Thorne Research, Vitamin K2, 1 fl oz (30 ml)

$51.80

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Product name: Thorne Research, Vitamin K2, 1 fl oz (30 ml)
Quantity: 1 fl oz, 0.08 kg, 3 x 10.2 x 3 cm
Categories: Thorne Research, Supplements, Vitamins, Vitamin K

Dietary Supplement, Vitamin K2 in its MK-4 form to support bone, heart, and blood vessel health, Vitamin K2 (as MK-4) exerts a more powerful influence on bone health than vitamin K1. K2 also supports heart and blood vessel health. It comes in a metered bottle for ease of use, Vitamin K2 offers significant benefit for supporting bone health – more than vitamin K1. Although vitamin K2 offers well-recognized postmenopausal bone support, because it has no estrogenic effects it also provides support to other populations as well, including anorexics, dialysis patients, individuals with Parkinson’s disease, those who have cirrhosis of the liver, individuals who have had a bone marrow transplant, those immobilized after a stroke, and individuals on chronic steroid therapy. Vitamin K2 also supports a healthy heart and blood vessels. Thorne’s vitamin K2 supplies 1 mg of vitamin K2 per drop. Research shows that 15 mg three times daily can be safely used. The concentrated liquid and the bottle’s metered dispenser make use easy and convenient.

Table from important information to know when you are taking: Warfarin (Coumadin) and vitamin k, clinical center, national institutes of health drug nutrient interaction task force. There is some intriguing evidence that menaquinone-4 may possess other antiosteoporotic properties that are specifically associated with the geranylgeranyl side chain of this k 2 vitamin. From a clinical perspective, the results of this review suggest that patients at risk for fracture should be encouraged to consume a diet rich in vitamin k, which is chiefly obtained from green leafy vegetables and certain vegetable oils. Koncentrated k is in the form of a capsule that is formulated with vitamin k1, mk7, mk4, and astaxanthin which is considered to the be the best anti-oxidant available. A recent review summarizing the use and efficacy of calcium supplementation in treating osteoporosis and fracture risk questions the use of calcium supplements because of the weak beneficiary effect on fracture risk while increasing the risk on gastrointestinal problems, kidney stones, and cardiovascular risk. Certain vitamin d3 and k2 supplements can contain minerals like calcium, phosphorus or magnesium. Research results suggest that the use of vitamin k is potentially beneficial in attenuating the progression of vascular calcification and several outcome trials are currently underway. Abnormal clotting is not related to excessive vitamin k intake, and there is no known toxicity associated with vitamin k 1 or vitamin k 2 (See toxicity).

Thorne Research, Vitamin K2, 1 fl oz (30 ml): Vitamin K, Vitamins, Supplements

It provides 500 micrograms of vitamin k2 in the mk-4 form as well as an additional 100 micrograms in the mk-7 form, so it might be more biologically active than single-form vitamin k supplements. Us pharmacopeia considers vitamin k2 supplementation to be safe. Vitamin k refers to a family of fat-soluble vitamins that the body needs to produce a protein called prothrombin, which promotes blood clotting and regulates bone metabolism. As with most supplements, also calcium-containing phosphate binders have side effects, which include abdominal cramps, intestinal bloating, and diarrhea. Preliminary clinical research indicates that deficiency of vitamin k may weaken bones, potentially leading to osteoporosis, and may promote calcification of arteries and other soft tissues. Research has shown that too little vitamin k is associated with various age-related concerns, such as cognitive function, heart health, and mobility. Vitamin k-containing dietary supplements: Comparison of synthetic vitamin k1 and natto-derived menaquinone-7, blood. If you decide to take this product, make sure you think about a separate d3 supplement in case you are deficient. Some scientists have suggested that the roles of vitamins k1 and k2 are quite different, and many feel that they should be classified as separate nutrients altogether.

K complete is a great option to cover all of our bases for vitamin k requirements. Low levels of vitamin k impair activation of osteocalcin and decrease the activity of osteoblasts (Cells important for building bone). I am curious about the estrogenic effects of these k2 supplements. All are active, but one, the mk-7 form of vitamin k2, can increase blood levels of vitamin k up to 8 times as much as other forms. Researchers subsequently identified gut bacteria as a major driver of vitamin k2 conversion (From k1). Dietary phylloquinone depletion and repletionin older women. After 10 weeks, treatment with vitamin k had normalized blood glucose and reduced symptoms of anxiety and depression. The effect of a vitamin d3 deficiency can be somewhat difficult to identify, becasue it causes a feeling of tiredness and a general feeling of malaise, which are fairly vague symptoms. It can be challenging to find vitamin d3 and k2 supplements for vegans and vegetarians.

Earlier observational studies offer limited support to an inverse relationship between phylloquinone intake and risk of cvd, despite high intakes being sometimes regarded as a marker of healthy dietary habits associated with low cardiovascular risk (Reviewed in 77). For example, long courses of antibiotics can kill the gut bacteria that produce vitamin k. Summary: It is best to incorporate a variety of food sources of both vitamin k1 and k2 in your diet to obtain the health benefits that these vitamins offer. Summary you can get vitamin k2 from high-fat dairy products, egg yolk, liver and fermented foods, such as sauerkraut. I see brand life extension super k have vitamin k higher than brand full spectrum vitamin k2 but price cheaper, should my wife take brand life extension? In this case, vitamin k2 impedes the buildup of calcium in the arteries, which can be a side effect of taking a vitamin d3 supplement. I just got the innovix labs vitamin k2 supplement and i am wondering if my wife who has just got pregnant should take this supplement as well as it has a much higher dosage than the recommended. Vitamin k, specifically the vitamin k2 form, plays a significant role in the maintenance of healthy bones, and we are only beginning to appreciate the full extent of it’s impact on human health.

The researchers found that those children and adults with the most pronounced vitamin k2 deficiency showed the highest responses to supplementation with mk-7, children (And adults above the age of 40 years) showed the largest vitamin k2 deficiency, and accordingly may benefit from mk-7 supplementation to improve their vitamin k2 status. Although vitamin k deficiency would seem the most likely cause of elevated blood ucoc/oc ratio, some investigators have documented an inverse relationship between biochemical measures of vitamin d nutritional status and ucoc levels, as well as a significant lowering of ucoc/oc ratio by vitamin d supplementation. The rate of bmd loss at the femoral neck, but not at the lumbar spine, was significantly lower in subjects with supplemental phylloquinone compared to the other two groups. Research suggests that only 10-20% of supplements in solid form are absorbed by the body, while liquid supplements have an absorption rate of up to 95%. Further, potential interaction between vitamin k status and polymorphisms of the vitamin d receptors was investigated. The pharmacology and management of the vitamin k antagonists: The seventh accp conference on antithrombotic and thrombolytic therapy. Research over the past several years shows how valuable and necessary vitamin k is for adults and kids when it comes to supporting cardiovascular, bone, and blood health. A study of the effect of vitamin k upon neonatal survival in african and indian patients.

Thorne Research Vitamin K

Mk-4 supplementation significantly reduced rates of hip fractures, vertebral fractures, and all nonvertebral fractures. However, currently few guidelines recommend vitamin k therapy for prevention or treatment of osteoporosis. It may also help with regulating insulin sensitivity and reducing skin reddening, but more research is needed to determine if vitamin k has an active role to play in these areas. Many experts recommend choosing a supplement that contains magnesium. Taking a vitamin d3 supplement without k2 can have disastrous effect, as vitamin d creates need for vitamin k2 in the body. This review describes the current knowledge on menaquinones, based on the nutrient amount required to prevent deficiency and maintain optimal body stores and/or prevent chronic disease. Mk-7, a long-chain menaquinone, was found to have more beneficial effect on bone and facilitates bone mineralization, including cortical bone structure as compared to mk-4. Animal and human studies suggest that optimal concentrations of both vitamin d and vitamin k are beneficial for bone and cardiovascular health as supported by genetic, molecular, cellular, and human studies. The function of vitamin k 2 in the animal cell is to add a carboxylic acid functional group to a glutamate (Glu) amino acid residue in a protein, to form a gamma-carboxyglutamate (Gla) residue. Furthermore, among those with coronary artery calcification at baseline, phylloquinone treatment reduced calcification progression by 6% compared to the control group.

The vitamin k family appears to be really busy. Between high intakes of vitamin k-2 and a reduced risk of developing peripheral arterial disease (Pad), particularly in people with high blood pressure. 34 Thus, if further trials are performed, vitamin k 1 and k 2 should be tested. Studies on the absorption and metabolism of phylloquinone (Vitamin k1) in man. Within the cell, vitamin k undergoes electron reduction to a reduced form called vitamin k hydroquinone, catalyzed by the enzyme vitamin k epoxide reductase (Vkor). Although both have demonstrated bone health benefits, mk-7, for several reasons, activates the greatest proportion of osteocalcin and is the preferred form for supplementation. To maintain good health, make sure to get adequate amounts of vitamins k1 and k2 through your diet. Structural differences in the different types of vitamin k govern many facts of metabolism of k vitamins including the way they are transported, taken up by target tissues and subsequently excreted. Vitamin k is a group of fat-soluble vitamins that share similar chemical structures. Combining high-potency, natural-source d-3 cholecalciferol with a clinically supported serving size of k-2 menaquinone-7 from fermented chickpea, solaray vitamin d3 and k2 is formulated to help your body transport and absorb calcium, thus helping to support healthy bones and teeth. Vegan favorites like kale, broccoli, soy, and collard greens are all very high in vitamin k. On the bone page, we offer a summary of the research on the bone health benefits of the vitamin k family.

However, that rda, is thought to be insufficient, as it does not include the vitamin k requirements for other bodily tissues. Because osteopenia and osteoporosis affects more than 75 million americans, taking the right bone health supplements, such as vitamin k, can help strengthen your bones and may reduce the risk of your bones becoming brittle, resulting in fractures. I am starting to think i need different couriers to deliver these essential vitamins. Our team feels that these are the best options available right now if you are looking for a vitamin k2 supplement. Finally, use of anticoagulant therapy with vitamin k-antagonists in ckd patients will propel this deficiency even further. The other mk forms are not available in supplement form and can only come from fermented foods and fats of animals that have recently grazed on rapidly growing green grass. Anticonvulsants, if taken during pregnancy or while breastfeeding, can increase the risk of vitamin k deficiency in a fetus or a newborn. Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat. Any thoughts on which supplement i should take between yours and the thorne one? All the vitamin forms and routes detected some level of significance for some of the reported outcomes. Over the years, solaray pioneered many innovative products and became a trusted full-line dietary supplement brand found in health and natural food stores all around the world.

All studies but 1 showed an advantage of phytonadione and menaquinone-4 in terms of bmd. One medic was confused and thought i was taking potassium (K) and i had to educate him on vitamin k2! Effect of food matrix on circulating vitamin k concentrations. Each capsule contains 100 micrograms of vitamin k2, and the capsules are made of vegetarian-friendly glycerine. In this study, all the subjects also received daily, open-label calcium (630 Mg) and vitamin d 3 (400 Iu).

Thorne Research, Vitamin K2, 1 fl oz (30 ml) Product Review

Olive oil. Good. Good. Vit K2. Initial outlay is high, but cost for a low but effective dose is low – the cost/benefit ratio is low to medium (for me). Intestine irritation and fever. Used by the whole family. Highest dose Vit K2 available at the lowest price. Good Remedy for Babies. High quality

It’s the most expensive olive oil you will ever buy.

Very small bottle, but can eat for a long time

I think its a good product, its an expensive outlay, but you are getting plenty of vitamin K2 for your buck. My son says his ankles hurt less when he takes this (he does gymnastics). We are taking it for teeth also, hard to tell for the results on that one, because its a long term thing

I find this product excellent for my problem as it is not in capsule form which I am allergic to; however, I prefer this product with the eye dropper as it used to be as the drops come out much easier,

When I first used this product several years ago, I was taking vitamin D3 on a doctor’s recommendation (blood tests for D were low). I found reports that K2 would help normalize intracellular Calcium (tests were high), so I tried it. However, whenever I would use this product, I experienced a strong correlation with chest pains developing the next day, even when taking a relatively low dose. Eventually, I was experiencing chest pains all the time even without the K2, so I dropped the D3 too, and the pains went away. After a time, I restarted the K2, but not the D3 – no chest pains. My teeth stay cleaner when on K2, and food tastes better though at higher doses (8+ drops/day $$$). I continue taking it in order to reduce intracellular Calcium, but I no longer supplement D3. I prefer the pure K2 over the K2/D3 blend. I have not tried the MK-7 form of K2, but I benefit from the MK-4 form, so am sticking with it. In my experience, Thorne Research products are superior to most others, as is Metabolic Maintenance products. I consider both brands to be standouts for potency and the minimal use of fillers.

Just 2 drops caused intestine irritation and fever. Be very careful with the dose

The effect is good, and complement with D3.

If you’re looking for a cheap high dose Vit K2 then this is it. The dropper is a bit annoying as it’s too slow but at 1 mg/drop it’s quite potent. It’s the only way to get 15 mg/dose (15 drops) on the Foodpharmacy Blog website. Alternatively you can buy tablets but they tend to be expensive and it takes 3x 5 mg tablets to match 15 drops. There are 80x 15 mg doses in a bottle which makes this way cheaper than any other alternative I can find. It’s only a small volume of oil so you barely even taste it as it goes down. That makes it very easy to take. Using this to improve bone density (teeth) and remove calcium from soft tissues. 🙂

Bought specifically to not do in the hospital an injection of vitamin K baby. Excellent replacement prick. In total, 4 drops are needed.

Prefer liquid supplements. Easy to take and absorb. High quality supplement. I have been using for a few years. Highly recommend.

Questions and Answers

Is this synthetic K-2, or natural, which is then concentrated.
The newly changed type of dropping is hard to use. Can it be back to spuit type? The current type is hard to make drops and too slow to drop them!
Can this be given to newborn? As alternative to vitamin k injection at birth? If can be given, how many drops for 3kg newborn?
Does this product still come without dropper? I bought one last year, but when I take one drop, another gets into the cap, causing 50 % go to waste. Also one has to wait long for that drop to come. Not worthy without the dropper.
is there a smaller quantity or smaller than 30ml?
Can liquid vitamin K2 (MK4) from Thorne Research be taken transdermally, by topical administration? If yes, how exactly?
why is this price increasing like every week?
is it vegan?
can I take these drops? when breastfeeding
Hello, please say me if 15 drops contain 15 mg or 15 mcg?

Got this answer from Thorn: The source of the Vitamin K2 is from a natural plant source Geraniol. The mixed tocopherols are from soy but contain no soy residue. Medium chain triglyceride are from palm kernel oil.
I lie down looking up and it takes me a whole minute (60 seconds) or more to wait for all 15 drops haha. I will continue buying though. I’ll try to taking out the cap and use the old dropper.
I bought this for my newborn, so yes, it can be used instead of injection.1 drop (ca.2 mg) At first feed, at 1 week, 4 weeks, 8 weeks
The answer to your question is yes. This product only has the cap and a lid that provides one drop I believe it is 1 mg. However if it provides any conciliation there is about an 8- 10 second wait time before a second drop comes out. There is no dropper, but I find that this format is quite acceptable for my purposes. I hope that this is useful for your decision process.
No.
Some people have told me that you can use this transdermally, the dose you receive will end up being smaller because skin absorption is not as complete. I think it maybe around 20% of whatever you put on. I use Vitamin D3 in MCT oil this way too.
On Foodpharmacy Blog, the price has been stable at $65 in the last few months
Hi, It doesn’t specify if it is vegan but online it says vegan. Don’t quote me
Basically, yes. Supplement companies will always use disclaimers about being pregnant or breastfeeding, unless there’s very specific studies. So we have to rely on critical thinking and the thought process of why you’re taking something, and the quality of the item. If you’re taking this to supplement the K2 we ‘should’ have in food (ie. because animals aren’t raised the same way anymore), which is why you’re likely taking in the first place, and it’s a supplement from a food source anyways (ie. not synthetic), then why not keep using? You would also need to ask if you need those nutrients, and of course your newborn needs some too 🙂 I know that may not be the ‘hard definitive answer’ you want, but that doesn’t exist. Also, the amount of drops this says to take is for some condition I think, I can’t recall what, but I only use 5 drops per day.
15 mg