Product name: Seagate, Lycopene-15, 15 mg, 90 Vcaps
Quantity: 90 Count, 0.07 kg, 5.8 x 5.8 x 9.9 cm
Categories: Seagate, Supplements, Antioxidants, Lycopene
Natural Lycopene Source, Health Food Supplement, 100% Pure, Freeze-Dried, No Fillers, No Solvents, Raw Material Source: Seagate grows a variety of Roma tomatoes which have maximum red color and lycopene level. Seagate has complete control over the entire operation, from planting and growing their crops to processing the tomato lycopene in their own factory. These tomatoes were not genetically-modified, nor subjected to any chemical or pesticide, Processing: Seagate freeze-dries the tomatoes using modern stainless-steel equipment. This method maintains the delicate balance of the phytonutrients, while concentrating the antioxidant compounds such as betacarotene, phytosterols, and lycopene, Lycopene: Each 500 mg capsule contains 3% lycopene, tested by independent laboratories using UV methodology. Seagate avoids using any solvents to concentrate the lycopene and thereby avoids having the residual ethyl acetate that is present in the capsules of many other brands of lycopene. This product provides dietary support for prostate and cervix health.
In a review of literature on lycopene and it’s potential role as a dietary antioxidant, the european food safety authority concluded that evidence was insufficient for lycopene having antioxidant effects in humans, particularly in skin, heart function, or vision protection from ultraviolet light. The ability of antioxidants to react with free radicals may prevent the destructive effects of these radicals and the resulting chronic diseases. This is the first systematic review that concentrates on the effect of lycopene supplementation on the progression of prostate cancer. A double-blinded rct to assess the ability of lycopene to slow down the progression of prostate cancer or to increase survival is required; however, the role of other carotenoids and phytochemical compounds in tomatoes also needs to be addressed. Further research has suggested that the high intake among smokers is nearly always due to supplements, and not food intake. Animal and epidemiological studies have suggested there may be an inverse relationship between selenium supplementation and cancer risk. The dietary/tomato lycopene intervention produced intermediate results. It will be the aim of future human intervention studies to include other lycopene containing fruits such as watermelon, papaya, red grapefruits, and guava, and consider synergistic effects with other components and their importance in primary and secondary cardiovascular prophylaxis. Bioavailability and in vivo antioxidant properties of lycopene from tomato products and their possible role in the prevention of cancer.
Seagate, Lycopene-15, 15 mg, 90 Vcaps: Lycopene, Antioxidants, Supplements
No toxic effects were observed in rats treated with lycopene 2,000 mg/kg/day for 28 days, an intake similar to approximately lycopene 200 mg/kg of body weight per day in humans. The trial was stopped early when researchers saw a significant increase in lung cancer among those taking the supplement compared to those taking the placebo. Subjects in each study arm (Cvd or hv) were sequentially allocated from a computer-generated randomisation to receive either lycopene 7 mg or placebo once daily for two months. The evidence favors lycopene supplementation as a therapeutic strategy in lowering bp among hypertensive individuals (60, 129). Vitamin e is a potent lipid-soluble antioxidant, which is well recognized for safeguarding the body against free radical-mediated peroxidative damage. It described 33 healthy people who were randomly allocated lactolycopene tablets, tomato paste or placebo (Whey proteins) alongside their usual diets. Secondary outcomes included forearm responses to sodium nitroprusside (Snp; measuring vascular smooth muscle sensitivity) and n g-monomethyl-l-arginine (L-nmma; measuring basal no synthase activity) infusion, arterial stiffness, blood pressure, serum lycopene concentrations, and safety and tolerability parameters.
Absolute change in serum lycopene calculated as final visit serum lycopene minus baseline serum lycopene. Max study: A randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Therefore, studies using these assay methodologies for aox status to illustrate the associated health effects of tomato intake or lycopene supplementation should be interpreted with caution. Developmental (Embryo-fetal toxicity/teratogenicity) toxicity studies of synthetic crystalline lycopene in rats and rabbits. The source of lutein in many lutein supplements is marigold flowers, while for zeaxanthin it is often red peppers. For example, when you exercise you produce extra free radicals that are essential to the health benefits that exercise brings, meaning that these extra free radicals trigger your cells to make your own antioxidants which give you the benefits of exercise. Results vary amongst individuals, but in most cases we would expect the beneficial effects of the supplement to build over several weeks.
These synergistic effects hamper assessment of quantitative and qualitative effects of lycopene as a dietary factor. These newspaper stories are based on the release of a new food supplement, the active ingredient of which is lycopene, a compound found in some red-skinned fruit including tomatoes. Also, the amount of vitamin c and other antioxidants in the skin is much higher, and it is recommended that in the consumption of tomatoes, the skin should not be discarded. The authors concluded that men older than 55 years should avoid supplementation with either vitamin e or selenium at doses exceeding dietary recommendations. Small studies suggest that lycopene supplements may be helpful in men with prostate cancer and for male infertility. Overall, few investigations have addressed the effects of lycopene or tomato intake on endothelial function. 10 To date, there is little scientific evidence to support a role of nutritional supplementation in the prevention or reduction of prostate cancer progression.
More information is needed on the potential effects of lycopene alone. The increase in serum lycopene in associated with the reduction in prostate-specific antigen(Psa)and a decrease in tumor size shown with daily lycopene supplementation. Randomized placebo-controlled trials, which can provide the strongest evidence, offer little support that taking vitamin c, vitamin e, beta-carotene, or other single antioxidants provides substantial protection against heart disease, cancer, or other chronic conditions. Elimination of 1 study with wide confidence intervals revealed a significant inverse association between dietary intake as well as blood concentrations of lycopene and prostate cancer risk. Both fish oil and omega-3 fatty acid supplements may lower the ability of your platelets to work, which can cause bleeding. More information is needed on the use of lycopene in people with brain tumors. 2 Lycopene prevented chemically induced dna and chromosome damage as well as tumor-promoting activity in liver cells through antioxidant activity and inhibition of growth factors and signaling pathways. Finally, improvements in lipid metabolism are modest but supportive for tomato intake versus taking a lycopene supplement. Therefore, it is evident that the effect of dietary antioxidants on risk of prostate cancer remains undecided and inconclusive.
In one study, fruhis (A ketosamine in dehydrated tomatoes) combined with lycopene resulted in greater growth inhibition of implanted rat prostate cancer cells than did lycopene or fruhis alone. In addition to enzymatic defenses, cells also rely on nonenzymatic molecules such as ascorbic acid, carotenoids, glutathione, or polyphenols to achieve cellular redox balance. Several studies have shown that antioxidants through diet help people’s immune systems, protect against free radicals, and lower the risk of developing cancer and heart disease. 22, Leitzmann mf, stampfer mj, wu k, colditz ga, willett wc, giovannucci el: Zinc supplement use and risk of prostate cancer. Vitamin e (Actually a group of 4 tocopherols and 4 tocotrienols) is the most popular supplement used by men. Many widely available dietary supplements are marketed to support prostate health. (Carotenemia also can be associated with over-consumption of carotenoid-rich nutritional supplements). In a controlled trial, 15 mg of lycopene significantly increased nk cell concentration, but no other immune functions. Early research reports that dietary lycopene intake from tomatoes may be linked to a lower risk of pancreatic cancer. 15 In an 8-week, double-blind, randomized, placebo-controlled trial, lycopene supplementation decreased dna oxidative damage. We have reviewed the results of lycopene supplementation and tomato-based food interventions on traditional and emerging cvd risk factors. Antioxidants, such as vitamin c, vitamin e, selenium and lycopene, can neutralize free radicals.
However, study results are mixed and most studies did not examine taking lycopene alone. But randomized controlled trials of patients with advanced cancer did not find significant benefit of supplementation over placebo. It is already evident from animal studies that a tomato product diet has a much greater effect than isolated lycopene. Like a few of it’s chemically-related compounds, like beta carotene (Found in eye vitamins, general antioxidant supplements, among other sources), lycopene is fat-soluble. There are numerous studies on the uses of lycopene in treating cancer and cardiovascular disease, as well as on it’s antioxidant and anti-inflammatory activity. A tomato-based, lycopene-containing intervention for androgen-independent prostate cancer: Results of a phase ii study from the north central cancer treatment group. Fractionate analysis of the phytochemical composition and antioxidant activities in advanced breeding lines of high-lycopene tomatoes. Among the approved products, the cost to obtain 10 mg of lycopene averaged 55 cents, with the lowest being 10 cents. However, the evidence available to date is insufficient to draw a firm conclusion with respect to lycopene supplementation in prostate cancer patients and larger rcts are required in broader patient groups.
There is inconclusive evidence for lycopene use in preventing cancers of the digestive tract. More studies on the effects of lycopene alone are needed. However, the protective effect of lycopene against various types of cancer is controversial because various studies have obtained conflicting results. Compared to placebo, 20 more people were dying every year when taking these two supplements. However, the available evidence remains limited and represents an opportunity for future research on the anti-inflammatory activity of tomatoes and lycopene. Lycopene is a powerful antioxidant with many health benefits, including sun protection, improved heart health and a lower risk of certain types of cancer. The specific mechanisms underlying benefits of a healthy diet are poorly defined and although dietary supplements receive much attention within the public arena, there is a paucity of well-conducted mechanistic studies. Others have introduced special eye vitamins that are predominantly lutein and zeaxanthin supplements. Researchers linked high lycopene intakes to a 9% lower likelihood of developing prostate cancer.
Also, it is unknown at this time whether supplements have the same effect as lutein and zeaxanthin obtained through food sources. Clinical trials began testing the impact of single substances in supplement form, especially beta-carotene and vitamin e, as weapons against chronic diseases. Indian researchers have shown that mice with diabetic neuropathy treated with lycopene showed attenuated latency and thermal hyperalgesia. That probably accounts for the price of lycopene as there is really only one source to get it and that has been used in studies. Life extension mega lycopene offers a middle of the road dosage of 15 mg of lycopene in a soy-free formulation that uses rice bran oil and sunflower lecithin as the primary solvents for lycopene. After standardizing treatment interventions on the basis of lycopene content of products, improvement in resistance to ldl oxidation was observed after consuming a variety of tomato products in amounts that delivered as low as an average of 8 mg of lycopene/d for 3 wk, Incorporating 100 g raw tomato and 15 g tomato paste twice per week, respectively, and 60 g tomato sauce thrice per week to 50,4 mg of lycopene/d for 1 wk, 126 G spaghetti sauce (39,2 Mg lycopene), or 540 ml tomato juice (50,4 Mg lycopene). Lycopene doses ranged from 6,5 mg/d lycopene (For 8 wk) to 75 mg/d (For 1 wk).
One study suggested that lower blood concentrations of lycopene were associated with early atherosclerosis in men. Most studies have examined the association of lycopene intake with the risk of all prostate cancers and have not separately considered indolent versus aggressive disease. Tomato-based products and lycopene supplements are generally well tolerated. Studies examining mixed supplementation with lycopene and other nutrient/supplements were excluded.