Product name: Natural Factors, Pycnogenol, 25 mg, 60 Vegetarian Capsules
Quantity: 60 Count, 0.05 kg, 5.6 x 5.6 x 9.9 cm
Categories: Natural Factors, Supplements, Antioxidants, Pine Bark Extract, Pycnogenol, Non Gmo, Vegetarian, Vegan
Dietary Supplement, French Maritime Pine Bark Extract, Healthy Aging, Isura – Non-GMO – Mass-Spec – Documentation – Lab Tested, Suitbale for Vegetarians / Vegans, Pycnogenol French maritime pine bark extract is extracted from the bark of pine trees (Pinus pinaster) grown exclusively in Les Landes de Gascogne forest in southwest France near the famous Bordeaux region. The forest is an unspoiled and natural plantation with no pesticides and no herbicides. May help provide support for healthy joint function and maintenance. May support natural inflammation transition from acute to resolution state. Helps reduce (climacteric) symptoms associated with peri-menopause including hot flushes, restlessness (difficulty falling asleep), and poor mental concentration and focus. Helps support cognitive health in an aging population (>60 years of age). Provides antioxidants for the maintenance of good health.
The primary hypothesis was that pine bark extract would lower blood pressure in a population of overweight and obese participants with baseline prehypertension or hypertension. Densiflora bark extract could be a new agent for preventing age-related nuclear cataract. Laboratory evidence suggests that certain specialty dietary supplements have antiinflammatory properties, though evidence in humans remains limited. I have listed the daily dosage recommendations for common applications of pycnogenol, but it is better to consult with your doctor to get more information about the dosage that is right for you taking into account your medical history. Reactive oxygen species (Ros) production, lipid peroxidation, reduction of antioxidant enzymes, crystalline proteolysis, and apoptosis are considered factors that contribute to pathogenesis of age-related nuclear cataract. The strength of this study is that it is the first meta-analysis to assess the potential role of arginine supplements in ed compared with placebo or no treatment. It is a natural source of several antioxidants including proanthocyanidins, which are also found in wine, grapes, apples, cocoa, tea, nuts, and some berries.
Natural Factors, Pycnogenol, 25 mg, 60 Vegetarian Capsules: Pycnogenol, Pine Bark Extract, Antioxidants, Supplements
Toyo shinyaku co, ltd provided study tablets (Toyo-fvg pine bark extract and placebo). In another group of 19 american smokers, increased platelet aggregation was more significantly reduced by 200 than either 150 mg or 100 mg pycnogenol supplementation. Significant potential for skin protection against harmful uv radiation is recognized in plant origin substances, which primarily exhibit an antioxidant effect, and additionally possess other photoprotective properties, which makes them interesting for further investigation. The bark, from trees grown along the coast of southwest france, is processed and turned into a tonic that contains powerful antioxidants and anti-inflammatory compounds. Pinaster revealed the highest activities, whereas other parts of the plant did not display any appreciable wound healing, anti-inflammatory, or antioxidant effects. Conclusions this pine bark extract (At a dosage of 200 mg/d) was safe but was not associated with improvement in cardiovascular disease risk factors. The purpose of the present study was to examine whether 14 days of supplementation with maritime pine extract leading up to and following an exercise test would increase performance and reduce biomarkers associated with muscle damage, inflammation, and oxidative stress.
Athletes can also benefit from the increase in no supported by pine bark extract, through enhanced circulation and blood flow. Smoking increased platelet aggregation that was prevented after administration of 500 mg aspirin and 125 mg pycnogenol. Over all, the scientists found that most of the studies on the supplement were too flawed to prove it’s efficacy. In a study of 61 adhd children, pycnogenol reduced hyperactivity, improved attention, and motorics after 1 month. Is available in more than 1,000 dietary supplements, multi-vitamins and health products worldwide. Pycnogenol is one of the most powerful natural antioxidants. Pycnogenol is the trade name for an extract of french maritime pine bark (Pinus pinaster). A clinical trial of 57 adhd children found that daily pycnogenol (1 Mg/kg) for one month may reduce hyperactivity symptoms. Doses of pine bark extract have been studied in clinical trials, most commonly at 150 mg per day in 3 divided doses.
Pycnogenol is an extract of french maritime pine bark (Pinus pinaster) that consists of a concentrate of polyphenols, mainly procyanidins. Pycnogenol is a patented formulation of pine bark extract which is standardized to 65-75% procyanidin compounds by weight. They have discovered pycnogenol is effective due to it’s double function. Foodpharmacy Blog and it’s editors do not ensure that unforeseen side effects will not occur even at the proper dosages, and thereby does not assume liability for any side effects from supplements or practices hosted under the domain of examine. To investigate possible mechanisms involved in pycnogenol’s suppression of peroxide release, confluent monolayers of j774 cells were incubated with pycnogenol for 18 h, washed, resuspended in phosphate buffered saline, and sonicated to obtain a cell lysate. For that reason, you should be careful taking pine bark if you have hypertension or diabetes. Although these supplementations are individually known to benefit rheumatoid arthritis (Ra), there is no evidence suggesting any synergic effect. Roy krebs is the founder and ceo of natural stacks, an open source supplement company with targeted brain health products to help improve mood, memory and focus.
The effects of a bioflavonoid mixture, pycnogenol, were assessed on platelet function in humans. One such antioxidant, pycnogenol, is a standardized plant-based extract obtained from the bark of the french maritime pine and has a long historical use to treat inflammation and improve health. Here we report the scavenging activity of pycnogenol (The polyphenols containing extract of the bark from pinus maritima) against reactive oxygen and nitrogen species, and it’s effects on no metabolism in the murine macrophages cell line raw 264,7, macrophages were activated by the bacterial wall components lipopolysaccharide (Lps) and interferon (Ifn-gamma), which induces the expression of large amounts of the enzyme nitric oxide synthase (Inos). Pine bark was significantly more effective than the placebo in all these aspects. Total rna was extracted and vcam-1 mrna levels were measured by rt-qpcr. Sixteen lipid and aqueous antioxidants (Aox) from natural or synthetic sources, including five flavonoids, were evaluated for their ability to inhibit the oxidative reaction. A study of 47 women with painful menstrual cramps who were given 30 mg pycnogenol twice a day, showed subjects had fewer days of menstrual pain when taking the product.
Natural Factors Pycnogenol
The resulting inhibition of cartilage-destructing proteases and pain-producing cyclo-oxygenases provides the basis for relief from pain, improvement of stiffness, enhanced mobility, and well-being in three clinical studies with the pine bark extract as an adjunct supplement. The results indicate that pycnogenol exhibits an extensive antioxidant effect in all three in vitro systems. Some studies have found that supplements made from the bark can be beneficial. However, it was found that the ultrasonic assistance increased the effect of extraction for recovery of phenolic compounds. Pyc is a plant-based extract derived from the bark of the french maritime pine. Antidiabetic effect of pycnogenol french maritime pine bark extract in patients with diabetes type ii. Shand et al 12 observed a decrease of 7 mm hg in systolic plus diastolic blood pressures combined for 24 participants taking pine bark extract (480 Mg/d) for 12 weeks, while hosseini et al 22 noted a decrease in systolic blood pressure for 11 participants taking pine bark extract (200 Mg/d) for 8 weeks.
To see the full set of research information and references for pycnogenol. The pine tree is native to the western and southwestern mediterranean regions but has rapidly naturalized to other countries, including the united states, england, south africa, and australia. 24 Hence, study findings about this pine bark extract (At 200 mg/d) may not be fully applicable to other pine bark extracts or to antioxidant dietary supplements in general. Pine bark extract is generally well tolerated, with occasional minor gastric discomfort, dizziness, nausea, and headache. A trial of children with adhd found that pycnogenol may improve attention, possibly by increasing the total antioxidant status and reducing dna damage. It was recently shown that pycnogenol (Pyc; a proprietary mixture of water-soluble bioflavonoids extracted from french maritime pine bark) was selectively toxic to established malignant ovarian germ cells. There is growing interest in the biologic activities of plant extracts such as that obtained from the bark of the french maritime pine pinus maritima, pycnogenol. Several laboratory studies have found that some of these bioflavonoids have anti-inflammatory and antioxidant properties.
The group taking pycnogenol had significantly improved pulmonary functions and asthma symptoms. Perimenopausal women who took pycnogenol for eight weeks noticed decreased cholesterol and triglyceride levels. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Our preliminary data indicated that 10% tahitian noni liquid dietary supplement or tahitian noni juice (Tnj), made from morinda citrifolia fruit by morinda inc, in drinking water for one week was able to prevent dmba-dna adduct formation. However, a recent study showed that the korean red pine (P. The pharmacology of the 19th century, with it’s extensive use of the anti-inflammatory willow bark, followed empirically the modern concept that free radicals are produced at sites of inflammation. The extract has been used for anemia, inflammation, and cardiovascular conditions.
Com does not assume liability for any actions undertaken after visiting these pages, and does not assume liability if one misuses supplements. Pine bark extract is a powerful antioxidant packed full of oligomeric proanthocyanidin compounds (Opcs). By becoming an examine plus member, you will have access to all of the latest nutrition research on over 300 supplements across over 500 different health goals, outcomes, conditions, and more. It ranks as one of the top-selling herbal dietary supplements in the united states. If possible, try to get pycnogenol from a local supplier, such as a health food store. This metabolite is no constituent of the extract, but is generated in vivo from the procyanidins Catechin units through multiple step reactions. In a study of 33 people with severe osteoarthritis, pycnogenol (200 Mg/day) reduced inflammatory markers after 3 weeks.
In this study, phytochemical composition, antioxidant, anti-inflammatory, and wound healing activities of maritime pine (Pinus pinaster ait). 1 Subjects with grade 1 or 2 osteoarthritis in one or both knees were evaluated after supplementation with pycnogenol. This information relates to an herbal, vitamin, mineral or other dietary supplement. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect. Pine bark extract, a dietary supplement source of antioxidant oligomeric proanthocyanidin complexes, has multiple putative cardiovascular benefits. There are limited clinical data showing pine bark extract can be used together with standard blood pressure medication. The antioxidant properties of pycnogenol support the maintenance of healthy retinal capillaries and better vision.
One critical point with plant extracts is always the bioavailability of their constituents. Since grape extract (Ge) contains oligomeric proanthocyanidins and numerous polyphenols, dietary ge supplements may exert protective effects against various diseases. The proprietary extract comes from the bark of the french maritime pine tree pinas pinaster, which grows on the coast of southwest france. The fluorangiography showed an improvement of retinal vascularization and a reduced endothelial permeability and leakage in the pycnogenol, but not in the placebo-treated, patients. Maritime pine extract is included in the united states pharmacopeia. In a nutshell, the french maritime pine bark extract comes from the bark of pinus pinaster growing on the coast of bordeaux, france.