Product name: Solgar, Pycnogenol, 100 mg, 30 Vegetable Capsules
Quantity: 30 Count, 0.11 kg, 4.6 x 4.6 x 8.4 cm
Categories: Solgar, Supplements, Antioxidants, Pine Bark Extract, Pycnogenol, Dairy Free, Casein Free, Vegetarian, Kosher Parve
Since 1947, Antioxidant Protection, Healthy Leg and Vein Support, Gluten, Wheat and Dairy Free, Suitable for Vegetarians, Kosher Parve, Dietary Supplement, Pycnogenol is the extract from the bark of the French Maritime Pine Tree, which grows in south-west France. It is a natural, concentrated source of plant-derived proanthocyanidins, a complex of naturally-occurring flavonoids and other biologically active components. Pycnogenol is an antioxidant. In addition, this unique compound supports cardiovascular health, healthy capillaries and circulation in the legs.
The most important intracellular antioxidant in the human body is glutathione (Gsh). In light of this, the antioxidant mechanisms of pyc are discussed below. These results demonstrate flavonoids participate in the cellular antioxidant network and suggest that pycnogenol may play an important role in the protection of endothelium from oxidative stress induced by reactive nitrogen species. This information relates to an herbal, vitamin, mineral or other dietary supplement. In addition, pycnogenol can help maintain your skin elasticity and hydration and slow the aging process. In the pine bark extract group, there was 1 hospitalization and no emergency department visits. Pine bark extract has been studied in a small clinical trial for pain in the third trimester of pregnancy at a dose of 30 mg/day; however, this should not be regarded as evidence of safety. The study used a randomized, placebo-controlled, double-blind clinical trial design and achieved a sample size larger than most previous studies of pine bark extract.
Solgar, Pycnogenol, 100 mg, 30 Vegetable Capsules: Pycnogenol, Pine Bark Extract, Antioxidants, Supplements
A recent study showed that pycnogenol can offer protection from the free radicals that come from the harmful rays of the sun (Photoprotection) and may also reduce hyperpigmentation of the skin, improve the skin barrier function and extracellular matrix homeostasis (The maintenance of the structure of cells and soft tissues). More research is needed to determine which individuals with hypertension may benefit from supplementation. For that reason, you should be careful taking pine bark if you have hypertension or diabetes. There is growing interest in the biologic activities of plant extracts such as that obtained from the bark of the french maritime pine pinus maritima, pycnogenol. Recent and ongoing research continues to find many more benefits that are provided by pine bark extract. Since grape extract (Ge) contains oligomeric proanthocyanidins and numerous polyphenols, dietary ge supplements may exert protective effects against various diseases. At six months, 87 percent of those who took pycnogenol were asymptomatic, compared to almost 35 percent of controls, and had significantly better blood flow in the cochlea (A part of the inner ear that plays a key role in hearing). Procyanidins are chain-like structures consisting of catechins, which confer the supplement’s antioxidant properties. According to the makers of pycnogenol, the extract has four basic properties.
Study tablets of pine bark extract contained 50 mg each and were vacuum packed in sachets with each containing 4 tablets (200 Mg). To see the full set of research information and references for pycnogenol. Clinical research suggests that pycnogenol is possibly effective for improving athletic performance. Protection from inflammation, immunosuppression and carcinogenesis induced by uv radiation in mice by topical pycnogenol. New research shows that adults over the age of 55, supplementing with pycnogenol over the course of one year, showed superior results in brain related tasks compared to placebo groups. Pinus pinaster is a type of pine tree native to france. That said, there are some instances where this extract may possibly be effective. Though it is possible that m1 is not the main mediator of maritime pine bark extract’s bioefficacy it is also conceivable that plasma is not the only compartment where m1 is present in vivo. For example, enzogenol is an extract from a pine that grows in california and mexico (Pinus radiata) that may have cognitive-enhancing effects. Toyo shinyaku co, ltd provided study tablets (Toyo-fvg pine bark extract and placebo). In a study of 20 postmenopausal women, 12 weeks of pycnogenol supplementation improved hydration and elasticity of the skin.
In short, pycnogenol is effective for enhancing and prolonging muscle performance during sport, supports muscle adaptation to higher work-load and allows for faster physical recovery. While tinnitus decreased in both groups, the decrease was more significant in those taking pycnogenol. Clinical trial results suggest pine bark extract improves skin hydration and elasticity in women. Extracts can also be made from other pine barks, such as pinus radiata, pinus densiflora, pinus thunbergii, and pinus massoniana. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect. Pine bark extract is a powerful antioxidant packed full of oligomeric proanthocyanidin compounds (Opcs). Densiflora bark extract dose-dependently prevented cataract formation. Pyc also participates in the cellular antioxidant network as indicated by it’s ability to regenerate the ascorbyl radical and to protect endogenous vitamin e and glutathione from oxidative stress. Three randomized, double-blind, placebo-controlled studies reviewed in the scientific and clinical monograph have demonstrated efficacy in treating osteoarthritis with pycnogenol. Study participants took pycnogenol as a supplement, and it was found to be most effective in women who started out with dry skin.
The fluorangiography showed an improvement of retinal vascularization and a reduced endothelial permeability and leakage in the pycnogenol, but not in the placebo-treated, patients. For most compounds second-order decay kinetics were observed, which reflect disproportionation of the semiquinones. Studies published to date about the supplement have notable methodological limitations. A study of 47 women with painful menstrual cramps who were given 30 mg pycnogenol twice a day, showed subjects had fewer days of menstrual pain when taking the product. Research suggests that pycnogenol may protect cells in the body against oxidative stress. This study and a handful of other studies have demonstrated pycnogenol as being a potential adjunct treatment for asthma. Studies have also shown that pycnogenol can have a positive effect on arthritis and osteoarthritis. Most subgroups reviewed suggest an overall beneficial effect on microvascular function, particularly grape-derived products, cocoa, tea, pine bark and rutaceae aurantiae. This clustering was in agreement with the atlantic, mediterranean and north african structuration of maritime pine established from terpene data.
French maritime pine bark extract inhibits viral replication and prevents development of viral myocarditis. This metabolite is no constituent of the extract, but is generated in vivo from the procyanidins Catechin units through multiple step reactions. However, it was found that the ultrasonic assistance increased the effect of extraction for recovery of phenolic compounds. 9, 11, 12 Pine bark extract has been reported to reduce blood concentrations of endothelin, an endothelial-derived vasoconstrictor. Consequently, i take several carefully selected supplements daily as a part of the approach to maintaining good health. In addition, although there were no previous safety concerns about pine bark extract, this study contributes to evidence about the safety of pine bark extract, including it’s effect on liver function. 24 Hence, study findings about this pine bark extract (At 200 mg/d) may not be fully applicable to other pine bark extracts or to antioxidant dietary supplements in general.
Also chemical composition varies among dietary supplements, making standardized testing difficult. Approximately 60% of patients treated with pycnogenol(R) experienced a complete disappearance of edema (The most rapidly disappearing symptom) and pain at the end of the treatment, while almost all the patients reported a reduction in leg heaviness which disappeared in approximately 33% of patients. If viva’s pycnogenol is doing this much good on the outside where i can see the improvement, how much good is it doing on the inside? Because pycnogenol lowers blood sugar, it may interact with other medications taken by people with diabetes. This review gives an overview of clinical studies demonstrating that supplementation with pycnogenol reduces platelet activity, lowers high blood pressure, relaxes artery constriction and improves blood circulation. A study of 58 patients with hypertension showed that 100 mg of pycnogenol daily had a positive effect on their blood pressure. Foodpharmacy Blog does not assume liability for any actions undertaken after visiting these pages, and does not assume liability if one misuses supplements. It was recently shown that pycnogenol (Pyc; a proprietary mixture of water-soluble bioflavonoids extracted from french maritime pine bark) was selectively toxic to established malignant ovarian germ cells. Pycnogenol supplementation reduced skin redness from uv rays in a trial of 21 people over 8 weeks. Confusion previously arose when grape seed extract was marketed as containing pycnogenol.
However, increased platelet reactivity yielding aggregation 2 hours after smoking was prevented by 500 mg aspirin or 100 mg pycnogenol in 22 german heavy smokers. In some studies, the extracted compounds are designated procyanidiol oligomers. Thus, topical antioxidants that replenish the antioxidant capacity of the skin have the potential to prevent oxidative damage. Various pharmacological effects of pcos have been reported, such as antioxidant and radical scavenging activities, reduction of capillary permeability and fragility, inhibition of destruction of collagen, and reduction of inflammation. Athletes can also benefit from the increase in no supported by pine bark extract, through enhanced circulation and blood flow. Are there known pycnogenol side effects? Pycnogenol is a patented extract of the french maritime pine bark (Pinus pinaster). Many pine bark extracts on the market are not standardized and the concentration of active components and bioactivities are hard to determine. Nhs has the exclusive rights to market and sell pycnogenol in north america and benefits from more than 35 years of scientific research assuring the safety and efficacy of pycnogenol as a dietary supplement. Participants were asked to refrain from changing their diet, losing weight, and beginning new dietary supplements or medications during the study.
Some other species such as pilea cadieri, although rich in prodelphinidin, are not suitable as sources because of the inextractability of the tannin. Our subgroup analyses of individuals with elevated baseline glucose and plasma lipid levels provide additional evidence that the pine bark extract evaluated herein does not improve these cvd risk factors. Our findings are consistent with a growing body of observational and clinical trial evidence that dietary supplements, particularly antioxidant supplementation, do not have a beneficial effect on heart disease. These results suggest that the antiinflammatory effect of pycnogenol may at least in part be due to it’s ability to modulate the gsh redox cycle and activities of catalase and superoxide dismutase. Pycnogenol contains active ingredients that can also be found in peanut skin, grape seed, and witch hazel bark. Pyc antagonizes the vasoconstriction caused by epinephrine and norepinephrine by increasing the activity of endothelial nitric oxide synthase.