Product name: Life Extension, Low Dose Vitamin K2 (MK-7), 45 mcg, 90 Softgels
Quantity: 90 Count, 0.05 kg, 2.8 x 2.8 x 8.4 cm
Categories: Life Extension, Supplements, Vitamins, Vitamin K, Non Gmo
Promotes Arterial Health and Healthy Bones, Dietary Supplement, Non-GMO, An abundance of human clinical data reveals that vitamin K plays a critical role in maintaining healthy bone density by facilitating the transport of calcium from the bloodstream into the bone. Vitamin K is also required by calcium-regulating proteins in the arteries. Matrix Gla-protein (MGP) is a vitamin K-dependent protein, and it must be carboxylated to function properly. Poor vitamin K status leads to inactive uncarboxylated MGP (ucMGP), which accumulates at sites of arterial calcification. Since MGP is a potent local inhibitor of arterial calcification, MGP is important in relation to the health of the entire cardiovascular system. Without adequate vitamin K, calcium in the blood can bind to the arterial wall resulting in calcification. As people age, even a subclinical vitamin K deficiency can pose risks to the vascular system. Poor vitamin K status also results in increased circulating levels of undercarboxylated osteocalcin that is shown to be associated with increased bone loss in postmenopausal women.
You may have thinner blood, but you may also increase arterial calcification with the medically-induced vitamin k deficiency. Overt vitamin k deficiency results in impaired blood clotting, usually demonstrated by laboratory tests that measure clotting time. Yet, observational studies are not designed to making causal inferences, and only randomized controlled trials can evaluate whether phylloquinone may have beneficial effects on bone health (See vitamin k supplementation studies and osteoporosis). Conversion of dietary phylloquinone to tissue menaquinone-4 in rats is not dependent on gut bacteria. The use of vitamin d and vitamin k2 together as an approach to osteoporosis treatment may significantly reduce morbidity and mortality. Gla-rich protein (Grp), a new vitamin k-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates. The triage theory implies that during evolution living organisms have developed systems to preferentially support the transporting of vitamins and trace elements to the tissues important for primary deficiency disease prevention. In some cases, fortified foods and dietary supplements may be useful in providing one or more nutrients that otherwise may be consumed in less-than-recommended amounts. Although the full biological function of mgp is unclear, a hypothesis based on animal data suggests that inadequate vitamin k status leads to undercarboxylated mgp, which could increase vascular calcification and the risk of coronary heart disease.
Life Extension, Low Dose Vitamin K2 (MK-7), 45 mcg, 90 Softgels: Vitamin K, Vitamins, Supplements
2 13 Despite the fact that a high percentage of undercarboxylated osteocalcin indicates poor vitamin k status, this value can also vary based on recent vitamin k intake and supplementation 2 14 and may not indicate chronic vitamin k status. Because suboptimal vitamin k nutritional status may limit carboxylation and result in biologically inactive ucmgp, it has been speculated that vitamin k supplementation may protect against vascular calcification. Vitamin k can interact with some drugs, especially blood thinners, so it is important for people taking prescription medications to speak to their doctor before using a dietary supplement. Oral vitamin k lowers the international normalized ratio more rapidly than subcutaneous vitamin k in the treatment of warfarin-associated coagulopathy. More evidence on the combined role of vitamin k antagonist use and vitamin d on bone and cardiovascular health is urgently needed. Conversion of dietary phylloquinone to tissue menaquinone-4 in rats is not dependent on gut bacteria. This study shows the differential effects of vitamin k and vitamin d supplementation on calcium balance in young rats fed with a normal or low calcium diet. A vitamin d3 and k2 combination supplement is especially beneficial to older women and helps prevent osteoporosis. But you may not know that it’s name actually refers to a group of several vitamins that provide health benefits far beyond helping your blood clot. The discovery of vitamin k-dependent proteins in bone has led to research on the role of vitamin k in maintaining bone health.
Some fruits, such as avocados, kiwifruit and grapes, also contain vitamin k. It may also help with regulating insulin sensitivity and reducing skin reddening, but more research is needed to determine if vitamin k has an active role to play in these areas. Seven of these trials, which took fractures into consideration, found that vitamin k2 reduced spinal fractures by 60%, hip fractures by 77% and all non-spinal fractures by 81%. Pregnant women were compared in three arms: Any vk dosage versus none; Vk versus placebo or none; Micronutrients containing vk versus micronutrients without vk. Moreover, high-dose vitamin k 1 or vitamin k 2 restored arterial distensibility back to that seen in control rats. A person can also purchase vitamin k as a standalone supplement or in combination with specific nutrients, such as vitamin d, calcium, or magnesium. However, because of differences in absorption and transport to tissues throughout the body, vitamin k1 and k2 could have profoundly different effects on your health. The extra carboxyl group in gla made clear that vitamin k plays a role in a carboxylation reaction during which glu is converted into gla.
They have extensive research behind their product and have combined the mk7 from fermented chickpea with essential cofactors that increase uptake of vitamin k2, it has 160 mcg of mk7 per capsule. More clinical data about the potential interplay between vitamin d and vitamin k metabolism is urgently needed before broader treatment recommendations can be given. It is estimated that around 30-80% of the population worldwide suffers from some type of deficiency of this vitamin, caused mainly by reduced exposure to sunlight, the popularity of sunscreen and the rise in the number of people living a sedentary, indoor lifestyle. Animals that eat this feed, like chickens and cows, end up with mk-4 form of vitamin k2 in the food they produce, like eggs, butter, or meat. With limited vitamin k storage capacity, the body recycles vitamin k in the vitamin k oxidation- reduction cycle in order to reuse it multiple times. There is some intriguing evidence that menaquinone-4 may possess other antiosteoporotic properties that are specifically associated with the geranylgeranyl side chain of this k 2 vitamin. Although novel direct oral anticoagulants are available, these are often considered unsuitable for patients with a glomerular filtration rate below 30 ml/min/1,73m 2, also, in healthy subjects it was shown that the majority has subclinical vitamin k deficiency as deduced from the presence of increased concentrations of uncarboxylated vkdp in the circulation (22, 180, 224).
Further studies are needed to ascertain the effect of k2 supplements in patients with diabetes and inflammatory bowel diseases. However, these products must be used for at least 6 months to resolve an acute case of hypovitaminosis. Menaquionones, vitamin k2, form a sub-family in which the length of the side chain may change from 1 to 13 isoprene residues. Although allergic reaction is possible, there is no known toxicity associated with high doses (Dietary or supplemental) of the phylloquinone (Vitamin k 1) or menaquinone (Vitamin k 2) forms of vitamin k. People with liver or kidney problems have a sensitive metabolism and should consult a health professional before starting to take these vitamins. Overviews of the other fat-soluble vitamins, minerals, and water-soluble vitamins are available elsewhere. To maintain good health, make sure to get adequate amounts of vitamins k1 and k2 through your diet.
Life Extension Vitamin K
How much vitamin k2 should i take in a day? Abnormal clotting is not related to excessive vitamin k intake, and there is no known toxicity associated with vitamin k 1 or vitamin k 2 (See toxicity). Vitamin k supplementation in post-menopausal patients appeared beneficial in combination with calcium and vitamin d3 for bone health and vasculature. Furthermore, we can assure you that everything that is on our label is consistent with what goes into our vitamins and supplements. In this review we provide the latest insights of the calcium paradox and the potential of using vitamin k to support both bone and vascular health. Consequently, severe liver disease results in lower blood levels of vitamin k-dependent clotting factors and an increased risk for uncontrolled bleeding (Hemorrhage). In it’s report, the fnb stated that no adverse effects associated with vitamin k consumption from food or supplements have been reported in humans or animals.
When a protein expresses glutamate, it is targetted by vitamin k, which causes it to collect more calcium ions. When vk absorption is impaired, for instance in cystic fibrosis, celiac disease, or other condition, taking vk supplements is required, ideally in multivitamin form, which is considered to be more beneficial than vk alone 4, pregnant women consuming anticonvulsant drugs are advised to have vk either 2 or 4 weeks before delivery 4, 17 and should be carefully assessed 20, from 36 weeks of gestation, women taking anticonvulsants 21 were given parenteral or oral vk dosages e. Moreover, mk-7 improved arterial stiffness and elastic properties of the carotid artery in a healthy postmenopausal woman And improved vitamin k status in dialysis patients by decreasing inactive levels of mgp by daily supplementation. Most clinical trials studied vitamin d and k supplementation with bone health in postmenopausal women. Modern science designates the two types of vitamin k as k1 and k2: Vitamin k1 is phylloquinone, and is found in leafy green plant foods (And many green drinks); vitamin k2 is menaquinone, occurring in fermented foods and animal products. I wanted to use vitamin k2, but i am on coumadin/warfarin for heart problems caused by a heart attack i had 16 years ago. Nevertheless, the biochemistry of vitamin k suggests that unnecessarily high doses could rob the body of antioxidants or interfere with blood sugar regulation, insulin sensitivity, and hormonal health.
Adults need approximately 0,001mg a day of vitamin k for each kilogram of their body weight, according to the nhs. Vitamins d and k are both fat-soluble vitamins and play a central role in calcium metabolism. You are right about the ca-supplements, which mostly cause overdosing. The advantage of lowering phosphate concentrations if thus offset by aggravation vitamin k deficiency. The most common sources of vitamin k in the u. The reason why fclo is recommended is that it has natural pre-formed vitamins a and d3, it is the only reason why it is better than regular fish oil. The most common number of these residues is four, since animal enzymes normally produce menaquinone-4 from plant phylloquinone. These findings support the in vitro notion and hypothesis that phosphate binders induce a vitamin k-deficiency.
The health claims for vitamin k have had support from the european food safety authority in recent years, with the body stating that vitamin k contributes to maintenance of normal bone, and vitamin k contributes to normal blood coagulation. The vitamin k family appears to be really busy. Our team feels that these are the best options available right now if you are looking for a vitamin k2 supplement. Notes: Consult with your health care practitioner before taking vitamin k if you are taking coumadin, warfarin or other anticoagulant medications. Note that taking vitamin k1, k2 and e without the other two fat-soluble vitamins (D3 and a) may cause some issues themselves. Naturally occurring forms of vitamin k include a number of vitamers known as vitamin k 1 and vitamin k 2 (Figure 1). The identification of gla as the result of vitamin k action has made it possible to search for vitamin k-dependent proteins on the basis of their amino acid structure: Each protein in which gamma-carboxyglutamate, generally referred to as gla, is found contains the fingerprint of vitamin k action during it’s biosynthesis. Vitamin k2 permits vitamin d3 to perform well, but at the same time, prevents the adverse side effects associated with vitamin d3 supplements containing heavy doses. 2 Are you ok with using a bio-identical synthetic form of vitamin or does it have to be naturally occurring?
Vitamin d2 can be found in some vegetables, while eating food products derived from animals certain mushrooms increases reserves of vitamin d3 in the body. Both trials reported that in patients who had low levels of vitamin k measured in the blood and also another laboratory marker of vitamin k (Undercarboxylated osteocalcin), these levels returned to the normal range after one month of daily supplementation with 1 mg of vitamin k. The development of new anticoagulants that do not block vitamin k recycling may offer a safer alternative to the use of vitamin k antagonists. I always was active and took a multi vit, and an extra calcium supplement for years, but no k2 or magnesium. Unlike many common vitamins, such as vitamin c, vitamin k2 is fat soluble, not water soluble. Quickly and easy look up evidence on over 400 supplements across over 500 different health goals, outcomes, conditions, and more. These, along with vitamin e complex, are called fat-soluble vitamins. The effect of vitamin k intakes and status on bone health and osteoporosis has been a focus of scientific research.