Product name: VegLife, Supreme Vegan D, 2000 I.U, 100 Tablets
Quantity: 100 Count, 0.09 kg, 5.1 x 5.1 x 10.2 cm
Categories: VegLife, Supplements, Vitamins, Vitamin D, D2 Ergocalciferol, Vegan, Certified Vegan, Vegetarian
Lanolin-Free, High Potency, 100% Vegan, Synergistic Herbal Base, Certified Vegan, Dietary Supplement, Vitamin D provides nutritive support of skeletal growth and strong bones and is intended to work synergistically with calcium and phosphorus for enhanced absorption.
Matsuoka ly, ide l, wortsman j, maclaughlin j, holick mf: Sunscreens suppress cutaneous vitamin d3 synthesis. Strategies to increase the amount of vitamin d in newborns using high dosage maternal supplementation show potential in preventing vitamin d deficiency in newborn infants (64-66), But are not part of public health policy recommendations at this time. There is evidence of efficacy for it’s therapeutic use in several medical conditions, as well as of the dangers associated with vitamin d insufficiency or deficiency. Gastrointestinal effects and renal calculi continue to be mentioned as statistically more likely in vitamin d treatment groups than placebo groups. Vitamin d can be measured with a blood test for 25-hydroxyvitamin d. These five systematic reviews were: 1) The international agency for research on cancer report on vitamin d and cancer That searched randomized trials on vitamin d supplements for a multiplicity of outcomes, including nonskeletal or postural endpoints; 2) the cochrane review on prevention of postmenopausal fractures ; 3) A review on the prevention of fracture and falls commissioned by the u. This results in malabsorption of fat-soluble vitamins, including vitamin d. Does vitamin d supplementation alleviate chronic nonspecific musculoskeletal pain? Given that both ergocalciferol and cholecalciferol undergo metabolic changes in the human body, which differ from other animals, it should make sense that a binding study in rats may not be sufficient to show equivalence.
VegLife, Supreme Vegan D, 2000 I.U, 100 Tablets: D2 Ergocalciferol, Vitamin D, Vitamins, Supplements
Adams js, clemens tl, parrish ja, holick mf: Vitamin-d synthesis and metabolism after ultraviolet irradiation of normal and vitamin-d-deficient subjects. None of the major cardiology societies have made recommendations for the optimum supplementation for cardiovascular disease. There have been dozens of clinical trials testing the effects of supplementation of vitamin d, often with calcium, on various medical conditions. Wortsman j, matsuoka ly, chen tc, lu z, holick mf: Decreased bioavailability of vitamin d in obesity. We did not address effects of supplementation in non-caucasian subjects or in patients with chronic conditions, and specific meta-analyses should be done in these groups. Some preliminary studies link low vitamin d levels with disease later in life. The induction of the catabolism of 1,25-dihydroxyvitamin d by these drugs is thought to contribute to their deleterious side effects. This level is often considered as reflecting long-term individual vitamin d status. According to some studies, vitamin d3, which is produced by the skin, is more powerful, hence more effective at raising blood levels compared with vitamin d2, however, some studies say they are equal. Leventis p, patel s: Clinical aspects of vitamin d in the management of rheumatoid arthritis.
There is a paucity of cause-and-effect data surrounding vitamin d supplementation, but an abundance of associative data regarding low vitamin d levels. The conversion of calcifediol to calcitriol is catalyzed by the enzyme 25-hydroxyvitamin d 3 1-alpha-hydroxylase, which is the product of the cyp27b1 human gene. Vitamin d supplementation of canadian infants: Practices of montreal mothers. Although this strategy can be a useful methodology to force a physiologic change (And, thus, to possibly piece together a mechanism of action), these studies offered little information for lower doses, which are more realistic in terms of what individuals are likely to be able to consume within their daily diet and gain from sunlight exposure and the concentrations of ergocalciferol and cholecalciferol available in commercial supplements. In contrast, holick et al Recently demonstrated that vitamin d 2 and vitamin d 3 were equally efficacious in raising 25-ohd concentrations when given as a daily 1,000-iu dose. Scientific opinion on the tolerable upper intake level of vitamin d. Conclusions: This meta-analysis indicates that vitamin d 3 is more efficacious at raising serum 25(Oh)d concentrations than is vitamin d 2, and thus vitamin d 3 could potentially become the preferred choice for supplementation. The interventions used for all studies were vitamins d 2 and d 3 of varying dosages and treatment time periods.
Although there are differences of opinion regarding the 25(Oh)d levels that define vitamin d insufficiency and deficiency, most experts agree that levels lower than 20 ng/ml (50 Nmol/l) are suboptimal for skeletal health. Inverse associations were found between increases in 25-hydroxyvitamin d levels and the baseline serum 25-hydroxyvitamin d levels or the concomitant intake of calcium supplements, but these associations were not statistically significant. For addressing the dose-response issue and for ascertaining the clinical significance of changes in 25-hydroxyvitamin d level obtained in the whi trial, we made a systematic review of changes in circulating 25-hydroxyvitamin d level reported by randomized trials that tested supplementation with vitamin d in mainly caucasian subjects over 50 yr old. A fourth source of variability was probably the different laboratory tests used for measuring serum 25-hydroxyvitamin d concentrations. Recommended daily vitamin d supplementation for adults. Vitamin d deficiency can result in lower bone mineral density and an increased risk of reduced bone density (Osteoporosis) or bone fracture because a lack of vitamin d alters mineral metabolism in the body. This complication in the hydroxylation and deactivation processes of ergocalciferol and cholecalciferol that could impact efficacy is explored to some degree in a small number of the clinical trials included in this review.
Low levels of vitamin d are associated with two major forms of human inflammatory bowel disease (Ibd): Crohn’s disease and ulcerative colitis. Stability of vitamin d in foodstuffs during cooking. Prevention of rickets and vitamin d deficiency in infants, children, and adolescents. To maintain adequate vitamin d levels, make sure to regularly eat plenty of foods rich in vitamin d or spend some time in the sun. The intervention was oral or i am supplements of vitamin d2 (Ergocalciferol) or d3 (Cholecalciferol), with or without concomitant calcium supplement. 1 For people suffering from malabsorption syndromes, 50,000 iu d2 is used orally daily to weekly, or adequate sun exposure; tanning beds have also been explored for use in this context; 1,6 it is possible that people who are obese also need higher vitamin d dosing. Some ready-to-eat cereals for breakfast often contain small amounts of added vitamin d, as do some brands of orange juice and yogurt. In argentinean children, a single 150,000-iu oral dose of ergocalciferol safely maintained 25-ohd levels at a mean of 18,7 ng/ml but did not improve serum pth concentrations. Low vitamin d associated with worse angiographic cad, nonarterial stiffness, or pvd. Of note, most dosing is in terms of international units, or iu (1 Iu is the equivalent of 25 ng of vitamin d). Intestinal calcium absorption: Molecular vitamin d mediated mechanisms. worst-best case And best-worst case Scenario analyses demonstrated that vitamin d could be associated with a dramatic increase or decrease in mortality.
VegLife D2 Ergocalciferol
Effects of vitamin d supplementation during pregnancy on neonatal vitamin d and calcium concentrations: A systematic review and meta-analysis. No international standard has been established for vitamin d sufficiency, and some studies suggest 30 ng/ml should be the minimal level for sufficiency (18, 19). In fact, studies suggest vitamin d2 is more sensitive to humidity and fluctuations in temperature. While symptoms are more or less non-existent, the result of a vitamin d deficiency can be more serious. The concentrations of vitamin d precursors produced in the skin reach an equilibrium, and any further vitamin d produced is degraded. By binding to vitamin d-binding protein, calcitriol is transported throughout the body, including to the classical target organs of intestine, kidney and bone. Vitamin d supplementation and body weight status: A systematic review and meta-analysis of randomized controlled trials. Bischoff-ferrari ha, willett wc, wong jb, giovannucci e, dietrich t, dawson-hughes b: Fracture prevention with vitamin d supplementation: A meta-analysis of randomized controlled trials. The results of observational studies could be the consequence of confounding factors, whereas the whi trial findings would indicate a genuine absence of effect of vitamin d status on colorectal cancer risk.
Primitive vertebrates in the ocean could absorb calcium from the ocean into their skeletons and eat plankton rich in vitamin d. Although you need both forms, vitamin d3 is more important for your health and wellbeing. The limitations of this review are based largely on the inconsistencies between study populations and vitamin doses, which prevent reliable inter-study comparisons, in addition to the lack of data from healthy, nonelderly, adult populations, which would allow the impact of vitamin d supplementation to be observed without concurrent disease processes. The uncertain significance of low vitamin d levels in african descent populations: A review of the bone and cardiometabolic literature. Practices of vitamin d recommendation in las vegas, nevada. They considered that average requirements and population reference intakes values for vitamin d cannot be derived, and that a serum 25(Oh)d concentration of 50 nmol/l was a suitable target value. They were also critical of beneficial claims linked to taking supplements, saying there were no health guarantees other than for healthy bones (When taken with calcium). Until now studies evaluating the effect of vitamin d on the body’s immunity to mycobacteria, the family of bacteria that cause tb, are scanty.
Led by beatriz oliveri, the researchers recruited 33 healthy people with an average age of 33 and divided them into three groups: One group was placebo, and the other two received a starting dose of 100,000 iu of either vitamin d2 or d3, one week later they were then given 4,800 iu per day of the same d form for a further two weeks. However, according to the model derived from the meta-regression, the increase obtained by the whi trial was about half the expected average increase based on randomized trials that reported the influence of vitamin d3 supplements on serum 25-hydroxyvitamin d concentration. E, those with low basal serum 25(Oh)d show the greatest response to supplementation. Armas et al Chose a single bolus of 50,000 iu that again showed a significantly greater auc for cholecalciferol than for ergocalciferol, with serum 25(Oh)d 2 concentrations that fell rapidly back to baseline after only 14 d, whereas serum 25(Oh)d 3 concentrations peaked at the same time point and had not returned to baseline at the end of the 28-d intervention. There is considerable research activity looking at effects of vitamin d and it’s metabolites in animal models, cell systems, gene expression studies, epidemiology and clinical therapeutics. Alfred fabian hess stated: Light equals vitamin d. Growing evidence in recent years suggests that vitamin d has an important association with blood pressure.
When given equal molar quantities (Approximately 4,000 iu) of vitamin d 2 or d 3 for 14 days, the subjects who consumed vitamin d 3 demonstrated a 1,7-times greater efficacy in raising plasma 25-ohd levels. All of these conditions have been linked with vitamin d levels in at least one study. The aforementioned meta-analysis of observational studies Indicates that with the 4,7 ng/ml increase in 25-hydroxyvitamin d level obtained in the whi trial, a 7% decrease in the risk of colorectal cancer could have been expected. What is less clear are the exact doses necessary to maintain vitamin d health or repair inadequacies, and what the evidence is upon which these official and anecdotal recommendations are made. The majority of the data supports association, not causation, of low vitamin d levels. Active 1,25(Oh)2d can be dangerous and is not to be used for general repletion of vitamin d deficiency. Holick mf: Sunlight and vitamin d for bone health and prevention of autoimmune disease, cancers, and cardiovascular disease. Severe vitamin d deficiency in children causes rickets, a softening and weakening of bones, which is a rare disease in the developed world.
Depression – clinical trials of vitamin d supplementation for depressive symptoms have generally been of low quality and show no overall effect, although subgroup analysis showed supplementation for participants with clinically significant depressive symptoms or depressive disorder had a moderate effect. Results of our meta-analysis are compatible with the hypothesis that concomitant calcium supplementation can reduce the compliance to vitamin d supplementation.