Product name: Thorne Research, R-Lipoic Acid, 60 Capsules
Quantity: 60 Count, 0.05 kg, 5.1 x 5.1 x 10.2 cm
Categories: Thorne Research, Supplements, Antioxidants, Alpha Lipoic Acid, Gluten Free
Dietary Supplement, Brain/Nerves, Liver/Detox, Gluten Free, The most active form of alpha-lipoic acid to support healthy nerve and brain function, R-Lipoic Acid is the most active isomer of alpha-lipoic acid, which is a versatile antioxidant. It has important characteristics that contribute to liver, nerve, and eye health, Alpha-lipoic acid occurs naturally as a 50/50 mixture of R-lipoic acid (R-ALA) and S-lipoic acid (S-ALA). R-lipoic acid by itself functions as an essential cofactor for many enzymes involved in energy production. It also has characteristics, including significant antioxidant effects, that contribute to liver, brain, nerve, and eye health. Studies indicate that supplements containing only R-lipoic acid appear to be better absorbed than supplements containing both R-lipoic acid and S-lipoic acid, with results showing twice as much ALA appearing in the bloodstream after an oral dose of R-Lipoic acid. Because R-Lipoic acid is the form best utilized by the body, Thorne provides R-lipoic acid bound to sodium, providing it in its most stable, absorbable form, Alpha-lipoic acid, also known as thioctic acid, was discovered in 1951 as a molecule that assists in acyl-group transfer and as a coenzyme in the Krebs Cycle. In the 1980s, the scientific community realized that.
My husband was advised to try alpha lipoic acid to help with pain and numbing caused by multiple sclerosis and he believes it is helping. (R)-, but not s-alpha lipoic acid stimulates deficient brain pyruvate dehydrogenase complex in vascular dementia, but not in alzheimer dementia. Now back on track with several suppliments (Alpha lipoic acid being one of the main essentials) and a change of diet i am starting to feel more energised and in control. The effect of lipoic acid on eae has been evaluated in many studies. Most antioxidants are either fat or water-soluble. If you choose to use supplements, the linus pauling institute recommends a daily dose of 200 to 400 mg/day for generally healthy people. Research shows that (R)-lipoic acid is a more biologically active form of ala that offers greater antioxidant and neuroprotective benefits at substantially lower doses than the synthetic forms of lipoic acid currently available. Studies have also discovered that alpha-lipoic acid may ease symptoms of diabetic neuropathy, which is nerve pain caused by uncontrolled diabetes (14, 15). The antioxidant properties of alpha-lipoic acid have been linked to several benefits, including lower blood sugar levels, reduced inflammation, slowed skin aging, and improved nerve function. Few studies have reported the beneficial effects of antioxidant supplementation on inflammatory cytokines.
Thorne Research, R-Lipoic Acid, 60 Capsules: Alpha Lipoic Acid, Antioxidants, Supplements
For use in dietary supplement materials and compounding pharmacies, the usp has established an official monograph for r/s-la. They discovered that in addition to being a powerful antioxidant in it’s own right, ala is able to raise intracellular glutathione levels. Plasma kinetics, metabolism, and urinary excretion of alpha-lipoic acid following oral administration in healthy volunteers. As with all dietary supplements, keep out of reach of children. We estimated the difference between intervention (Ala supplementation) and placebo group by calculating the standardized mean difference (Smd) with 95% confidence interval (Ci) using stata software version 12,0 (Stata corp, college station, tx) and revman v. Dose/response curves of lipoic acid r-and s-forms in the working rat heart during reoxygenation: Superiority of the r-enantiomer in enhancement of aortic flow. One placebo-controlled study examined the effect of lipoic acid on the visual capability of 80 participants of whom 12 had type 1 diabetes, 48 had type 2 diabetes, and 20 were diabetes-free. Alpha-lipoic acid as a biological antioxidant. Some evidence from small randomized controlled studies suggests that high-dose lipoic acid may improve measures of glucose utilization in subjects with metabolic disorders. In europe, some researcher have found that lipoic acid can have a positive effect on long term memory in older mice.
A placebo-controlled study of 72 patients with type 2 diabetes found that oral administration of lipoic acid at doses of 600 mg/day, 1,200 mg/day or 1,800 mg/day improved insulin sensitivity by 25% after four weeks of treatment. Alpha lipoic acid is considered an important antioxidant? Neuroprotection by the metabolic antioxidant alpha-linoic acis. A rare cause of status epilepticus; alpha lipoic acid intoxication, case report and review of the literature. Lipoic acid occurs naturally in food covalently bound to protein, whereas supplements contain unbound (Free) lipoic acid. Whenever i take a supplement i always read the independent research papers which are often hard to find. Thus, the current meta-analysis was performed to summarize the available evidence regarding the effect of ala supplementation on inflammatory markers among patients with mets and related disorders. In this review we briefly summarize the known biochemical properties of lipoic acid and then discussed the oxidative mechanisms implicated in diabetic complications and the mechanisms by which lipoic acid may ameliorate these reactions.
It is not certain whether alpha-lipoic acid is effective in treating any medical condition. 98 Moreover, a lipophilic complex of lipoic acid with the cupric ion has been invoked to explain protection against cupric ion-induced lipid peroxidation. As a dietary supplement for adults, take one Or two Softgels daily, preferably on a empty stomach, or as directed by your healthcare practitioner. Alpha-lipoic acid (Ala) has been used as a dietary supplement at different doses in patients with diabetes mellitus type 2 (T2dm) due to it’s antioxidant, anti-inflammatory, and hypoglycemic effects. Alpha-lipoic acid may have been combined with other plants or extracts in a specific preparation to treat these conditions. Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase. Alpha lipoic acid, a naturally occurring dithiol compound which plays an essential role in mitochondrial bioenergetic reactions, has gained considerable attention as an antioxidant for use in managing diabetic complications. Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Moreover, alpha-lipoic acid raises the levels of other antioxidants, such as glutathione, which help protect against skin damage and may reduce signs of aging (21, 22). Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination. The eye health supplement to help people with occasional dry eye produce more natural tears with a greater level of lubrication to relieve associated eye discomfort and irritation.
Alpha-lipoic acid is also considered an antioxidant, meaning that it can neutralize harmful compounds called free radicals that damage cells at the genetic level. Alpha- lipoic acid (1,2-Dithiolane-3-pentanoic acid; ala), also known as thioctic acid, is an endogenous thiol antioxidant possessing powerful potential to quench reactive oxygen species, regenerate gsh, and chelate toxic metals. The many unique properties of ala and it’s interaction with other important antioxidant such as vitamin e, ascorbate, and gsh provide a fertile field for continued research. First, antioxidant properties allow alpha-lipoic acid to neutralize free radicals and reduce oxidative stress, which is linked to damage that can increase heart disease risk. However, human studies show that alpha-lipoic acid only slightly impacts weight loss. An analysis of 12 studies discovered that people who took an alpha-lipoic acid supplement lost an average of 1,52 pounds (0,69 Kg) more than those taking a placebo over an average of 14 weeks. Alpha-lipoic acid is not the same as alpha linolenic acid, which is an omega-3 fatty acid that may help heart health. In cells, lipoic acid is swiftly reduced to dihydrolipoic acid, and in vitro studies indicate that dihydrolipoic acid is then rapidly exported from cells. What does alpha lipoic acid do for the body?
Thorne Research Alpha Lipoic Acid
It is believed by some that alpha-lipoic acid, given in large enough doses, can counter this stress by exerting potent antioxidant activity. Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (Alpha-lipoic acid): A two year multicenter randomized double-blind placebo-controlled trial (Aladin ii). Alpha-lipoic acid is found in low amounts in foods such as spinach, broccoli, potatoes, carrots, beets, and red meat. In cells, it works to regenerate antioxidants such as glutathione, vitamin c, and vitamin e, while also taking part in mitochondrial energy production. The present study revealed that supplementation with ala slightly but significantly decreased body weight and bmi. Alpha lipoic acid ir is an immediate-release softgel, which rapidly releases ala to promote optimal absorption, especially when taken as directed on an empty stomach. These diverse actions suggest that lipoic acid acts by multiple mechanisms, many of which have only been uncovered recently. The results demonstrated that lipoic acid suppressed eae possibly through modulation of the immune system and inflammatory responses.
Lipoic acid serves as co-factor to the acetoin dehydrogenase complex catalyzing the conversion of acetoin (3-Hydroxy-2-butanone) to acetaldehyde and acetyl coenzyme a. The antioxidant alpha-lipoic acid improves endothelial dysfunction induced by acute hyperglycemia during ogtt in impaired glucose tolerance. I think this supplement helped me with that! With respect to the antioxidant capacity of ala, it has been pointed out that it is a powerful redox pair that is capable of neutralizing different ros. Meta-analyses of randomized controlled trials suggest that infusion of 300 to 600 mg/day of lipoic acid for two to four weeks significantly reduced the symptoms of diabetic neuropathy to a clinically meaningful degree (55, 74). Alpha-lipoic acid improves subclinical left ventricular dysfunction in asymptomatic patients with type 1 diabetes. As a dietary supplement for adults, take one Capsule daily with a meal, or as directed by a physician. Lester packer, senior scientist at lawrence berkeley laboratory and head of the packer lab at the university of california, has spent over 35 years studying how antioxidants like vitamins c, e and glutathione interact in the body. Consult with your personal physician before taking any supplement, and do not exceed recommended doses. Further to the effects of la on nrf-2-mediated antioxidant gene expression, la has also been shown to modulate peroxisome proliferator activated receptors (Ppars)-regulated genes.
However, only a handful of studies have investigated alpha-lipoic acid and memory loss-related disorders. Specifically in diabetes, it prevents beta cell destruction, enhances glucose uptake, and it’s antioxidant effects may be particularly useful in slowing the development of diabetic complications such as diabetic neuropathy. Effects of dl-alpha-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy. There was no reduction in waist circumference with supplemental lipoic acid (5 Studies). Some of the more expensive products were made with r-isomer-only alpha lipoic acid, which has both pros and cons. Role of alpha-lipoic acid in the management of anemia in patients with chronic renal failure undergoing hemodialysis. Alpha-lipoic acid prevents buthionine sulfoximine-induced cataract formation in newborn rats. Ala is not only an antioxidant in it’s own right, protecting cells from oxidative damage, it also reduces, and thereby recycles, oxidized forms of other powerful antioxidants, such as glutathione, vitamin c, vitamin e, and coq10 so they too can continue to scavenge reactive oxygen species.
The non-accidental ingestion of a very high dose of lipoic acid led to multi-organ failure and subsequent death of an adolescent girl. Although lipoic acid does not chelate the ferric ion, 97 it has been shown to form a complex with the ferrous ion. Summary though alpha-lipoic acid has properties that may promote weight loss, it’s overall effect in humans seems negligible. Available information regarding the effects of ala supplementation on inflammatory cytokines is inconclusive. I read online that alpha lipoic acid helps stabilize your blood sugar and i noticed that i felt some energy with it during the day and my appetite was lessened. In addition to the physiological functions of protein-bound lipoic acid, there is increasing scientific and medical interest in potential therapeutic uses of pharmacological doses of free (Unbound) lipoic acid.