Product name: Solgar, Pycnogenol, 30 mg, 30 Vegetable Capsules
Quantity: 30 Count, 0.09 kg, 4.6 x 4.6 x 8.1 cm
Categories: Solgar, Supplements, Antioxidants, Pine Bark Extract, Pycnogenol, Non Gmo, Dairy Free, Casein Free, Vegan, Kosher Parve
Since 1947, Skin Health, Non-GMO, Gluten, Wheat and Dairy Free, Suitable for Vegans, Kosher Parve, Dietary Supplement, Pycnogenol is the extract from the bark of the French maritime pine tree, which grows in south-west France. It is a natural, concentrated source of plant-derived proanthocyanidins, a complex of naturally-occurring flavonoids and other biologically active components. Pycnogenol has antioxidant properties. In addition, this unique extract supports circulatory, joint and skin health.
Pycnogenol contains active ingredients that can also be found in peanut skin, grape seed, and witch hazel bark. Research has shown that taking pycnogenol daily for 2 months can prevent or reduce the symptoms of retinal disease caused by diseases such as diabetes and atherosclerosis. We chose a population at risk of developing cvd and not taking antihypertensive medications who would be likely to seek dietary supplements as an alternative therapy. Damage caused by free radicals can be minimized by taking antioxidant supplements of key nutrients such as pine bark extract. Approximately 60% of patients treated with pycnogenol(R) experienced a complete disappearance of edema (The most rapidly disappearing symptom) and pain at the end of the treatment, while almost all the patients reported a reduction in leg heaviness which disappeared in approximately 33% of patients. Our objective was to determine the effects of pine bark extract on blood pressure and other cvd risk factors in overweight and obese adults with higher-than-optimal systolic blood pressure. There is growing interest in the biologic activities of plant extracts such as that obtained from the bark of the french maritime pine pinus maritima, pycnogenol. Both in vitro and in vivo assays suggest a promising future for pine as an adjuvant therapy.
Solgar, Pycnogenol, 30 mg, 30 Vegetable Capsules: Pycnogenol, Pine Bark Extract, Antioxidants, Supplements
Pycnogenol, a standardized extract of french maritime pine bark, is composed of flavonoids, procyanidins, and phenolic acids. This review gives an overview of clinical studies demonstrating that supplementation with pycnogenol reduces platelet activity, lowers high blood pressure, relaxes artery constriction and improves blood circulation. Some other species such as pilea cadieri, although rich in prodelphinidin, are not suitable as sources because of the inextractability of the tannin. In vitro inhibition of helicobacter pylori growth and adherence to gastric mucosal cells by pycnogenol. Pine bark extract contains a group of compounds known as proanthocyanidins. Pine bark extract has been clinically shown to help improve skin appearance and more. Nevertheless, we still would have expected improvement in cvd risk factors given the putative biologic mechanism of antioxidants. Combined systolic and diastolic blood pressure change for pine bark extract group and placebo group from baseline to 6 weeks and 12 weeks. In another group of 19 american smokers, increased platelet aggregation was more significantly reduced by 200 than either 150 mg or 100 mg pycnogenol supplementation. Pinus pinaster is a type of pine tree native to france.
Co-incubation with pycnogenol resulted in a concentration-dependent inhibition of ldl oxidation. Evaluation of antioxidant activity was made using dpph and tbars test. Pine bark extracts other than pycnogenol are also sold. Most subgroups reviewed suggest an overall beneficial effect on microvascular function, particularly grape-derived products, cocoa, tea, pine bark and rutaceae aurantiae. The study’s authors suggest that pine bark extract may help stimulate circulation in the retina and inhibit swelling, which in turn may improve vision. Toyo shinyaku co, ltd provided study tablets (Toyo-fvg pine bark extract and placebo). Unlike other supplement fads, this is one herbal ingredient that may be worth following.
In another trial, 30 people with type 2 diabetes received a range of pycnogenol doses. Pyg has been suggested to protect tissues from oxidative stress-related damage in diabetes due to it’s strong antioxidant activity. The aim of this study is to investigate anticancer effect of pycnogenol in mc-3 human mucoepidermoid carcinoma (Mec) cell line. Research shows that pine bark extract is capable of reducing pro-inflammatory cytokines il-1 and il-6, responsible for many of the adverse effects of chronic inflammation. The research link between pycnogenol as a natural product of modern science and traditional pine-bark uses is evident. Compelling data from a preliminary clinical trial conducted in germany has shown improved skin elasticity and skin hydration in post-menopausal women taking just 75 mg of pycnogenol for 12 weeks. Foodpharmacy Blog and it’s editors do not advocate nutritional supplementation over proper medical advice or treatment and this sentiment will never be expressed through pages hosted under examine. I have been taking the two supplements for about a month now, and my eyes are much more comfortable and the blurring and problems in low light have diminished significantly.
Here we report the scavenging activity of pycnogenol (The polyphenols containing extract of the bark from pinus maritima) against reactive oxygen and nitrogen species, and it’s effects on no metabolism in the murine macrophages cell line raw 264,7, macrophages were activated by the bacterial wall components lipopolysaccharide (Lps) and interferon (Ifn-gamma), which induces the expression of large amounts of the enzyme nitric oxide synthase (Inos). The participants were randomly assigned to take either a japanese-produced pine-bark extract or a placebo. It is pricey, but i am glad to continue taking both of these supplements. Safety informationas with any dietary supplement, consult your healthcare practitioner before using this or any product if you are pregnant, nursing, trying to conceive, taking medication or have a medical condition. Investigators and all study staff were blinded to treatment assignment until all study results were collected, at which time the study sponsor revealed which tablet, a or b, contained pine bark extract. However, sometimes the body needs a little added support and supplemental pycnogenol can go a long way to keeping your brain and body sharp this winter. Pycnogenol is an extract of french maritime pine bark (Pinus pinaster) that consists of a concentrate of polyphenols, mainly procyanidins.
Antioxidant properties of pine bark extracts have been well described in laboratory studies and are considered to be responsible for the majority of clinical effects. The water-soluble flavonoid extract was developed, trademarked, and patented by horphag research international. Pine bark extract is rich in plant pigments called bioflavonoids. The same is true for the history of pine-bark uses, and the subsequent development and usage of contemporary pycnogenol. Fitzpatrick df, bing b, rohdewald p : Endothelium-dependent vascular effects of pycnogenol. 4 Consumption of pine needles is associated with abortion in cattle. While pycnogenol is a natural supplement, it can have powerful effects on your health, both positive and negative.
A clinical trial of 57 adhd children found that daily pycnogenol (1 Mg/kg) for one month may reduce hyperactivity symptoms. Devaraj s, vega-lopez s, kaul n, schonlau f, rohdewald p, jialal i : Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Study participants took pycnogenol as a supplement, and it was found to be most effective in women who started out with dry skin. No positive outcomes indicating that pycnogenol reduces intra-abdominal adhesions were obtained. In this paper, we review these studies in the context of understanding both biological and cognitive changes due to pycnogenol and evaluate possibilities of pycnogenol to improve neurocognitive function. Pycnogenol may increase the risk of bleeding, so it should be avoided by those with bleeding disorders, people taking blood thinning medication or supplements, or in the weeks before surgery. We therefore propose that proanthocyanidins are superior antioxidants as compared to flavon(Ol)s proper, whose quinones are more likely to redox-cycle and act as prooxidants.
Because pycnogenol lowers blood sugar, it may interact with other medications taken by people with diabetes. However, these cutaneous antioxidants can be depleted by sun exposure and environmental insults, resulting in an overload of oxidation products. Pycnogenol works as a powerful antioxidant, scavenging free-radicals and helping to stop them in their tracks. In southern france, the beautiful and lush forests are home to a species of french pine trees (Pinus pinaster) that contain unique health-promoting properties. One weakness to this study was that there was no statistical comparison between pycnogenol users and placebo treatment patients. Enzogenol, a slightly different pine bark extract, may help improve brain function after mild concussions. Consistent with our recruitment of a population with blood pressures above the normal (120/80 Mm hg) range, the mean (Sd) blood pressures at baseline were 132,6 (10,9)/78,6 (7,9) Mm hg for the pine bark extract group and 133,2 (10,9)/79,9 (7,7) Mm hg for the placebo group. Furthermore, past studies 8, 15 have shown decreases in cvd risk factors when pine bark extract was tested as an adjunct to conventional pharmacologic treatment. There is insufficient evidence to support the use of pycnogenol for any of the uses listed below. Some studies have found that supplements made from the bark can be beneficial.
G, propylgallate, beta-glucogallin, pentagalloyl glucose and tannic acid) yielded predominantly semiquinone structures derived from the parent catechol or pyrogallol moieties. As a reminder, discuss the supplements and medications you take with your health care providers. In light of this, the antioxidant mechanisms of pyc are discussed below. We also know exactly what is in pycnogenol, that it is 100 percent natural and free from pesticides and herbicides. Radiata are medium-sized pines growing up to 30 m tall with bright red-brown, deeply fissured bark. Pine bark extract can be taken either with or between meals. Remember to speak with a doctor before taking pycnogenol.
French maritime pine bark extract inhibits viral replication and prevents development of viral myocarditis. These increases were not influenced by oral consumption of pycnogenol or aspirin just before smoking. Without any treatment (Placebo) the retinopathy progressively worsened during the trial and the visual acuity significantly decreased; on the contrary, the pycnogenol-treated patients showed no deterioration of retinal function and a significant recovery of visual acuity was also obtained. Study results showed that 18 of the 24 participants who took pycnogenol had an improvement in their vision, while no such improvements were observed in those who took the placebo. Pine bark extract is generally well tolerated, with occassional minor gastric discomfort, dizziness, nausea, and headache. Pycnogenol is a trade name for a supplement derived from french maritime pine bark extract. Pycnogenol is one of the most powerful natural antioxidants. In a randomized clinical trial, liu et al 8 found that participants with hypertension taking pine bark extract (100 Mg/d) required lower doses of nifedipine to obtain normal blood pressure but did not test the effect of pine bark extract in the absence of conventional medications.
Protection from inflammation, immunosuppression and carcinogenesis induced by uv radiation in mice by topical pycnogenol.