Product name: Nutricology, Pycnogenol 100, 30 Vegetarian Capsules
Quantity: 30 Count, 0.02 kg, 7.6 x 4.1 x 4.1 cm
Categories: Nutricology, Supplements, Antioxidants, Pine Bark Extract, Pycnogenol, Hypoallergenic
Innovative Nutrition, Original French Maritime Pine Bark Extract, Hypoallergenic, Dietary Supplement, Pycnogenol 100, Pycnogenol is the original French maritime pine bark extract, providing a unique combination of procyanidins, bioflavonoids, and phenolic acids. More than 400 published studies and review articles demonstrate its safety and efficacy.
In addition to main stream medical treatments, there is increasing popularity in using natural compounds for their intrinsic anti-inflammatory and antioxidant properties. Without any treatment (Placebo) the retinopathy progressively worsened during the trial and the visual acuity significantly decreased; on the contrary, the pycnogenol-treated patients showed no deterioration of retinal function and a significant recovery of visual acuity was also obtained. In conclusion, our results demonstrate the anti-inflammatory and antioxidant potential of hiper containing the natural products, pbe, honey, aloe vera, and papain. The adverse events and adverse effects questionnaire asked about symptoms commonly reported in past studies of pine bark extract, hospital and emergency department visits, new diagnoses, and changes in existing diagnoses. Currently pycnogenol is available in a number of forms, as a dietary supplement, a powder or cream that is often used in cosmetics, a multi-vitamin, and other health products such as health drinks. Doses of pine bark extract have been studied in clinical trials, most commonly at 150 mg per day in 3 divided doses. You are using anticoagulant and/or antiplatelet drugs: Pine bark extract can inhibit platelet aggregation and may increase risk of bleeding when used with these drugs.
Nutricology, Pycnogenol 100, 30 Vegetarian Capsules: Pycnogenol, Pine Bark Extract, Antioxidants, Supplements
Although the type of rampant inflammation during a flare far-exceeds the ability of pycnogenol, it has shown some efficacy for patients in remission phases of their disease, where symptoms tend to be driven by lower-level, chronic inflammation. The results obtained suggest that pycnogenol could be useful for second line therapy to reduce the inflammatory feature of sle. No positive outcomes indicating that pycnogenol reduces intra-abdominal adhesions were obtained. Essential oil composition and the amount of extracts (Lipophilic and hydrophilic) of maritime pine wood and fresh cone samples had been tested. I have listed the daily dosage recommendations for common applications of pycnogenol, but it is better to consult with your doctor to get more information about the dosage that is right for you taking into account your medical history. More research is needed to determine which individuals with hypertension may benefit from supplementation. The extract has been used for anemia, inflammation, and cardiovascular conditions. Pine bark extract can be taken either with or between meals.
Twenty apparently healthy young male participants ingested either 800 mg pine bark extract or placebo for 14 days prior to the first exercise trial and for 2 days postexercise. We also know exactly what is in pycnogenol, that it is 100 percent natural and free from pesticides and herbicides. The effects of a bioflavonoid mixture, pycnogenol, were assessed on platelet function in humans. We hypothesized that this sum would decrease by at least 7 mm hg in the pine bark extract group relative to the placebo group after 12 weeks. While no specific incidents have been reported, as an immunostimulant, pycnogenol may increase symptoms of immune system disorders such as multiple sclerosis, lupus, and rheumatoid arthritis. Some other species such as pilea cadieri, although rich in prodelphinidin, are not suitable as sources because of the inextractability of the tannin. Thus, a meta-analysis was conducted to examine the effect of pycnogenol supplementation on bp. In vitro and animal studies using the standardized extract have indicated a multimodal action of pycnogenol, and several human studies have shown improvements in cognitive function after chronic administration. Roy krebs is the founder and ceo of natural stacks, an open source supplement company with targeted brain health products to help improve mood, memory and focus.
Pycnogenol is an extract of french maritime pine bark (Pinus pinaster) that consists of a concentrate of polyphenols, mainly procyanidins. 27 Issue of the archives of internal medicine, is the largest randomized, placebo-controlled clinical trial to date examining the effects of pine-bark extract on blood pressure and other heart disease risks. The water extract of it’s bark is used treat several diseases, including some types of arthritis. Trusted suppliers of pycnogenol are those that have been gmp-certified. Research has shown that taking pycnogenol daily for 2 months can prevent or reduce the symptoms of retinal disease caused by diseases such as diabetes and atherosclerosis. This may account for variations in physiologic effects among different pine bark extract preparations and among antioxidants in general. We conclude that pycnogenol has the potential to counteract all important cardiovascular risk factors simultaneously. Probiotic complex, zinc, and coenzyme q10 (Coq10) are recognized dietary supplements with an anti-inflammatory role. One such antioxidant, pycnogenol, is a standardized plant-based extract obtained from the bark of the french maritime pine and has a long historical use to treat inflammation and improve health. In addition, pycnogenol can help maintain your skin elasticity and hydration and slow the aging process. Pine bark has a great content of bioactive molecules including polymeric flavanols, tannic acid, flavonoids and other phenolic acids such as caffeic or protocatechuic acid.
The comparison of 42 two-dimensional protein patterns from megagametophytes of maritime pine from seven geographical origins enabled the analysis of the genetic variability of abundant proteins. Foodpharmacy Blog and it’s editors do not ensure that unforeseen side effects will not occur even at the proper dosages, and thereby does not assume liability for any side effects from supplements or practices hosted under the domain of examine. Studies have also shown that pycnogenol can have a positive effect on arthritis and osteoarthritis. It used a rigorous randomized controlled trial method, while most other studies of pine bark extract were open label and lacked clear data collection techniques. Approximately 60% of patients treated with pycnogenol(R) experienced a complete disappearance of edema (The most rapidly disappearing symptom) and pain at the end of the treatment, while almost all the patients reported a reduction in leg heaviness which disappeared in approximately 33% of patients. Pycnogenol is a mixture of flavonoid compounds extracted from the bark of pine trees. Pine bark extract is available through other companies not using pycnogenol, except that they may use different types of pine bark and have dissimilar formulations.
An improvement in cognitive function has been observed in controlled animal experiments and these findings support anecdotal reports of improvement in adhd patients taking pyc supplements. In addition to it’s skin-healing properties, pycnogenol also shows promise for helping children manage adhd symptoms. Here we report the scavenging activity of pycnogenol (The polyphenols containing extract of the bark from pinus maritima) against reactive oxygen and nitrogen species, and it’s effects on no metabolism in the murine macrophages cell line raw 264,7, macrophages were activated by the bacterial wall components lipopolysaccharide (Lps) and interferon (Ifn-gamma), which induces the expression of large amounts of the enzyme nitric oxide synthase (Inos). Shand et al 12 observed a decrease of 7 mm hg in systolic plus diastolic blood pressures combined for 24 participants taking pine bark extract (480 Mg/d) for 12 weeks, while hosseini et al 22 noted a decrease in systolic blood pressure for 11 participants taking pine bark extract (200 Mg/d) for 8 weeks. The aim of this study is to investigate anticancer effect of pycnogenol in mc-3 human mucoepidermoid carcinoma (Mec) cell line. The group taking pycnogenol had significantly improved pulmonary functions and asthma symptoms. Is available in more than 1,000 dietary supplements, multi-vitamins and health products worldwide.
In this study, we compared the response of human breast cancer cells (Mcf-7) and normal human mammary cells (Mcf-10) to apoptosis in the presence of pycnogenol. A new study from the stanford university school of medicine shows that pine-bark extract had no effect in lowering blood pressure or reducing other risk factors for heart disease. Inhibition mechanisms of bioflavonoids extracted from the bark of pinus maritima on the expression of proinflammatory cytokines. The resulting inhibition of cartilage-destructing proteases and pain-producing cyclo-oxygenases provides the basis for relief from pain, improvement of stiffness, enhanced mobility, and well-being in three clinical studies with the pine bark extract as an adjunct supplement. The pharmacology of the 19th century, with it’s extensive use of the anti-inflammatory willow bark, followed empirically the modern concept that free radicals are produced at sites of inflammation. The opcs in pine bark extract are recommended for various eye conditions that are caused by blood vessel damage, such as diabetic retinopathy and macular degeneration. Some people taking pycnogenol may experience bad breath, upset stomach, dizziness, sores in the mouth, or headaches. Devaraj s, vega-lopez s, kaul n, schonlau f, rohdewald p, jialal i : Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile.
Pine bark extract is used to reduce the risk and severity of heart disease, strokes, high cholesterol, and circulation problems. To summarize, we found that caffeic acid, taxifolin, ferulic acid, and m1 all bind to human erythrocytes, but only the pycnogenol metabolite m1 revealed accumulation within the cells. If you have trouble finding a supplier you trust, many of the active ingredients of pycnogenol can also be extracted from other sources, including peanut skin, grape seed, and witch hazel bark. Evidence supports the use of dietary supplements such as fish oil for treating and preventing cvd, but rigorous evidence of efficacy and safety is lacking for most supplements. Pine bark extract, a dietary supplement source of antioxidant oligomeric proanthocyanidin complexes, has multiple putative cardiovascular benefits. Reducing exposure to free radicals and increasing intake of antioxidant nutrients has the potential to reduce the risk of free radicalrelated health problems. According to the makers of pycnogenol, the extract has four basic properties. The results demonstrated a beneficial effect of pycnogenol on the progression of retinopathy. Many pine bark extracts on the market are not standardized and the concentration of active components and bioactivities are hard to determine.
It is important to understand whether any pharmacokinetic interactions are among the major constituents of these supplements so as to provide information when considering the combination use of these supplements. Following our a priori primary analysis plan, the effect of pine bark extract on the primary outcome, 12-week blood pressure change, was examined using a regression model with 12-week blood pressure change as the dependent variable and with baseline blood pressure as a covariate. French maritime pine bark extract inhibits viral replication and prevents development of viral myocarditis. 3 This is why supplements derived from some of these plants have been shown to have similar effects as pycnogenol. Of japan, which provided the pine-bark extract along with the placebo tablets. For 12 weeks, participants took either the pine bark extract or a placebo. The fluorangiography showed an improvement of retinal vascularization and a reduced endothelial permeability and leakage in the pycnogenol, but not in the placebo-treated, patients. To assess the potential role of arginine supplements on ed as alternatives to phosphodiesterase inhibitors. Pine bark extract can make a great addition to your nutritional arsenal for it’s potent antioxidant support, as well as it’s added support for blood flow, blood sugar, inflammation, immunity, brain function and skin support.
Several studies 8, 12, 22 reported that pine bark extract decreases blood pressure. 1 A majority of the studies reviewed in this article focus on it’s antioxidant, anti-inflammatory, and vasodilation properties. When catechin and palm oil vitamin e, catechin and coenzyme q Or coenzyme q And pycnogenol were combined, the individual effect was enhanced. Pycnogenol is similar to grape seed extract and cocoa polyphenols as those are the three most common sources of procyanidins. In light of this, the antioxidant mechanisms of pyc are discussed below.