Foodpharmacy Blog: Supplements, Antioxidants, Pine Bark Extract, Pycnogenol
Source Naturals, Pycnogenol Supreme, 60 Tablets
Product name: Source Naturals, Pycnogenol Supreme, 60 Tablets
Quantity: 60 Count, 0.11 kg, 5.6 x 5.6 x 10.2 cm
Categories: Source Naturals, Supplements, Antioxidants, Pine Bark Extract, Pycnogenol
Dietary Supplement, Berry and Botanical Antioxidant Complex, Pycnogenol Supreme is a power-packed antioxidant complex featuring Pycnogenol, a premium, scientifically researched pine bark extract. This synergistic formula combines Pycnogenol and a full 500 mg of vitamin C with more than 25 additional plant-derived antioxidants for the broad range of free radical protection recommended by many scientists. Together these compounds defend your tissues and cells from the oxidative stress that is so prevalent in today’s environment.
The ingredient is a combination of procyanidins, bioflavonoids and organic acids extracted from the bark of the maritime pine. However, increased platelet reactivity yielding aggregation 2 hours after smoking was prevented by 500 mg aspirin or 100 mg pycnogenol in 22 german heavy smokers. This clustering was in agreement with the atlantic, mediterranean and north african structuration of maritime pine established from terpene data. One critical point with plant extracts is always the bioavailability of their constituents. Investigators and all study staff were blinded to treatment assignment until all study results were collected, at which time the study sponsor revealed which tablet, a or b, contained pine bark extract. This dosage was selected based on the midrange of administration in past studies and the opc content of this pine bark extract compared with other formulations. Studies published to date about the supplement have notable methodological limitations. Pyc also participates in the cellular antioxidant network as indicated by it’s ability to regenerate the ascorbyl radical and to protect endogenous vitamin e and glutathione from oxidative stress.
Source Naturals, Pycnogenol Supreme, 60 Tablets: Pycnogenol, Pine Bark Extract, Antioxidants, Supplements
Pycnogenol (Pyc-nah-gen-ol) is a patented french maritime pine bark extract from horphag research. The participants were randomly assigned to take either a japanese-produced pine-bark extract or a placebo. Should i take pycnogenol or regular pine bark extract? 9 By administering a combined daily dose of pine bark extract, 480 mg, and vitamin c, 240 mg, to 24 healthy subjects in an open-label preevaluation and postevaluation, shand et al 12 found a significant decrease of 7 mm hg in the mean systolic blood pressure at 6 weeks, with a sustained decrease at 12 weeks. This review gives an overview of clinical studies demonstrating that supplementation with pycnogenol reduces platelet activity, lowers high blood pressure, relaxes artery constriction and improves blood circulation. Pycnogenol is the trade name for an extract of french maritime pine bark (Pinus pinaster). More recently, pycnogenol has been subjected to more than 100 research trials. Systolic blood pressure change for pine bark extract group and placebo group from baseline to 6 weeks and 12 weeks. It was recently shown that pycnogenol (Pyc; a proprietary mixture of water-soluble bioflavonoids extracted from french maritime pine bark) was selectively toxic to established malignant ovarian germ cells.
In a randomized clinical trial, liu et al 8 found that participants with hypertension taking pine bark extract (100 Mg/d) required lower doses of nifedipine to obtain normal blood pressure but did not test the effect of pine bark extract in the absence of conventional medications. The research link between pycnogenol as a natural product of modern science and traditional pine-bark uses is evident. In contrast, we evaluated the effects of pine bark extract as a solitary therapy, a design more likely to isolate the effect of pine bark extract. Pine bark extract has not been shown to treat or prevent cancer. Pycnogenol is similar to grape seed extract and cocoa polyphenols as those are the three most common sources of procyanidins. There is additional evidence to support that pycnogenol may be helpful in other ways for people with diabetes. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements.
One such antioxidant, pycnogenol, is a standardized plant-based extract obtained from the bark of the french maritime pine and has a long historical use to treat inflammation and improve health. The little evidence available suggests that pine bark extract may result in an improvement in the symptoms of osteoarthritis. In addition to the antioxidant activity, pycnogenol enhances production of vasodilatory endothelial nitric oxide and prostacyclin. Pine bark extract is gras, based on data from animal studies and clinical trials; however, few studies evaluate safety as a primary outcome. In addition, although there were no previous safety concerns about pine bark extract, this study contributes to evidence about the safety of pine bark extract, including it’s effect on liver function. There is absolutely no application of pesticides during the growing of the pine trees or toxic solvents during the manufacture of the french maritime pine bark extract, therefore it does not contain any pesticide or solvents. Maritime pine dieback on the west coast of france.
This paper cites several studies demonstrating that pycnogenol can improve the availability of nitric oxide, helping to maintain vascular homeostasis and improve circulation. This summer registry study confirms the clinical and microcirculatory efficacy of pycnogenol in cvi and venous microangiopathy. People with autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, lupus, and celiac disease, should probably avoid pycnogenol as it may stimulate the immune system. In this study, the antioxidant activity of several phytochemicals was compared using two different antioxidant assays: The oxygen radical absorbance capacity (Orac) assay, which measures the decrease in fluorescence decay caused by antioxidants, and the total oxyradical scavenging capacity (Tosc) assay, which measures the decrease in ethylene production caused by antioxidants. Objective: The purpose of the present study was to evaluate and compare the effectiveness of vitamin e (E) and pycnogenol (P) in treatment of chemotherapy-related oral mucositis (Chrom) in children. While pycnogenol is a natural supplement, it can have powerful effects on your health, both positive and negative. In spite of this, as an active ingredient, pycnogenol is available for purchase from many supplement companies. Pycnogenol is a mixture of flavonoid compounds extracted from the bark of pine trees. There are very few side effects associated with taking pycnogenol. Pycnogenol has recently emerged as one of the most promising dietary supplements on the market today.
Source Naturals Pycnogenol
In total, 40 patients with diabetes, atherosclerosis and other vascular diseases involving the retina were enrolled; 30 of them were treated with pycnogenol and 10 with placebo. The activity of antioxidant enzymes catalase and superoxide dismutase also increased with pycnogenol treatment. The addition of supplemental pycnogenol has been shown to offer protection from harmful uvb rays and may reduce hyperpigmentation and improve skin barrier function. A study of 53 college students, for instance, showed pycnogenol enhanced memory and focus leading to improved test scores. Today, we know that pine bark is a good source of vitamin c (The cure for scurvy) as well as numerous phytochemicals, natural plant compounds that support better health. The results indicate that pycnogenol exhibits an extensive antioxidant effect in all three in vitro systems. Pine bark extract is recommended to improve the health and smoothness of the skin, including damage caused by overexposure to sunlight. Pycnogenol is officially extracted from the french maritime pine (Pinus pinaster), which grows in the southwest coast of france. In a study of 61 adhd children, pycnogenol reduced hyperactivity, improved attention, and motorics after 1 month. In one clinical trial of 156 osteoarthritis patients, pycnogenol reduced pain, stiffness, swelling, and improved joint function after 3 months.
It appears to be relatively safe for use among children aged 6 to 18, parents wishing to supplement their children should do so only under medical supervision while staying abreast of trends. Ic50 values for the methanol extract ranged from 11,58-16,01 mg/ml for dpph and from 9,41-15,76 mg/ml for tbars assay. Pycnogenol french maritime pine bark extract is scientific evidence based and a proprietary extract, which is protected by several u. The most important intracellular antioxidant in the human body is glutathione (Gsh). The plethora of research available regarding pycnogenol suggests it has a promising future, particularly as a preventative and adjunct treatment for cvd, diabetes, and cvi. In the pine bark extract group, there was 1 hospitalization and no emergency department visits. The mixed results suggest that pycnogenol blood-pressure lowering effects may be dependent on the underlying cause of hypertension. Studies have also safely used pycnogenol in children and during pregnancy. Extracts can also be made from other pine barks, such as pinus radiata, pinus densiflora, pinus thunbergii, and pinus massoniana. The extract is subsequently compounded with excipients of palatinit sugar, caramel, sucrose, fatty acid ester, and calcium stearate. Participants were asked to refrain from changing their diet, losing weight, and beginning new dietary supplements or medications during the study.
These observations suggest an advantageous risk-benefit ratio for pycnogenol. In a nutshell, the french maritime pine bark extract comes from the bark of pinus pinaster growing on the coast of bordeaux, france. Thus, enos is closely involved in the renoprotective effects of ge, strongly suggesting that ge supplements are useful as a prophylactic treatment for the development of ischemic aki. No positive outcomes indicating that pycnogenol reduces intra-abdominal adhesions were obtained. This study and a handful of other studies have demonstrated pycnogenol as being a potential adjunct treatment for asthma. The adverse events and adverse effects questionnaire asked about symptoms commonly reported in past studies of pine bark extract, hospital and emergency department visits, new diagnoses, and changes in existing diagnoses. To see the full set of research information and references for pycnogenol. Thus, a meta-analysis was conducted to examine the effect of pycnogenol supplementation on bp. The story goes that first nations tribes shared their ancestral wisdom with cartier and used the local pine tree bark as a decoction (E.
To evaluate the efficacy and safety of orally administered grape seed proanthocyanidin extract (Gspe) in patients with non-proliferative diabetic retinopathy (Npdr). After three months, about 45 percent of those who took pycnogenol were completely asymptomatic compared to 23 percent of controls. Antidiabetic effect of pycnogenol french maritime pine bark extract in patients with diabetes type ii. Quickly and easy look up evidence on over 400 supplements across over 500 different health goals, outcomes, conditions, and more. Adverse events were reported by 43 participants in the pine bark extract group and by 42 participants in the placebo group and did not differ in severity or by specific symptom. Pine bark extract contains proanthocyanidins (Same as does pycnogenol the trade marked name for pine bark extract) which are very powerful antioxidants – up to 50 times more potent than vitamin e and 20 times more than vitamin c. Despite our extensive subgroup analysis, the only suggestion of an effect was for participants with baseline systolic blood pressure of 130 mm hg or higher, among whom the mean (Sd) lipoprotein(A) level decreased by 2 Nmol/l among 37 individuals in the pine bark extract group (Baseline level, 37 nmol/l) and increased by 4 Nmol/l among 38 individuals in the placebo group (47 Nmol/l). Pycnogenol contains active ingredients that can also be found in peanut skin, grape seed, and witch hazel bark.
Pine bark has been used as a food source in emergencies.