Product name: Thorne Research, Indole-3-Carbinol, 60 Capsules
Quantity: 60 Count, 0.05 kg, 9.7 x 5.1 x 5.1 cm
Categories: Thorne Research, Supplements, Antioxidants, Indole 3 Carbinol, Gluten Free
Dietary Supplement, Liver/Detox, Women’s Health, Gluten Free.
These all enhance the overall antioxidant power of the powder. There are no unnecessary fillers or additives in thorne supplements. In another six-month randomized, double-blind controlled trial, dim supplementation (150 Mg/day) failed to promote hpv clearance and prevent cin progression in 551 women with low-grade cell abnormalities in cervical smears. Such conflicting data indicate that clinical trials are required to establish the in vivo effects of such an intervention when using a clinically relevant dose of a readily available supplement. However, the beneficial properties of isothiocyanates stimulated an increase of dietary supplements and functional foods with highly enriched isothiocyanate concentrations on the market. The nuclear factor-erythroid-2-related factor 2 system, which orchestrates the expression of a wide array of antioxidant genes, plays a role in the protective effect of isothiocyanates against almost all the pathological conditions reported above. It provides powerful antioxidant protection, working to prevent cellular damage caused by free radicals.
Thorne Research, Indole-3-Carbinol, 60 Capsules: Indole 3 Carbinol, Antioxidants, Supplements
Although oral supplementation of i3c or dim appears relatively safe and well tolerated, results obtained with i3c are only preliminary, and interventions with dim failed to show preventative or therapeutic efficacy in women with precancerous lesions of the cervix. Foodpharmacy Blog and it’s editors do not ensure that unforeseen side effects will not occur even at the proper dosages, and thereby does not assume liability for any side effects from supplements or practices hosted under the domain of examine. A small randomized trial in 12 women with vin found that supplementation with 200 mg/day or 400 mg/day of i3c for six months improved overall symptoms, as well as lesion size and appearance. Some experts have cautioned against the widespread use of i3c and dim supplements for cancer prevention in humans until their potential risks and benefits are better understood. The information on dietary factors and supplements, food, and beverages contained on this website does not cover all possible uses, actions, precautions, side effects, and interactions. I3c has recently become available as a nutritional supplement and it provides an attractive natural product for drug development in the pharmaceutical industry. Dietary desmutagens may function as chemical inactivaters, enzymatic inducers, scavengers, or antioxidants. Dim is available without a prescription as a dietary supplement, alone or in combination products. Although supplementation with i3c and dim could alter urinary estrogen metabolite profiles in women, the effects of i3c and dim on breast cancer risk are not known.
It’s high antioxidant value makes it an excellent choice for achieving and maintaining total-body wellness. Use auto ship and earn to save time and money and never be without the vitamins, supplements or other health products that are part of your daily routine. In some animal models, i3c supplementation was found to enhance carcinogen-induced cancer development when given chronically after the carcinogen (96-99). However, preliminary evidence that i3c and dim can increase the activity of cyp1a2 (111, 112) Suggests the potential for i3c or dim supplementation to decrease serum concentrations of medications metabolized by cyp1a2. This proven antioxidant team includes quercetin, turmeric extract and citrus bioflavonoids. Search for: Interaction with medications, supplements. Limited evidence from preliminary trials suggested that i3c supplementation may help treat conditions related to human papilloma virus (Hpv) infection, such as cervical/vulvar intraepithelial neoplasias and recurrent respiratory papillomatosis. Studies have shown that i3c supplementation can help maintain the health of the breast and other reproductive organs. Eating right, sleeping enough, reducing stress and supporting your body with the right supplements will go a long way toward bringing you back to health. Both it’s high bioavailability and significant nrf2 inducer capacity contribute to the therapeutic potential of sulforaphane-yielding supplements.
The study also showed that selenium supplementation improved metabolic markers of insulin sensitivity, which may be associated with improved immune system function. Our nutritional supplements and wellness products are trusted by healthcare practitioners and consumers worldwide. Research suggests that fucoxanthin has 13,5 times the antioxidant power of vitamin e. None of these indoles caused an elevation in either aldo-keto reductase 1c1 (Akr1c1) or the gamma-glutamylcysteine synthetase heavy subunit (Gcs(H)), but dim, i3c, and icz produced a very modest increase in nad(P)h:Quinone oxidoreductase 1 (Nqo1). According to researchers, estrogen quinones are now recognized as a significant mechanism of estrogen-mediated cell damage. By virtue of it’s lipophilic nature and low molecular weight, sulforaphane displays significantly higher bioavailability than the polyphenol-based dietary supplements that also activate nrf2, nrf2 activation induces cytoprotective genes such as those playing key roles in cellular defense mechanisms including redox status and detoxification. A small placebo-controlled trial in women examined the effect of oral i3c supplementation on the progression of precancerous cervical lesions classified as cervical intraepithelial neoplasia (Cin) 2 or cin 3. So while this could have very likely happened on it’s own with no work on my part, i wanted to share the supplements i took just in case they helped a little.
Evidence is presented that the ability of indoles and isothiocyanates to stimulate either xenobiotic response element- or antioxidant response element-driven gene expression accounts for the two groups of phytochemicals inducing different gene batteries. In a small clinical trial, dim supplementation at a dose of 108 mg/day for 30 days increased urinary 2he 1 excretion in postmenopausal women with a history of breast cancer. The sgs broccoli seed extract used in hormone protect is a super vegetable that delivers extended antioxidant support and boasts a very high level of glucoraphanin (13%). His research into the benefits of vitamins and supplements nurtured a deep commitment to wellness at every age and a desire to share his findings with others. Now indole-3-carbinol (I3c) provides powerful antioxidant support. Research suggests that when sgs is broken down to sulforaphane (Its active form), it safely and effectively upregulates the nrf2 system, activates the antioxidant response element (Are), enhances the production of important antioxidants, and activates vital phase ii detoxification enzymes. Now i3c provides powerful antioxidant protection helping to prevent cellular damage caused by free radicals.
Thorne Research Indole 3 Carbinol
It’s a powerful antioxidant and may protect cells and dna against chemical damage. Estrodim is a targeted supplement that combines the synergistic benefits of the cruciferous vegetable metabolites i3c and dim to support proper estrogen metabolism. Beets contain an antioxidant called alpha-lipoic acid, which might be helpful for diabetes-related nerve problems, called diabetic neuropathy. For instance, goji berries are a rich source of antioxidants. It is the nastiest smelling and tasting supplement i have ever come across. Due to a lack of scientific support, it’s too soon to recommend diindolylmethane supplements as a standard treatment for any health condition. As a nutritional supplement, i3c provides key nutritional support for the liver’s detoxification of estrogens, thus playing an important role in supporting female reproductive health.
Tomatoes contain lycopene, which is a powerful antioxidant that may play a role in cancer prevention. However, randomized controlled trials are needed to determine whether i3c supplementation is beneficial. In addition, studies have shown that i3c supplementation can help maintain a healthy endocrine response in both men and women. Brown sea vegetables, such as kelp and wakame, contain another potent antioxidant called fucoxanthin. There have been several studies conducted to support the potential benefits of vitamins and natural supplements in clearing hpv infection and healing precancerous changes of the cervix. Quinone reductase enzymatic activity, a surrogate of global phase 2 enzyme activity, was assayed by the menadione-coupled reduction of tetrazolium dye. This study evaluated the effects of grinding and chopping with/without microwaving on the health-beneficial components, and antioxidant, anti-inflammation and anti-proliferation capacities of commercial kale and broccoli samples. The supplement itself has helped tremendously. Resveratrol is one of the most powerful antioxidants known to science. A small uncontrolled trial of i3c supplementation (375 Mg/day) in female sle patients found that i3c supplementation increased urinary 2he 1:16He 1 ratios, but the trial found no significant change in sle symptoms after three months. Potential mechanisms of estrogen quinone carcinogenesis. Vitamin c acts as an important antioxidant in the brain and may assist in the prevention of cognitive decline as we age.
Although eating more cruciferous vegetables would be ideal, the cooking process decreases the amount of i3c available for absorption in the body, thus supplementation can help reach nutritional needs. The safety of i3c or dim supplements during pregnancy or lactation has not been established. Slight increases in the serum concentrations of the liver enzyme, alanine aminotransferase (Alt) were observed in two women who took unspecified doses of i3c supplements for four weeks. Each woman took a placebo capsule or an i3c capsule daily for a total of 4 weeks; none of the women experienced any significant toxicity effects. We proudly offer you our ever-growing selection of vitamin and supplement products designed to help you achieve your wellness goals at the lowest cost in the industry! If using any pharmaceuticals or drugs given to you by a doctor or received with a prescription, you must consult with the doctor in question or an equally qualified health care professional prior to using any nutritional supplementation. As a dimer (Formed chemical structure of two substances) of indole-3-carbinol, dim promotes beneficial estrogen metabolism in both sexes supporting the formation of healthy estrogen metabolites and enhances the potential for greater antioxidant activity.
The urinary estrogen ratio (A biomarker inversely related to breast cancer development) did not significantly change after supplementation. Foodpharmacy Blog does not assume liability for any actions undertaken after visiting these pages, and does not assume liability if one misuses supplements. A supplemental dose of approximately 100mg dim has been noted to alter urinary estrogens in a manner thought to reflect less estrogenicity. We believe in health and vitality at every age, which is why our nutrition scientists and innovation experts continually search the globe for better ingredients and new scientific research findings to create vitamins, supplements and wellness products that fit easily into your modern life. Nearly 50 years later, we continue to innovate science-backed vitamins and supplements, delivering wellness solutions that help people live simply healthier together, and find vitality at any age. In addition, some animal studies indicate that i3c supplementation might have tumor-promoting effects. Probiotics are beneficial bacteria that are present in the body and in some foods and supplements.
Always consult with a qualified healthcare professional prior to beginning any diet or exercise program or taking any dietary supplement. Other potent antioxidants in tomatoes, such as lutein and zeaxanthin, may protect vision. The potential for i3c supplementation to shift endogenous estrogen metabolism toward the less estrogenic metabolite 2he 1, and away from the highly estrogenic metabolite 16he 1 (See anti-estrogenic activities), led to interest in it’s use in sle. Consume immune boosting foods with plenty of vitamins and antioxidants known for their ability to fight off viruses. Mangosteen contains antioxidants known as xanthones, compounds found to have strong antioxidant properties. Sulforaphane and it’s sulfide and sulfone analogues induced both quinone reductase and glutathione transferase activities in several mouse tissues.