Sundown Naturals, Standardized Milk Thistle, 240 mg, 60 Capsules

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Product name: Sundown Naturals, Standardized Milk Thistle, 240 mg, 60 Capsules
Quantity: 60 Count, 0.04 kg, 9.9 x 5.1 x 5.3 cm
Categories: Sundown Naturals, Herbs, Homeopathy, Milk Thistle Silymarin, Dairy Free, Casein Free, No Artificial Flavors, Non Gmo, Certified Gluten Free, Gluten Free, No Artificial Colors, No Preservatives

Supports Healthy Liver Function, Herbal Supplement, 100% Free of: No Dairy/Lactose, No Artificial Flavors, Non-GMO, Certified Gluten-Free, Smart Facts, No Artificial Colors, No Preservatives, Contains Dandelion, Fennel and Licorice.

The impact of silymarin and it’s components on signaling pathways has been investigated in several studies. Wish i could read more comments where milk thistle made a significant difference in a dog already jaundiced and not wanting to eat much. This article explores 10 potential milk thistle benefits and examines whether there is any scientific evidence to support it’s use. More research is needed to see if silymarin benefits asthma symptoms in humans. Pregnant or breastfeeding women should not use milk thistle or licorice. The published data on silymarin use in children focuses on intravenous doses of 20 to 50 mg/kg of body weight for mushroom poisoning. Additionally, varicocelized rats receiving silymarin had higher testosterone levels and a larger percentage of sperm with nuclear maturity compared with varicocelized rats not receiving treatment. They were randomly divided into four groups, with the silymarin patients receiving 800 mg a day for 90 days. In traditional chinese medicine, milk thistle is referred to as da ji, while the seeds are called shui fei ji. Though studies in the lab have shown that milk thistle may protect and promote the growth of liver cells, clinical trials have been mixed at best, and many of the studies have not been well designed.

Sundown Naturals, Standardized Milk Thistle, 240 mg, 60 Capsules: Milk Thistle Silymarin, Homeopathy, Herbs

On the other hand, there exists a lack of regulators to oversee the use of natural medicine. The active ingredient in milk thistle, silymarin, acts as an antioxidant by reducing free radical production. In homeopathic medicine, a tincture of the seeds has been used to treat liver disorders, jaundice, gallstones, peritonitis, hemorrhage, bronchitis, and varicose veins. A few trials have looked at milk thistle for people with cancer. The achene contains 1,5-3% silymarin, a mixture of flavonolignans including silybin (Also known as silibinin, about 50%), and lesser amounts of dehydrosilybin, silychristin, silydianin, and isosilybin (A stereoisomer of silybin), plus some polymeric products of silybin known as silybinomers, primarily consisting of the trimer, tetramer and pentamer. Treatment of chronic liver diseases with traditional chinese medicine. Analysis of characteristics of traditional chinese medicine and western medicine clinical use in patients with viral hepatitis based on real world hospital information system data. They suggest that a substance in milk thistle (Silymarin) can protect the liver from damage caused by viruses, toxins, alcohol, and certain drugs such as acetaminophen (Tylenol). The use of a medicinal herb, alone or in combination with other herbs, can be thought of as a type of combination therapy because of the complexity of the phytochemicals and bioactivities in the plant. Zi x, agarwal r: Modulation of mitogen-activated protein kinase activation and cell cycle regulators by the potent skin cancer preventive agent silymarin.

I always combine our trips with a stop at vitamin world to pick up a supply of milk thistle. Both silibinin and silymarin exerted activity against candida albicans, candida tropicalis, and candida krusei. A case report from australia described a reaction to a milk thistle extract that included intermittent episodes of sweating, abdominal cramping, nausea, vomiting, diarrhea, and weakness. By clearing undigested, built up matter from the colon, an ultimate herbal detox program with a high dose of herbs will reduce the amount of re-circulating waste substances straining the liver. Pregnant and breastfeeding women should never take herbs or supplements unless expressly approved by their physicians. Agents used in naturopathy must exist in nature, with no chemical additives, and have undergone no or very little processing, such as herbs, nutrients, diet supplements, etc. According to the german commission e, there are no reported side effects with milk thistle when the recommended doses are used. Some forms of hepatitis have responded to silymarin treatment.

We use a triple percolation process which creates, without heat, a more concentrated extract which contains the full-spectrum of milk thistle’s silymarin flavonoids silybin, silydianin and amp; silychristin. If you have cirrhosis, your doctor will use caution when prescribing medications because many medicines cause complications in people with liver disease. Added text to state that the impact of silymarin and it’s components on signaling pathways have been investigated in several studies; in in vitro and in vivo studies utilizing the sk-mel-5 melanoma cell line, silybin significantly inhibited growth through it’s direct binding with mek1/2 and ribosomal s6 kinase-2, resulting in the inhibition of catalytic kinase activities (Cited lee et al. Patients were randomly assigned to receive 420 mg of silymarin, 700 mg of silymarin, or a matching placebo orally 3 times per day for 24 weeks, with the aim of reducing alt levels to less than 40 u/l or less than 65 u/l if this was at least a 50% decline from the baseline level. The botanical name for milk thistle is silybum marianum (L). However, when silymarin was combined with these agents, serum indices and hepatic markers were reduced. Studies have found that silymarin reduces transcription of markers of tumor promotion and activity, inhibits transcription of tumor promoters, interferes with cell signaling, inhibits inflammatory actions, and modulates cell-cycle regulation. We performed a systematic review of the literature to determine the efficacy and safety of this herb for the treatment of liver disease.

Although herbal medicine systems are sometimes misinterpreted as being unscientific and anachronistic, their long-term existence proves they are able to compete with western drugs at some level. Ultimate herbal health products comply with the dietary supplement laws in new zealand. Chinese herbal medicine and interferon in the treatment of chronic hepatitis b: A meta-analysis of randomized, controlled trials. Active compounds and biological actions of antidiabetic herbs. On rare occasion, milk thistle can cause a potentially life-threatening, all-body allergy known as anaphylaxis. Glucose (Re)absorption is viewed as an alternative way to lower blood glucose level. Summary the active ingredients in milk thistle have been shown in animals to improve the effects of some cancer treatments. About a third of people battling hepatitis c infection say they have tried milk thistle capsules, extracts or powders, a figure that helps explain the roughly $100 million in annual sales of the products. Several studies have suggested that milk thistle may be beneficial for people with diabetes, most notably in those with type 2 diabetes. The content of silymarin is calculated as silybin.

Sundown Naturals Milk Thistle Silymarin

A number of laboratory studies have investigated the effect of silymarin or silybin on the efficacy and toxicity of chemotherapy agents or have measured their direct cytotoxic activity. The active constituents of this herb such as flavonoids and caffeoylquinic acid may be responsible for this effect. Collectively, these findings suggest that mate and probably it’s active compounds act as an antidiabetic medicine through augmentation of glp-1 production. For these reasons, you should take herbs with extreme care, and only under the supervision of your doctor. Silymarin gel (1%) Containing 80% active ingredient based on silymarin flavonolignans was applied twice daily to the soles and palms for the 9-week chemotherapy cycle. Although more research is needed on how it works, milk thistle is thought to reduce damage to the liver caused by free radicals, which are produced when your liver metabolizes toxic substances. The active ingredient in milk thistle can help to reduce inflammation. Research in the laboratory has shown that milk thistle might help to treat some liver diseases, such as hepatitis and cirrhosis. Although milk thistle has not significantly altered the course of chronic liver disease, it has reduced liver enzyme levels and demonstrated anti-inflammatory and t cell-modulating effects. Oral consumption of milk thistle (Standardized to 70% to 80% silymarin) at 420 mg/day is considered safe for up to 41 months based on clinical trial data.

Do not harvest milk thistle plants that have been exposed to pesticides or found along roadways or industrial sites. Antiviral agents from plants and herbs: A systematic review. The effect of silymarin on capecitabine-induced hand-foot syndrome was evaluated in 40 patients with gi cancer in a double-blind, randomized, placebo-controlled trial. Toxic effects of silymarin have not been noted clinically at a dosage of 1,200 mg/day; however, mild allergies were reported with dosages greater than 1,500 mg/day. In another randomized, placebo-controlled study of patients with viral hepatitis b, silymarin (210 Mg/d) had no effect on course of disease or enzyme levels. In an investigation of the effect of a variety of flavonoids on the formation of dna damage, silymarin did not induce dna damage in colon (Caco-2) cells, hepatoma (Hepg2) cells, and human lymphocytes. Sixty women in the psychiatric ward of an italian hospital were selected for the trial, all having been treated with either phenothiazines and/or butyrophenones for at least five years.

In ovariectomized rats, treatment for 12 weeks with silymarin prevented bone loss, either through increasing formation via an effect on calcium, phosphorus, osteocalcin, and parathyroid hormone, or through direct action with estrogen receptor-beta. Milk thistle is one of very few traditionally used herbs that has been widely accepted by conventional science to have significant medicinal value. Sylvestre is an indian medicinal herb that has been used to treat diabetes for centuries. However, studies on the milk thistle’s effectiveness in treating liver disorders have yielded mixed results. The aim of this review study was to investigate the view of iranian traditional medicine on this plant and it’s comparative analysis with new studies. The pdq integrative, alternative, and complementary therapies editorial board uses a formal evidence ranking system in developing it’s level-of-evidence designations. It’s seeds are used as a chinese herbal medicine for pain, gastrointestinal diseases, and others. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as silybum marianum. She recalled taking milk thistle for headaches and liver cleansing for about 2 months. A number of studies have investigated the mechanism through which silymarin may affect tumor promotion in mouse skin tumor models. When reported, side effects for milk thistle are generally gut disturbances like diarrhea, nausea or bloating. The aim was to see if the silymarin gel could help prevent radiodermatitis (Sore, inflammed skin caused by radiotherapy).

Until more research is carried out, however, milk thistle is not recommended as the primary treatment option for liver problems. A level of evidence score cannot be assigned to milk thistle because there has been insufficient clinical research to date. The seed-like fruits (Achenes) of milk thistle are the medicinal parts of the plant. In a study of rats receiving ethanol during specific weeks of the gestational period, coadministration of silymarin with ethanol resulted in no deficits in spatial working memory in rats on postnatal day 60, suggesting silymarin provided a protective effect against alcohol-induced learning issues. In a double-blind, placebo-controlled trial, 50 children who were undergoing treatment for acute lymphoblastic leukemia, and who had chemotherapy-related hepatotoxicity, were randomly assigned to receive silymarin or placebo for a 4-week period.