Limited evidence from preliminary trials suggested that i3c supplementation may help treat conditions related to human papilloma virus (Hpv) infection, such as cervical/vulvar intraepithelial neoplasias and recurrent respiratory papillomatosis. This proven antioxidant team includes quercetin, turmeric extract and citrus bioflavonoids. Animal studies have suggested that alfalfa sprouts may have antioxidant effects and may reduce inflammation. The potential for i3c supplementation to shift endogenous estrogen metabolism toward the less estrogenic metabolite 2he 1, and away from the highly estrogenic metabolite 16he 1 (See anti-estrogenic activities), led to interest in it’s use in sle. There are no unnecessary fillers or additives in thorne supplements. Brown sea vegetables, such as kelp and wakame, contain another potent antioxidant called fucoxanthin. Although oral supplementation of i3c or dim appears relatively safe and well tolerated, results obtained with i3c are only preliminary, and interventions with dim failed to show preventative or therapeutic efficacy in women with precancerous lesions of the cervix.
The potential for i3c supplementation to shift endogenous estrogen metabolism toward the less estrogenic metabolite 2he 1, and away from the highly estrogenic metabolite 16he 1 (See anti-estrogenic activities), led to interest in it’s use in sle. As a nutritional supplement, i3c provides key nutritional support for the liver’s detoxification of estrogens, thus playing an important role in supporting female reproductive health. Now indole-3-carbinol (I3c) provides powerful antioxidant support. In some animal models, i3c supplementation was found to enhance carcinogen-induced cancer development when given chronically after the carcinogen (96-99). A supplemental dose of approximately 100mg dim has been noted to alter urinary estrogens in a manner thought to reflect less estrogenicity. In addition, studies have shown that i3c supplementation can help maintain a healthy endocrine response in both men and women. Although the long-term effects of i3c supplementation on cancer risk in humans are not known, the contradictory results of animal studies have led several experts to caution against the widespread use of i3c and dim supplements in humans until their potential risks and benefit…
Ingredients: Now foods – i3c indole 3 carbinol with lignans – 60 vegetarian capsules supplement facts serving size: 1 Vegetarian capsules servings per container: 60 Amount per serving %dv indole-3-carbinol (I3c) 200 mg linumlife? It is the nastiest smelling and tasting supplement i have ever come across. The total phenolic contents, the scavenging activities against dpph, oxygen, hydroxyl and abts cation radicals, and cell-based antioxidant activities were determined for the antioxidant capacities. Foodpharmacy Blog and it’s editors do not ensure that unforeseen side effects will not occur even at the proper dosages, and thereby does not assume liability for any side effects from supplements or practices hosted under the domain of examine. Some experts have cautioned against the widespread use of i3c and dim supplements for cancer prevention in humans until their potential risks and benefits are better understood. Sulforaphane and it’s sulfide and sulfone analogues induced both quinone reductase and glutathione transferase activities in several mouse tissues. Mangosteen contains antioxidants known as xanthones, compounds found to have strong antioxidant properties. The nuclear factor-eryt…
These all enhance the overall antioxidant power of the powder. There are no unnecessary fillers or additives in thorne supplements. In another six-month randomized, double-blind controlled trial, dim supplementation (150 Mg/day) failed to promote hpv clearance and prevent cin progression in 551 women with low-grade cell abnormalities in cervical smears. Such conflicting data indicate that clinical trials are required to establish the in vivo effects of such an intervention when using a clinically relevant dose of a readily available supplement. However, the beneficial properties of isothiocyanates stimulated an increase of dietary supplements and functional foods with highly enriched isothiocyanate concentrations on the market. The nuclear factor-erythroid-2-related factor 2 system, which orchestrates the expression of a wide array of antioxidant genes, plays a role in the protective effect of isothiocyanates against almost all the pathological conditions reported above. It provides powerful antioxidant protection, working to prevent cellular damage caused by free radicals.