Product name: Christopher’s Original Formulas, Comfrey Root Extract, 2 fl oz (59 ml)
Quantity: 2 fl oz, 0.14 kg, 3.8 x 3.8 x 11.7 cm
Categories: Christopher’s Original Formulas, Herbs, Homeopathy, Comfrey
The biologically active substances of Dr. Christopher’s Comfrey Root Extract have protective properties lowering blood pressure and stimulating respiratory activity.
Based on clinical signs of poisoning, serum biochemistry, and histopathological analysis the reduced comfrey extract was more toxic than lycopsamine and intermedine. Although case studies are discussed where patients presented with hepatotoxicity due to use of herbal medicines, results from both in vitro and in vivo studies that have been undertaken to confirm liver injury are also included. Male and female aci rats were fed a diet containing comfrey leaves (A) or comfrey roots (B) at different percentages for up to 600 d. Although the mf in the rats fed comfrey at different doses were about fourfold greater than the mf for control rats, there were no significant differences in the mf among the three comfrey-treated groups. Veno-occlusive disease of the liver secondary to ingestion of comfrey. The kitchen itself is a vivid study in sustainable living: There are trays bursting with green sprouting seeds, jars containing rose petals, seaweed, spices, mixed herbal teas, bottles of assorted vinegars, in which quietly marinade flower petals, garlic, assorted herbs, a mix of dandelion, nettles and marigolds. We examined the evidence regarding the effect of herbal medicine on pain in people with non-specific low-back pain (Lbp). Hepatotoxicity induced by herbal and dietary supplements. The entire plantain plant is utilized in homeopathy as the leaves, seeds, stem and tops can all be used for tinctures, oils, salves and more. Although comfrey-induced neoplasms in the rats were found mostly in liver, sporadic urinary papillomas and carcinomas were also observed.
Christopher’s Original Formulas, Comfrey Root Extract, 2 fl oz (59 ml): Comfrey, Homeopathy, Herbs
Since ancient times herbal medicines have been widely used all over the world and have been well recognized by the physicians and patients for their therapeutic value. Gaia herbs vitex berry helps to maintain hormone balanc. Study showed comfrey inhibits nf-kappab signaling at two stages. This compilation of research articles does not necessarily imply that there are adequate results to demonstrate safe and/or effective human use of any herb listed. The objective of this work was to compare the toxicity of a crude, reduced comfrey alkaloid extract to purified lycopsamine and intermedine that are major constituents of s. Comfrey and comfrey-containing pa are both genotoxic and tumorigenic in experimental animals, although the mechanisms are still not fully understood because comfrey contains multiple chemical constituents. I once witnessed the external application of comfrey placed on terrible blue-black colored bruises and after being on the effected area for one night (As a poultice) the bruises quickly started to fade and went from black in color to a pale yellow. Lasiocarpine, a pyrrolizidine alkaloid found in comfrey, undergoes metabolic activation to it’s metabolites including 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5 h-pyrrolizine (Dhp) that reacts with dna, leading to dna adduct formation and liver tumor induction.
However, in many locations comfrey continues to be ingested as a tisane or as a leafy vegetable. Efficacy and tolerance of a comfrey root extract (Extr. Results showed that aqueous extracts of comfrey roots exerted antimitotic effects and induced chromosomal aberrations (Ca). 15 It has been suggested that the efficacy of comfrey is primarily due to it’s anti-inflammatory, analgesic, granulating promoting, and antiexudative properties. Comfrey belongs to the plant family boraginaceae and there are at least five species referred to as comfrey, including symphytum officinale l. Therapeutic use of comfrey is limited because of it’s toxicity. Although not examined in clinical trials, comfrey may possess antifungal and anticancer activity. However, the liver tumor incidence in the rats treated with comfrey roots at 1, 2, 4, and 8% of the diet were 80, 42, 33, and 79%, respectively. As the use of natural medicine increases, the risk of liver toxicity and drug interaction increase as well. The feeding of comfrey roots was more tumorigenic than ingestion of comfrey leaves.
The aim of the present work was to develop and validate an hplc-ms/ms method for the determination of a major pyrrolizidine alkaloid of comfrey (Lycopsamine) in aqueous samples as a basis for the development of a method for the determination of absorption of lycopsamine by human skin. Chinese patent medicine as a potential source of mercury poisoning. Chinese herbal medicines revisited: A hong kong perspective. Our products include herbal tinctures, oils, salves and whole foods, all created from natural, organic or wildcrafted ingredients. Symphytum officinale l (Boraginaceae) species are currently used in the romanian traditional medicine to treat different human and animal disease, being also active in certain cancer forms. The most successful were 10% n-butanolic extract of comfrey, 0,5% chloroform extract of comfrey and 10% n-butanolic extract of yarrow. In addition, both comfrey and riddelliine treatments induced fmo5 about 4-fold and ces2 about 10- and 2-fold, respectively. Enzyme studies showed that calculated v max/k m are low for allantoinase and alantoicase, supporting the results from the feeding experiments, and indicating that accumulation of aln in comfrey is due to a low capacity for the enzymatic degradation of ureides. Humans have widely used comfrey poultices or ointments, and consumed comfrey formulations of tea or tablets. Leaf and root of symphytum species are used by lay public, herbalists and physicians for treatment of broken bones, tendon damage, ulcerations in the gastrointestinal tract, and lung congestion.
Anti-inflammatory activity of patchouli alcohol isolated from pogostemonis herba in animal models. We prepare our comfrey extract from fresh (Undried) roots of symphytum officinale plants which are certified organically grown without the use of chemical fertilizers, pesticides or herbicides 1, and are never fumigated or irradiated. The comfrey roots were ground and then blended with basal diet powder in a hobart mixer. Metabolism of lasiocarpine, which is one of the pa constituents in comfrey, by liver microsomes of male f344 rats was studied by xia et al. Consequently, regulatory agencies and international health organizations have recommended comfrey be used for external use only. According to the same research review, results also suggested that comfrey can help treat osteoarthritis, as well as some injuries, such as ankle sprains. The adverse effects of herbal products must be fully reported as well as extensive education of healthcare providers must be provided in order to reduce danger of alternative medicines. Herbal marijuana alternatives (Hma), legal plant products adulterated with synthetic cannabinoid receptor agonists, represent a growing public health concern. In this study, the phenolic compounds from two plant species used in romanian ethno-medicine were investigated and their antioxi/-dant and cytotoxic activities evaluated.
Christopher’s Original Formulas Comfrey
However, in these studies herbal preparations at pharmacological concentrations were used in humans as well as in animals or in in vitro experiments. In this study, we analyzed mirna and mrna expression in the livers of rats treated with a carcinogenic dose of comfrey (Symphytum officinale) for 12 weeks. I m in physical therapy now and use comfrey ointement by christophers original formulas on my arm daily. If you walk along the somerville bike path you are sure to see some half-wild comfrey growing along the edges. Our data suggest that comfrey may exert it’s carcinogenic effects by disturbing mirna expression resulting in altered mrna levels of the dem-targeted genes that are functionally associated with carcinogenesis. Toxic heavy metals and undeclared drugs in asian herbal medicines. Gaia herbs turmeric supreme sinus support (Formerly turmeric supreme allergy) combines turmeric with other herbal extracts to help you stay feeling healthy during seasonal transitions. The available evidence suggests that the active metabolites of pa in comfrey interact with dna in liver endothelial cells and hepatocytes, resulting in dna damage, mutation induction, and cancer development. Comfrey (Symphytum officinale l), also known as knit bone, has long been advocated in folk medicine for the treatment of wounds, sores, sprains, and bone fractures. Some herbal medicines have been associated with adverse effects and toxic effects, including hepatotoxicity, which have been reversed upon discontinuation of the herbal medicine by the patient.
The interventions were herbal medicines which we defined as plants used for medicinal purposes in any form. School of chinese medicine, the chinese university of hong kong, shatin, n. You may use herbs as dried extracts (Capsules, powders, or teas), glycerites (Glycerine extracts), or tinctures (Alcohol extracts). The irony of herbal hepatitis: Ma-huang-induced hepatotoxicity associated with compound heterozygosity for hereditary hemochromatosis. Systematic reviews focussing on particular indications may clarify the treatment effect and safety of external comfrey preparations. The search for wound healing agents is one of the oldest challenges in medicine, as the mechanism involved in the repair of damaged tissue is yet not fully understood. Comparative studies showed that comfrey and riddelliine (A prototypical pa) induced similar profiles of dhp-derived dna adducts as well as similar mutation spectrum profiles in the liver. The most common name of comfrey, knitbone, derives from it’s ability to improve sprains, burning and bruising when used externally. Hepatic veno-occlusive disease associated with comfrey ingestion.
Moxibustion for asthma, acupuncture for epilepsy, psychological therapies for irritable bowel syndrome, exercise training for multiple sclerosis, and comfrey root for acute back pain. For the past eight years she has served at bastyr as department chair of botanical medicine, teaching and administering to both the naturopathic program and the bachelor of science in herbal sciences program. The pyrrolizidine alkaloids present a serious health risk to human populations that may be exposed to them through contamination of foodstuffs or when plants containing them are consumed as medicinal herbs. Linking to herbal constituents the spectrum of liver toxicity includes elevated liver enzymes, acute or chronic hepatitis, cholestasis, hepatic necrosis, fibrosis, and cirrhosis, as well as acute liver failure and hepatic veno-occlusive disease. Clinical and analytical aspects of pyrrolizidine poisoning caused by south african traditional medicines. For drug-herb interactions and examine potentially beneficial herbal therapies. (Common comfrey; the major comfrey species), s. Comfrey is one of my favorite herbs for bruises, especially, and i have seen it work it’s magic overnight. To our knowledge, the combination of comfrey and ta in the treatment of oa is unique and has yet to be investigated.
Com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Among the comfrey-regulated drug metabolizing genes, 22 genes were also altered by riddelliine treatment in the livers of exposed rats, with changes in the same direction (Table 2). Titanium micro-implants were placed in the tibia of rats and animals received drinking water with or without 10 drops of comfrey per day for 7, 14, or 28 d. Comfrey is also consumed as a vegetable and is one of the most popular herbal teas in many countries. Ingredients: Certified organic cane alcohol (52-62%), Distilled water and certified organic comfrey extractives.