracts have been successfully used as antioxidants in the meat industry and have been proposed as interesting additives for the juice industry and songzhen noodles production. However, it was found that the ultrasonic assistance increased the effect of extraction for recovery of phenolic compounds. Reactive oxygen species (Ros) production, lipid peroxidation, reduction of antioxidant enzymes, crystalline proteolysis, and apoptosis are considered factors that contribute to pathogenesis of age-related nuclear cataract. Insufficient evidence exists supporting the use of pine bark extracts for any long-term condition. The extract has been used for anemia, inflammation, and cardiovascular conditions. In total, 40 patients with diabetes, atherosclerosis and other vascular diseases involving the retina were enrolled; 30 of them were treated with pycnogenol and 10 with placebo. Nonetheless, it is important to note that a majority of research is based on the pycnogenol trademarked formula. Studies have shown that taking 30 – 150 mg pycnogenol daily helps support the mobility and flexibility of joints and reduces aches and pains. Should i take pycnogenol or regular pine bark extract?
In addition, no helps modulate key neurotransmitters such as dopamine, serotonin and norepinephrine. This summer registry study confirms the clinical and microcirculatory efficacy of pycnogenol in cvi and venous microangiopathy. Pine bark extract has not been shown to treat or prevent cancer. Doses of pine bark extract have been studied in clinical trials, most commonly at 150 mg per day in 3 divided doses. Pine bark has been used as a food source in emergencies. The mechanism of action of pycnogenol may be related to it’s free radical (Fr) scavenging, anti-inflammatory and capillary protective activities. Maritime pine extract is included in the united states pharmacopeia. The study’s authors suggest that pine bark extract may help stimulate circulation in the retina and inhibit swelling, which in turn may improve vision. To investigate possible mechanisms involved in pycnogenol’s suppression of peroxide release, confluent monolayers of j774 cells were incubated with pycnogenol for 18 h, washed, resuspended in phosphate buffered saline, and sonicated to obtain a cell lysate. It was unchanged after intake of 500 mg aspirin or 125 mg pycnogenol. Pinus radiata bark extract exerts multiple biological effects and exhibits immunomodulatory and antioxidant properties.
Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. It is included in hundreds of dietary supplements, cosmetic products and functional foods and beverages worldwide. The aim of our study was to investigate the effects of pycnogenol on the progression of diabetic retinopathy and other vascular retinal disorders. Pycnogenol, rich of many phytochemicals of medical value, is a commercialized nutrient supplement extracted from the bark of european coastal pine. In contrast, serum concentration of vasoconstrictory mediators endothelin-1 and thromboxane are lowered in response to supplementation with pycnogenol. Gel-shift analysis of huvec demonstrated that pretreatment with pycnogenol exhibited a concentration-dependent suppression of tnf-alpha-induced activation of nf-kappa b. Eleven sle patients were treated with first line medication according to disease activity and in addition, six of them received pycnogenol and five a placebo. The purpose of the present study was to examine whether 14 days of supplementation with maritime pine extract leading up to and following an exercise test would increase performance and reduce biomarkers associated with muscle damage, inflammation, and oxidative stress.
Anthocyanidin production and tannic acid equivalent (Tae) of extracts of species in which a and d type procyanidins have been reported to occur have been studied. Participants were asked to refrain from changing their diet, losing weight, and beginning new dietary supplements or medications during the study. Dietary supplements are increasingly used by people with osteoarthritis. Research has shown that taking pycnogenol daily for 2 months can prevent or reduce the symptoms of retinal disease caused by diseases such as diabetes and atherosclerosis. Thus, topical antioxidants that replenish the antioxidant capacity of the skin have the potential to prevent oxidative damage. Systolic blood pressure change for pine bark extract group and placebo group from baseline to 6 weeks and 12 weeks. These data begin to provide the basis for the conceptual understanding of the biological activity of pycnogenol and possibly other polyphenolic compounds as therapeutic agents in various human disorders. Today, we know that pine bark is a good source of vitamin c (The cure for scurvy) as well as numerous phytochemicals, natural plant compounds that support better health. Roy krebs is the founder and ceo of natural stacks, an open source supplement company with targeted brain health products to help improve mood, memory and focus. The extract has been widely studied for the past 40 years and has more than 420 published studies and review articles ensuring safety and efficacy as an ingredient.
Now Foods Pycnogenol
They have discovered pycnogenol is effective due to it’s double function. This review gives an overview of clinical studies demonstrating that supplementation with pycnogenol reduces platelet activity, lowers high blood pressure, relaxes artery constriction and improves blood circulation. In conclusion, this study showed that pnp supplementation reduced the serum cholesterol and triglycerides in broilers and it may improve the development of the digestive tract and antioxidant functions of broilers without altering growth performance. While pycnogenol is a natural supplement, it can have powerful effects on your health, both positive and negative. In one landmark study, women experienced a 34% reduction in abdominal menstrual discomfort during their first cycle with pycnogenol. Pine bark extract has been studied in a small clinical trial for pain in the third trimester of pregnancy at a dose of 30 mg/day; however, this should not be regarded as evidence of safety. Radiata bark extract effectively inhibits anaphylaxis-like reactions. Pycnogenol french maritime pine bark extract is scientific evidence based and a proprietary extract, which is protected by several u. In a trial of 60 children with asthma, 16 out of the 30 in the treatment group were able to stop using their inhaler after taking 1 mg of pycnogenol for 3 months. Study participants took pycnogenol as a supplement, and it was found to be most effective in women who started out with dry skin.
Pine bark extract has been clinically shown to help improve skin appearance and more. Ingredientsfrench maritime pine bark extract 300mg, cellulose (Vegetarian capsule), magnesium stearate, silica, rice powder. Pine bark extract is available through other companies not using pycnogenol, except that they may use different types of pine bark and have dissimilar formulations. The aim of this study is to investigate anticancer effect of pycnogenol in mc-3 human mucoepidermoid carcinoma (Mec) cell line. When catechin and palm oil vitamin e, catechin and coenzyme q Or coenzyme q And pycnogenol were combined, the individual effect was enhanced. Pine bark extract is gras, based on data from animal studies and clinical trials; however, few studies evaluate safety as a primary outcome. You are using anticoagulant and/or antiplatelet drugs: Pine bark extract can inhibit platelet aggregation and may increase risk of bleeding when used with these drugs. Histological sections of the intestines showed a dramatically better condition of the mucosal layers compared with the irradiated control animals administered water without pycnogenol. More research is needed to determine which individuals with hypertension may benefit from supplementation.
Citrus bioflavinoids and vitamin c are added for their synergistic antioxidant properties. The resulting inhibition of cartilage-destructing proteases and pain-producing cyclo-oxygenases provides the basis for relief from pain, improvement of stiffness, enhanced mobility, and well-being in three clinical studies with the pine bark extract as an adjunct supplement. Of the flavonoids tested, good protection in the retina was found at 10(-5) M for epigallocatechin gallate (50%) And at 50 ng/ml for pycnogenol (61%) And catechin (52%). A recent study showed that pycnogenol can offer protection from the free radicals that come from the harmful rays of the sun (Photoprotection) and may also reduce hyperpigmentation of the skin, improve the skin barrier function and extracellular matrix homeostasis (The maintenance of the structure of cells and soft tissues). The phosphate buffered saline (Pbs, ph 7,4) consisted of 137 mm nacl, 2,7 mm kcl, 8,1 mm na 2hpo 4 and 1,5 mm kh 2po 4, in case of incubation with erythrocytes the pbs buffer was supplemented with 0,1% (M/v) glucose. Pinus eldarica (Pinaceae) is commonly known as tehran pine and planted in many parts of iran, afghanistan, and pakistan. Pycnogenol also augmented the proliferative capacity of haemopoietic progenitors of bone marrow in samp8, these data suggest that pycnogenol may be useful for either retardation or restoration of parameters associated with ageing. Besides promoting healthy skin, pycnogenol is also clinically shown to support cardiovascular, circulatory, joint health and more.
Two of the studies supplemented subjects with 150 mg/day, while the latter used 100 mg/day. As a reminder, discuss the supplements and medications you take with your health care providers. Research shows that pine bark extract is capable of reducing pro-inflammatory cytokines il-1 and il-6, responsible for many of the adverse effects of chronic inflammation. Our objective was to determine the effects of pine bark extract on blood pressure and other cvd risk factors in overweight and obese adults with higher-than-optimal systolic blood pressure. Although not the most potent anti-inflammatory agent out there, pycnogenol has shown some efficacy in alleviating symptoms in patients with autoimmune disease. It’s worth taking a chance and i am pretty critical with supplements because i have had bad experiences ordering them online in the past.