Product name: Superior Source, Vitamin K-2, 100 mcg, 60 Microlingual Instant Dissolve Tablets
Quantity: 60 Count, 0.05 kg, 4.1 x 4.1 x 8.9 cm
Categories: Superior Source, Supplements, Vitamins, Vitamin K, Non Gmo
GMO Free, MK-7, MicroLingual Instant Dissolve Tablets, Dietary Supplement, Our Instant Dissolve MicroLingual Tablets may be small but they are full potency! Typical tablets and capsules need to be swallowed and are inefficiently absorbed in the digestive system. MicroLingual tablets dissolve immediately under the tongue heading straight into the body. Our proprietary hydrodrying process results in fewer inactive binders and fillers and a higher ratio of nutritional ingredients—hence the small size. They efficiently provide your body with the nutrients you need right now, “Less is More”, Simplicity Purity Efficiency, No pills to swallow, Place on or under the tongue, Dissolves on contact, GMO and preservative free, Chewing leads to smooth and better absorption.
Rapidly elevated transient calcium levels in blood caused by excessive supplementary calcium have been suggested to promote coagulation when compared with placebo in postmenopausal women, likely due to interaction with platelets expressing calcium-sensing receptor (Casr) (140, 141). Dietary induced subclinical vitamin k deficiency in normal human subjects. The richest source of vitamin k2 (Mk-7) is a japanese dish named natto, which is produced from fermented soy beans with aid of the bacillus subtilis bacteria strain. All studies but 1 showed an advantage of phytonadione and menaquinone-4 in terms of bmd. Mk-4, mk-7, and mk-9 are the most well-studied menaquinones. Osteocalcin (Also known as bone gla protein) is synthesized by osteoblasts (Bone-forming cells); the synthesis of osteocalcin is regulated by the active form of vitamin d, 1,25-dihydroxyvitamin d (Calcitriol). Vitamin d3 and k2 supplements are available as either capsules, drops or powder.
Superior Source, Vitamin K-2, 100 mcg, 60 Microlingual Instant Dissolve Tablets: Vitamin K, Vitamins, Supplements
Certain individuals within the population are at a much higher risk of suffering from a hypovitaminosis (Lack) of vitamins d3 or k3 than the general population. Although circulating dp-ucmgp was correlated to various markers of vitamin k status, no association with measures of coronary artery calcification were found. It is one of the four fat-soluble vitamins, along with vitamin a, vitamin d, and vitamin e. Dietary vitamin k is protein-bound and is liberated by the proteolytic action of pancreatic enzymes in the small intestine. These studies highlight the importance of vitamin k in various health disorders, and should lead in turn to clinical interventions to improve the condition of patients with these health disorders. Pleiotropic effects of vitamin d on osteoblast gene expression are related to the proliferative and differentiated state of the bone cell phenotype: Dependency upon basal levels of gene expression, duration of exposure, and bone matrix competency in norma. Routine supplementation, however, is not justified until these results are confirmed in a large pragmatic rct with fractures as the main outcome. Research results suggest that the use of vitamin k is potentially beneficial in attenuating the progression of vascular calcification and several outcome trials are currently underway. Free range chicken eggs, for example, contain a larger amount of vitamin k2 than barn-laid chicken eggs. Some vegetable oils, notably soybean oil, contain vitamin k, but at levels that would require relatively large calorie consumption to meet the recommended amounts.
More evidence on the combined role of vitamin k antagonist use and vitamin d on bone and cardiovascular health is urgently needed. All data in this review (And it’s supplementary information document) are available for public use without any restriction. Furthermore, we can assure you that everything that is on our label is consistent with what goes into our vitamins and supplements. In recognition of the promise of vk2 on reducing the risk of heart disease, the international life science institute (Ilsi europe) recommends that the amount of vk2 be considered in addition to vk1, when calculating the daily recommended value of vitamin k. 2 13 Despite the fact that a high percentage of undercarboxylated osteocalcin indicates poor vitamin k status, this value can also vary based on recent vitamin k intake and supplementation 2 14 and may not indicate chronic vitamin k status. This article reviews recent research and advances in vitamin k biochemistry and metabolism that have been made over the last five years, with special focus on the functions of vitamin k recycling and mk4 synthesis. Genetic, molecular, cellular, and human evidence support that optimal concentrations of both vitamin d and vitamin k are beneficial for bone and cardiovascular health. Improvements in skin and whiter teeth can result from vitamin k supplementation.
More high-quality, controlled studies are needed to further investigate the effects of both vitamin k1 and k2 on bone health and determine whether there are any real differences between the two. Sufficient quantities of vitamin k in the body are necessary for the activation of these proteins in the body to take place, which then allows the proteins to bind calcium, and to move it around, and to function as an essential regulator of calcium and magnesium metabolism within the body, and specifically in bones, the heart, the arteries, the kidneys, teeth, etc. Available data suggest that supplement doses of vitamin k2 (Mk-7), but not vitamin k1, promote healthy bone. Earlier observational studies offer limited support to an inverse relationship between phylloquinone intake and risk of cvd, despite high intakes being sometimes regarded as a marker of healthy dietary habits associated with low cardiovascular risk (Reviewed in 77). If you wish to check foods for their nutrient content, including phylloquinone, search usda’s fooddata central. There was no significant difference between the vitamin d and mineral group without vitamin k and the placebo group. Koncentrated k is in the form of a capsule that is formulated with vitamin k1, mk7, mk4, and astaxanthin which is considered to the be the best anti-oxidant available.
Summary vitamin k2 plays an essential role in bone metabolism, and studies suggest that it can help prevent osteoporosis and fractures. This would give valuable insight if vitamins d and k are involved in developing cardiovascular disease. For example, cooked spinach has a 5% bioavailability of phylloquinone, however, fat added to it increases bioavailability to 13% due to the increased solubility of vitamin k in fat. The discovery of vitamin k and it’s clinical applications. We propose a new hypothesis that if vitamin d concentrations are constantly high, there might not be enough vitamin k for activation of vitamin k-dependent proteins. The factors involved in the regulation of calcification are being studied, including matrix gla protein (Mgp) and vitamin k2 or menaquinones. An inverse relationship between vitamin k intake and mortality was reported in a us national survey (Nhanes iii) of 3,401 participants. Matrix gamma-carboxyglutamate (Gla) protein (Mgp) is a vitamin k-dependent protein and a strong inhibitor of vascular calcification. If vitamin k absorption appears to be reduced by other fat-soluble vitamins, like vitamin d, why do some bone health supplements combine them? Vitamin k2 (Menaquinone) is produced by bacteria in both animal and human intestines.
Superior Source Vitamin K
I have never supplemented with calcium, assuming i got enough in my raw milk. Epoxide reductase, one of the key enzymes in the vitamin k cycle, was strongly inhibited by warfarin, whereas it was not affected by 1,25(Oh)d, meaning that the vitamin k metabolic cycle functions normally in human osteoblasts. An additive effect was noticeable for decreased percentage of uncarboxylated osteocalcin, which indicates an improved vitamin k status in the treatment group. Abnormal clotting is not related to excessive vitamin k intake, and there is no known toxicity associated with vitamin k 1 or vitamin k 2 (See toxicity). 2 Worldwide, the food richest in vitamin k2 is soybeans fermented with the bacterium bacillus subtilis. Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat. Although allergic reaction from supplementation is possible, no known toxicity is associated with high doses of the phylloquinone (Vitamin k 1) or menaquinone (Vitamin k 2) forms of vitamin k, so no tolerable upper intake level (Ul) has been set. Furthermore, among those with coronary artery calcification at baseline, phylloquinone treatment reduced calcification progression by 6% compared to the control group. Maternally administered antenatal vitamin k1: Effect on neonatal prothrombin activity, partial thromboplastin time, and intra-ventricular hemorrhage.
Several observational studies have suggested that vitamin k2 is better than k1 at reducing these calcium deposits and lowering your risk of heart disease (18, 19, 20). It has several subtypes called menaquinones (Mks) that are named by the length of their side chain. Adults at risk for vitamin k deficiency include those taking vitamin k antagonists and individuals with significant liver damage or disease. The realm of vitamin k dependent proteins: Shifting from coagulation toward calcification. The mode of action of vitamin k identification of gamma-carboxyglutamic acid as a component of prothrombin. Mk-5 through mk-15 are forms of vitamin k2 with longer side chains. It is important for people taking these medications to consume the same amount of dietary vitamin k each day and to speak to a doctor before taking supplements or making dietary changes.
All participants also received daily supplements containing 630 mg calcium and 400 iu vitamin d3, at the end of the study, participants receiving either phylloquinone or mk-4 had significantly lower levels of undercarboxylated osteocalcin compared to those receiving placebo. A: The bottle reads: Vitamin k2 (As menaquinone) also: 2 Mg vitamin c (From ascorbyl palmitate) and 300 mg alfalfa. Several widely available foods are rich sources of vitamin k1, but vitamin k2 less common. A broad amount of data seems to indicate substantial potential for supplementary vitamin k. The function of phylloquinone in plants appears to have no resemblance to it’s later metabolic and biochemical function (As vitamin k ) in animals, where it performs a completely different biochemical reaction. Combining high-potency, natural-source d-3 cholecalciferol with a clinically supported serving size of k-2 menaquinone-7 from fermented chickpea, solaray vitamin d3 and k2 is formulated to help your body transport and absorb calcium, thus helping to support healthy bones and teeth. For instance, it appears that vitamin k helps to regulate calcium in both bone and the arteries, through gla. This study associated higher phylloquinone intakes, but not menaquinones, with lower risk of all-cause mortality. If you are wondering why your physician has not suggested that you take vitamin k or vitamins in general, it is due to the fact that the current state of medical education and practice is heavily focused on poly-pharmacy which is the prescribing of multiple synthetic drugs as a primary mode of treatment.
Vitamin d promotes the production of vitamin k-dependent proteins, as shown in rats by karl et al. Summary of clinical trials of combined vitamin d and k supplementation on bone health. The benefit of vitamin k on bone is thought to be unrelated to increasing bmd but rather increasing bone strength. Other populations with an increased prevalence of vitamin k deficiency include those who suffer from liver damage or disease (E. Some observational studies support the hypothesis that optimal concentrations of both vitamins d and k support bone mineralization and lower fracture risk. It contains a ton of vitamin c, vitamin k (Which helps to reduce inflammation) and is a great source of fiber, magnesium and potassium. Future studies are needed to determine whether vitamin d combined with vitamin k rich foods or vitamin k supplementation could improve bone and cardiovascular health. Vitamin k is given as an injection to newborns to prevent vitamin k deficiency bleeding.
Lehvoss nutrition offer a range of natural, organic certified, vegan and active vitamins and minerals. About one-third of adults in the us have vitamin k intake in their diet that is lower than the adequate intake levels, which has raised some concern about dietary sources of vitamin k. The body needs vitamin k to produce prothrombin, a protein and clotting factor that is important in blood clotting and bone metabolism. A review that summarized currently available evidence implicating vitamin k in the pathogenesis of vascular calcification (Vc), in particular arterial medial calcification. These side effects should dissipate gradually, once your body gets used to digesting the supplement.