Sundown Naturals, Vitamin D3, 25 mcg (1,000 IU), 400 Softgels

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Product name: Sundown Naturals, Vitamin D3, 25 mcg (1,000 IU), 400 Softgels
Quantity: 400 Count, 0.11 kg, 5.6 x 5.6 x 11.4 cm
Categories: Sundown Naturals, Supplements, Vitamins, Vitamin D, D3 Cholecalciferol, Gluten Free, Dairy Free, Casein Free, Non Gmo

Gluten Free, Dairy Free, Non-GMO, Supports Bone, Teeth and Immune Health, Vitamin Supplement, Clean Nutrition, Sundown believes in clean nutrition and being transparent. That’s why you won’t find genetically modified ingredients, gluten, wheat, dairy, lactose or artificial flavors in any of our products.

Vitamin d3 may be more than three times as effective in raising concentrations of vitamin d in the bloodstream and maintaining those levels for a longer time. Recent cochrane reviews on pain 9 and fractures 10 have addressed the effects of vitamin d supplementation. Healthy volunteers were given a single 50,000 unit dose of either vitamin d2 (Ergocalciferol) or vitamin d3 (Cholecalciferol) why is ergocalciferol prescribed? Breastfeeding: Infants who exclusively breastfeed need a vitamin d supplement, especially if they have dark skin or have minimal sun exposure. Most studies have found a decrease in general symptoms when given to women with vitamin d deficiency, some finding notable reductions and some finding small reductions. Review: The impacts of circulating 25-hydroxyvitamin d levels on cancer patient outcomes: A systematic review and meta-analysis. It’s unclear whether vitamin d3 might harm your unborn baby. In addition, giving vitamin d supplements to people at risk of deficiency has been found to reduce the risk of multiple sclerosis and certain cancers, and prevent falls in the elderly.

Sundown Naturals, Vitamin D3, 25 mcg (1,000 IU), 400 Softgels: D3 Cholecalciferol, Vitamin D, Vitamins, Supplements

Vitamin d agonists (Vdras) are vasculotropic hormones, and vitamin d insufficiency is associated with significant, undesirable changes in cardiovascular physiology and structure. Genetic evidence that the human cyp2r1 enzyme is a key vitamin d 25-hydroxylase. Even seafood would have enough natural fat to help with vitamin d absorption. I suffer from depression and have recently learned i have low vitamin d, after a course from the doctor, my motivation and energy levels improved so have continued taking them. 88 Studies have suggested that magnesium could influence pth synthesis and determine the number of vitamin d receptors; therefore, a deficiency in magnesium levels may lead to diminished synthesis and secretion of pth and a reduced number of available vitamin d receptors in the target cells. However, sun exposure rarely provides adequate vitamin d, making it necessary to obtain it from supplements or your diet. Phytoplankton in the ocean (Such as coccolithophore and emiliania huxleyi) have been photosynthesizing vitamin d for more than 500 million years.

We found two main areas of interest: The vitamin d deficiency status in patients affected by gh deficit (Ghd) and the relationship between serum vitamin d metabolites and igf-1, although limited by some bias, from the analysis of the studies presented in the scientific literature, it is possible to hypothesize a greater frequency of hypovitaminosis d in the subjects affected by ghd, a reduced possibility of it’s correction with only substitution treatment with recombinant growth hormone (Rgh) and an improvement of igf-1 levels after supplementation treatment with vitamin d. It appears that at nutritional doses vitamins d2 and d3 are equivalent, but at high doses vitamin d2 is less potent. You may also see d supplements with added magnesium, which helps metabolize d. Vitabright vitamin d3 has natural ingredients and i like that they are sourced responsibly and made in the uk. The vitamin d council recommends 5,000 iu daily. The conversion of calcifediol to calcitriol is catalyzed by the enzyme 25-hydroxyvitamin d 3 1-alpha-hydroxylase, which is the product of the cyp27b1 human gene. You need to take magnesium in order for vitamin d to work well. Mushrooms exposed to ultraviolet light contribute useful amounts of vitamin d. Vitamin d 3 formed in this fashion as well as vitamin d 3 and d 2 taken from dietary sources or commercially available supplements circulate in the bloodstream bound to the dbp. Vitamin d is completely different than most other vitamins.

Both these versions of vitamin d require processing by the liver and kidneys. In the eye, initial studies in mouse, rabbit, and human corneal epithelial cells showed expression of vdr and cyp27b1 by rt-pcr, and vitamin d metabolites were detected in the aqueous and vitreous humors by mass spectroscopy. He routinely tests his patients twice a year to determine if their vitamin d level changes from summer to winter. Primitive vertebrates in the ocean could absorb calcium from the ocean into their skeletons and eat plankton rich in vitamin d. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. Came across the nutravita vitamin d3 4,000 iu, it peaked my interest. Effect of calcium and vitamin d supplementation on bone mineral density in children with inflammatory bowel disease. In addition, people who have darker skin need more sun exposure to produce adequate amounts of vitamin d, especially during the winter months. Vitamin d and vitamin d analogues for preventing fractures in post-menopausal women and older men. Additional studies are needed to determine the potential fracture risk posed by high-dose vitamin d, particularly in patients at risk for fractures and osteoporotic changes. Ideal form of vitamin d supports maintenance of healthy bones and teeth, cellular function and proper functioning of the immune and nervous systems. Due to the many health benefits of vitamin d, supplementation is encouraged if optimal levels are not present in the body.

We liked the short list of ingredients: 2,000 Iu of vitamin d3 (As cholecalciferol, which mimics the way the body naturally processes vitamin d), soybean oil (Rich in heart-healthy polyunsaturated fats), plus gelatin, glycerin, and water for the softgel capsule. If you experience any adverse condition after taking this dietary supplement, discontinue use immediately and consult your health care provider. Adherence to the supplementation regimen was surely a strong source of between-trial variability, but few trials reported data on adherence to supplementation, which was often difficult to compare. People can measure vitamin d intake in micrograms (Mcg) or international units (Iu). Because i buy so many supplements in powder form, i purchased a milligram scale on ebay. I went away for a short holiday and forgot to take with me my 400microgram vitamin d3 supplement tablets. Supplemental vitamin d is associated with a wide range of benefits, including increased cognition, immune health, bone health and well-being. The d vitamin is the only vitamin that is not obtained from foods that are consumed.

Sundown Naturals D3 Cholecalciferol

Therefore, alternative explanations for the increase in cognitive impairment exist and hence a direct causal relationship between vitamin d levels and cognition could not be established. Moreover, recent studies in infants raise a potential need for monitoring vitamin d levels when doses at or above the currently recommended upper range are used. If possible, it’s better to get your vitamin d from food sources rather than supplements (See selected food sources of vitamin d. British doctor edward mellanby noticed dogs that were fed cod liver oil did not develop rickets and concluded vitamin a, or a closely associated factor, could prevent the disease. My grandmother was taking a daily dose of 1k for years per her doc, and when someone finally tested her levels her vitamin d was only in the teens. Doctor said the wife was very low on vitamin d and suggested vitamin d pills but we went for this instead. Less common causes of vitamin d deficiency include familial or acquired diseases that impair the enzymes in the liver or kidney that create the biologically active form of the vitamin. An estimated 41% of us adults are vitamin d-deficient, and that has serious long-term effects. Insulin-like growth factor i, growth hormone, and insulin sensitivity: The effects of a one-year cholecalciferol supplementation in middle-aged overweight and obese subjects.

More research is needed to understand the vitamin d-gh biological interaction in other diseases characterized by short stature. However, at intakes closer to those prevailing during hominid evolution, minor shifts in vitamin d mediated absorption are fully adequate to compensate for stresses on the calcium economy. For most people, sensible sun exposure is the easiest way to increase your vitamin d levels. Magnesium is naturally found in many foods, is available as a dietary supplement, and is present in such medicines as antacids and laxatives. Can supplementation with vitamin d reduce the risk or modify the course of autoimmune diseases? Subclinical vitamin d deficiency or vitamin d insufficiency is common and is defined as a lower than normal vitamin d level that has no visible signs or symptoms. Hence, the possibility cannot be dismissed that, because of dosage and compliance problems, changes in vitamin d status in the whi trial might not have been sufficient for observing a substantial influence on the risk of colorectal cancer. As far as i know, there is no high-quality research evidence indicating that supplementing an older person up to a vitamin d level of 50-60 (As compared to 20-40) is better for osteoporosis outcomes. Stability of vitamin d in foodstuffs during cooking. Role of vitamin d in diabetes mellitus and chronic kidney disease. Human beings require and source vitamin d from diet, dietary supplements and exposure to sunlight. However, most adults are unlikely to get more than 5-10% of their vitamin d needs from dietary sources.

Decided to go with nutribioticals as i also take their vitamin b12 suppliments and they are very easy on the tummy. Discouraging testing for vitamin d deficiency is way up in the united states, but recent studies find that supplements of the nutrient may do less than expected. Of the two, d3 (Cholecalciferol) seems to be almost twice as effective at increasing blood levels of vitamin d as d2 (Ergocalciferol) (6, 7). Bacon et al Showed similar improvements in the sustainability of 25(Oh)d concentrations in the long-term by adding monthly 50,000 iu vitamin d 3 doses following an initial 500,000 iu vitamin d 3 bolus. More recently, a number of trials in healthy children tested vitamin d doses at the upper levels set by the iom and with the goal of increasing serum concentrations above 30 ng/ml. Of note, supplementation with 1,000 iu daily is thought to increase serum 25(Oh)d by 10 ng/ml. This question is, however, crucial for setting dietary recommendations as well as for determining up to which point randomized trials testing the ability of vitamin d to prevent chronic diseases occurring for the most part after 50 yr of age actually improved the vitamin d status of subjects allocated to intervention groups.

Basically, to synthesize vitamin d through the skin, one has to get sunlight during the peak hours close to midday, because the type of uv radiation that sparks vitamin d synthesis is scattered by the atmosphere. I know that some health providers recommend substantially higher vitamin d levels, but as best i can tell, there is no high-quality research evidence to support this. All of this means that it can be tricky to get enough sun exposure to maintain vitamin d levels (Especially in the winter or if one is dark-skinned). The vitamin d receptor represses transcription of the pituitary transcription factor pit-1 gene without involvement of the retinoid x receptor. Cholecalciferol supplementation alters gut function and improves digestibility in an underground inhabitant, the naked mole rat (Heterocephalus glaber), when fed on a carrot diet. 14 The effects of vitamin d supplementation on circulating levels of magnesium were investigated in patients with type 2 diabetes mellitus. For example, a person with a serious illness may have a vitamin d deficiency.